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Prophylactic adenine arabinoside following marrow transplantation.

Abstract：

:Interstitial pneumonia is a major cause of morbidity and mortality following allogeneic marrow transplantation for hematologic malignancy. In this prospective randomized study, 22 of 40 patients received prophylactic adenine arabinoside (Ara-A) at a dose of 5 mg/kg/day administered intravenously on an intermittent schedule. Thirteen episodes of interstitial pneumonia occurred among treated patients, including three cases associated with cytomegalovirus (CMV) in the lung. Ten episodes of interstitial pneumonia were seen in the untreated group, with CMV cultured from five. Surveillance viral cultures were positive from 18 different sites in 12 treated patients compared to 10 sites from 7 patients in the untreated group. No significant toxicity from Ara-A was encountered, and no difference in overall survival between the two groups was detected. Ara-A did not reduce the frequency of interstitial pneumonia or viral isolation from routine cultures.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Kraemer KG,Neiman PE,Reeves WC,Thomas ED

subject

Has Abstract

pub_date

1978-03-01 00:00:00

pages

237-40

issue

1

eissn

0041-1345

issn

1873-2623

journal_volume

10

pub_type

临床试验,杂志文章,随机对照试验

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