Biopharmaceutical aspects of FK-506.

Abstract:

:FK is a potent immunosuppressive agent. FK can be analyzed in biologic fluids by EIA. The oral absorption of FK is rapid but variable in dogs. After intramuscular administration, FK is slowly and continuously absorbed. FK is primarily eliminated by metabolism. Less than 1% of the administered dose is excreted in the bile or the urine. After chronic intramuscular administration FK inhibits drug metabolism. Monitoring of FK levels in plasma is essential for the proper interpretation of efficacy and toxicity studies.

journal_name

Transplant Proc

authors

Venkataramanan R,Warty VS,Zemaitis MA,Sanghvi AT,Burckart GJ,Seltman H,Todo S,Makowka L,Starzl TE

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

30-5

issue

5 Suppl 6

eissn

0041-1345

issn

1873-2623

journal_volume

19

pub_type

杂志文章
  • Reactivations of cytomegalovirus, human herpes virus 6, and Epstein-Barr virus differ with respect to risk factors and clinical outcome after hematopoietic stem cell transplantation.

    abstract::One hundred two recipients of hematopoietic stem cell transplants (HSCTs) 45, from siblings and 57 from matched unrelated donors, were followed for cytomegalovirus (CMV), human herpes virus (HHV) 6, and Epstein-Barr Virus (EBV) reactivation by quantitative polymerase chain reaction in the context of immunologic recons...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.07.027

    authors: Jaskula E,Dlubek D,Sedzimirska M,Duda D,Tarnowska A,Lange A

    更新日期:2010-10-01 00:00:00

  • Association of hyperglycemia on allograft function in the early period after renal transplantation.

    abstract::Hyperglycemia is common following renal transplantation. This study was conducted to evaluate the relationship of perioperative serum glucose levels and acute rejection in 100 nondiabetic patients who underwent renal transplantation. Blood glucose was measured immediately following surgery and every 6 hours during the...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.03.030

    authors: Ganji MR,Charkhchian M,Hakemi M,Nederi GH,Solymanian T,Saddadi F,Amini M,Najafi I

    更新日期:2007-05-01 00:00:00

  • One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.

    abstract::An account is given of the 6- to 12-month survival, and causes of failure in 110 consecutive patients who underwent primary liver transplantation under treatment from the outset with FK 506 and steroids. The patient survival is 92.7%, and the first graft survival is 87.3%. At a very high frequency, the patients achiev...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:

    authors: Todo S,Fung JJ,Tzakis A,Demetris AJ,Jain A,Alessiani M,Takaya S,Day R,Gordon R,Starzl TE

    更新日期:1991-02-01 00:00:00

  • Mitral valve dysfunction and repair following orthotopic heart transplantation: a case report.

    abstract::Mitral valve dysfunction after orthotopic heart transplantation may cause symptoms refractory to medical therapy. In this report, we present a patient who underwent mitral annuloplasty for severe symptomatic mitral valve insufficiency 9 years after heart transplantation, and we critically appraise the literature avail...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.10.010

    authors: Wigfield CH,Lewis A,Parry G,Dark JH

    更新日期:2008-06-01 00:00:00

  • The evolution of therapeutic strategies for biliary tract complications after liver transplantation over a period of 20 years.

    abstract::Despite the improved overall outcomes of liver transplantation as a result of advances in surgical techniques and improved immunosuppressive control, biliary complications (BCs) continue to be the most common cause of morbidity in liver transplant recipients. The objectives of this study were to analyze the incidence,...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.07.073

    authors: González MR,Cascales PA,Abellán I,Pons JA,Miras M,Capel A,Sánchez Bueno F,Robles R,Febrero B,Ríos A,Ramírez P,Parrilla P

    更新日期:2012-09-01 00:00:00

  • Time-related changes in the incidence, severity, and clinical outcome of hepatic veno-occlusive disease in hematopoietic stem cell transplantation patients during the past 10 years.

    abstract::Veno-occlusive disease (VOD) of the liver occurs in 10% to 50% of patients after hematopoietic stem cell transplantation (HSCT), ranging from a mild reversible disease to a fulminant course with a mortality rate close to 100%. We retrospectively evaluated the clinical signs, diagnosis, prognosis, therapy, and outcome ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.03.025

    authors: Kalayoglu-Besisik S,Yenerel MN,Caliskan Y,Ozturk S,Besisik F,Sargin D

    更新日期:2005-06-01 00:00:00

  • Reproducible model for kidney autotransplantation in pigs.

    abstract:OBJECTIVE:Several porcine models have been employed to study mechanisms of warm ischemia, cold ischemia, and ischemia reperfusion injury, but the technical/surgical aspects of these models and their possible pitfalls have not been fully described in detail. The goal of the present study was to develop and optimize a po...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.09.024

    authors: Jochmans I,Lerut E,Heedfeld V,Wylin T,Pirenne J,Monbaliu D

    更新日期:2009-10-01 00:00:00

  • Changes in renal transplantation: comparison between two different series.

    abstract:BACKGROUND:New immunosuppressives have improved the results of renal transplants. However, the features of donors and recipients have changed, producing an increased age in both cases and more donors dying from strokes. We analyzed the impact of donor and recipient profile on survival of graft in recipients treated wit...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2005.09.099

    authors: Marqués GG,Goenaga PE,Royo FJ,Fernández NG,Escolá JM,Unanua AP

    更新日期:2005-11-01 00:00:00

  • Knowledge, attitudes, and behaviors of officials of religion about organ donation in Kahramanmaras, an eastern Mediterranean city of Turkey.

    abstract:OBJECTIVE:To establish the knowledge, attitudes, and behaviors of the officials of religion, a group with potentially powerful influence on the society, in particular regarding organ donation. METHODS:This study, performed in Kahramanmaras Province, Turkey, included 416 of 641 officials of religion (64.9%): 295 of 492...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.08.035

    authors: Ozer A,Ekerbicer HC,Celik M,Nacar M

    更新日期:2010-11-01 00:00:00

  • Is a High Body Mass Index Still a Risk Factor for Complications of Donor Nephrectomy?

    abstract:BACKGROUND AND AIM:The incidence of obesity is increasing all around the world and Turkey is no exception. In Turkey, 80.1% of all kidney transplants performed in 2013 were living donor kidney transplants. In this study we compare the early postoperative complications of living kidney donors with a body mass index (BMI...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2015.04.061

    authors: Uguz A,Unsal MG,Unalp OV,Sezer T,Celtik A,Sozbilen M,Toz H,Hoscoskun C

    更新日期:2015-06-01 00:00:00

  • Long-term graft outcome analyzed from a national registry point of view.

    abstract::It has been 10 years since the "Taiwan Organ Registry and Sharing Center" (TORSC) was founded by the Department of Health in June 2002. The mission of TORSC is to build a fair organ sharing and registration network and also a national database collection and analysis mechanism. TORSC is also dedicated to improving the...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.11.102

    authors: Chiang YJ,Hsu KH

    更新日期:2014-01-01 00:00:00

  • Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations.

    abstract:AIMS:We report a single-center experience of islet allogeneic transplantation in islet after kidney (IAK) and simultaneous islet-kidney (SIK) type 1 diabetic recipients using a steroid-free immunosuppressive regimen. METHODS:Eight patients received 12 islet infusions in 5 IAK and 3 SIK procedures. Median age was 51 ye...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.04.027

    authors: Berney T,Bucher P,Mathe Z,Andres A,Bosco D,Mage R,Toso C,Oberholzer J,Becker C,Philippe J,Bühler L,Morel P

    更新日期:2004-05-01 00:00:00

  • Selection Criteria for Kidney Laterality in Retroperitoneoscopic Living Donor Nephrectomy and the Usefulness of Pretransplant Intervention.

    abstract:OBJECTIVES:To evaluate the selection criteria for kidney laterality and the usefulness of pretransplant intervention in living donor nephrectomy. METHODS:We compared conventional and revised criteria. The conventional criteria were that left kidneys were chosen in preference and provided the kidney with the fewest str...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2017.03.022

    authors: Nanmoku K,Kurosawa A,Kubo T,Shinzato T,Shimizu T,Kimura T,Yagisawa T

    更新日期:2017-06-01 00:00:00

  • Polyomavirus BK replication in adult polycystic kidney disease post-renal transplant patients and possible role of cellular permissivity.

    abstract::Cell division and differentiation but not proliferation seem to be necessary for BK virus (BKV) replication and reactivation of persistent infection. Only terminal differentiating cells are permissive to BKV replication. Renal tubular epithelial cells in human adult polycystic kidney disease (ADPKD) are characterized ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.02.046

    authors: Mitterhofer AP,Tinti F,Pietropaolo V,Barile M,Chiarini F,Meçule A,Ferretti G,Poli L,Berloco PB,Taliani G

    更新日期:2011-05-01 00:00:00

  • Prognostic value of model for end-stage liver disease scores in patients with fulminant hepatic failure.

    abstract:BACKGROUND:This study was undertaken to investigate risk factors of mortality in patients with fulminant hepatic failure (FHF). METHODS:Fifty-three patients with FHF treated from January 2006 to April 2011 were allocated to a spontaneous survival group (group 1), a death without liver transplantation (LT) group (group...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.08.036

    authors: Lee HS,Choi GH,Joo DJ,Kim MS,Kim SI,Han KH,Ahn SH,Kim DY,Park JY,Choi JS

    更新日期:2013-10-01 00:00:00

  • Pancreata from pediatric donors restore insulin independence in adult insulin-dependent diabetes mellitus recipients.

    abstract:CONTEXT:The use of pediatric donors can increase the number of donors available for pancreas transplantation. AIM:The aim of this study was to verify if pancreas transplantation from pediatric donors is as effective as transplantation from adult donors to restore metabolic control in type 1 diabetic patients. MATERIA...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.05.120

    authors: Socci C,Orsenigo E,Santagostino I,Caumo A,Caldara R,Parolini D,Aldrighetti L,Castoldi R,Frasson M,Carvello M,Ghirardelli L,Secchi A,Di Carlo V,Staudacher C

    更新日期:2010-07-01 00:00:00

  • Nucleosome serum levels in acute hepatic failure and MARS treatment.

    abstract::Serum nucleosomes have been suggested to be markers for cell death and apoptosis. Increased hepatocyte apoptosis can be demonstrated in acute liver failure (ALF) as well as acute-on-chronic liver failure (ACLF). We investigated the relevance of nucleosomes in the setting of acute hepatic failure. Further, we studied t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.08.073

    authors: Roth GA,Lubsczyk BA,Pilz J,Faybik P,Hetz H,Krenn CG

    更新日期:2009-12-01 00:00:00

  • Assessment of the perceived quality of life of successful kidney transplant recipients and their donors pre- and post-transplantation.

    abstract:BACKGROUND:With advanced medical technology, quality of life (QOL) has assumed immense importance. In India, there has been scant research on the QOL of patients with stage 5 chronic kidney disease and their respective donors who make transplantation possible. METHODS:We assessed and compared the QOL of successful kid...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.01.037

    authors: Joshi SA,Almeida N,Almeida A

    更新日期:2013-05-01 00:00:00

  • MeltDose Technology vs Once-Daily Prolonged Release Tacrolimus in De Novo Liver Transplant Recipients.

    abstract:BACKGROUND:An extended-release formulation of tacrolimus designed for once-daily administration (LCP-TAC) is a new prolonged-release tacrolimus (TAC-PR) formulation using a drug delivery technology designed to enhance the bioavailability of drugs compared with TAC-PR. The aim of this study was to retrospectively compar...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.03.084

    authors: Baccarani U,Velkoski J,Pravisani R,Adani GL,Lorenzin D,Cherchi V,Falzone B,Baraldo M,Risaliti A

    更新日期:2019-11-01 00:00:00

  • Large benign hepatocellular nodules in cirrhosis due to chronic venous outflow obstruction: diagnostic confusion with hepatocellular carcinoma.

    abstract::Budd-Chiari syndrome (BCS) in patients progressing to cirrhosis is an indication for liver transplantation. At this stage of disease, it is common to find large benign hepatocellular nodules (LBHNs) of undetermined cause that may be confused with hepatocellular carcinoma (HCC). Patients with indications for liver tran...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.09.070

    authors: Oliveira EC,Duarte AG,Boin IF,Almeida JR,Escanhoela CA

    更新日期:2010-12-01 00:00:00

  • Effects of heme oxygenase-1 transgenic islets on transplantation.

    abstract::Heme oxygenase-1 (HO-1) has been described as a protein capable of cytoprotection via radical scavenging and apoptosis prevention. The aim of this study was to analyze whether HO-1 overexpression in freshly isolated murine transgenic islets resulted in cell protection and improved in vivo functional performance after ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.09.022

    authors: Tu CF,Kuo CH,Juang JH

    更新日期:2005-10-01 00:00:00

  • Shipping impact on liver graft: results of liver transplantation program in Andalusia.

    abstract::Liver transplantation for the treatment of patients with advanced liver disease is organized according to a waiting list taking into account different criteria. The agreed distribution model in Andalusia assumes that sometimes an organ is extracted in a different province to that where the implantation is to be perfor...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.10.032

    authors: Oliver CO,Marente VC,Bellido CB,Martínez JM,Gómez LM,Artacho GS,Canedo JS,Pulido LB,Ruiz FJ,Bravo MA

    更新日期:2013-01-01 00:00:00

  • Impact of mycophenolate mofetil dose posttransplantation on 12-month renal function: analysis of the MOST database.

    abstract:INTRODUCTION:Mycophenolate mofetil (MMF) has greatly reduced the risk of acute rejection episodes (ARE) after renal transplantation, but dose reductions/withdrawals could jeopardize long-term results. METHODS:The MOST database of "de novo" patients treated with MMF at month 1 and functioning grafts at month 12 were di...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2005.06.053

    authors: Salvadori M,Bock A,Chapman J,Dussol B,Fritsche L,Kliem V,Lebranchu Y,Oppenheimer F,Pohanka E,Tufveson G,Rosati A,Puig X,Corbetta G,MOST International Study Group.

    更新日期:2005-07-01 00:00:00

  • Critical progressive small-graft injury caused by intrasinusoidal pressure elevation following living donor liver transplantation.

    abstract::In adult-to-adult living liver transplantation, small-for-size graft syndrome sometimes occurs. The relationship between the hemodynamic changes and histologic findings has not been studied in patients with failure of small-for-size grafts. We analyzed the relationship between the postoperative hemodynamic changes and...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2004.09.036

    authors: Sugimoto H,Kaneko T,Hirota M,Nagasaka T,Kobayashi T,Inoue S,Takeda S,Kiuchi T,Nakao A

    更新日期:2004-11-01 00:00:00

  • The risk of polyomavirus-associated graft nephropathy is increased by a combined suppression of CD8 and CD4 cell-dependent immune effects.

    abstract::Polyomavirus-associated graft nephropathy (PAN) has emerged as a significant risk factor for kidney graft loss. We analyzed intracellular cytokine responses for possible protective versus permissive immunologic effects on BK-virus replication. One hundred five renal transplant patients included in a prospective single...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.transproceed.2013.01.026

    authors: Renner FC,Dietrich H,Bulut N,Celik D,Freitag E,Gaertner N,Karoui S,Mark J,Raatz C,Weimer R,Feustel A

    更新日期:2013-05-01 00:00:00

  • Detection of citrate synthase autoantibodies in rats with chronic allograft nephropathy.

    abstract:UNLABELLED:Citrate synthase (CS) is the one of the key enzymes in the citric acid cycle and an important mitochondrial autoantigen. The autoimmune responses against CS have not been studied in chronic allograft nephropathy (CAN). This study investigated the role of specific CS autoantibodies in rats bearing renal allog...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.08.071

    authors: Zhang LY,Lu YP,Yang L,Luo GH,Song J,Li YP

    更新日期:2009-12-01 00:00:00

  • Living Donor Liver Transplantation in a Patient With Extensive Portomesenteric Venous Thrombosis: Case Report.

    abstract::Extensive portomesenteric venous thrombus preventing restoration of adequate portal venous flow used to be considered a contraindication to liver transplantation. The subject was a 49-year-old male with hepatitis B cirrhosis and extensive thrombosis of portal, splenic, and superior mesenteric veins, and two large coll...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.03.029

    authors: Choi S,Kim KK,Lee WS,Kang JM,Park YH

    更新日期:2016-11-01 00:00:00

  • Risk factors for the development of new-onset diabetes mellitus in a living related renal transplant program.

    abstract::New-onset diabetes mellitus is associated with considerable morbidity after transplantation. We evaluated 78 living related renal transplant recipients due to all causes except diabetic nephropathy a waiting a living related renal transplantation. We evaluated demographic characteristics, pretransplant glycemic profil...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.10.008

    authors: Bora GS,Guleria S,Reddy VS,Tandon N,Gupta N,Gupta S,Bhowmik D

    更新日期:2010-12-01 00:00:00

  • The decrease in cytokine concentration during albumin dialysis correlates with the prognosis of patients with acute on chronic liver failure.

    abstract:BACKGROUND AND AIM:The clearance of plasma cytokines by means of albumin dialysis (MARS) has been demonstrated in various studies involving patients affected by either acute liver failure (ALF) or acute on chronic liver failure. The aim of the study was to measure the plasma levels of TNF-alpha, IL-6, and IL-1beta in p...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.06.040

    authors: Di Campli C,Zocco MA,Gaspari R,Novi M,Candelli M,Santoliquido A,Flore R,Tondi P,Proietti R,Gasbarrini G,Pola P,Gasbarrini A

    更新日期:2005-07-01 00:00:00

  • Cytotoxic T Lymphocyte-associated Protein 4 Acts on Local Draining Lymph Nodes in the Allogeneic Abdominal Skin Flap of a Rat Model to Extend Its Survival.

    abstract:BACKGROUND:Early acute allograft rejection is the result of immune cells mainly composed of thymocyte (T) cells, which are activated, mature, and differentiate in lymphoid tissue. METHODS:Cytotoxic T lymphocyte-associated protein 4 immunoglobulin (CTLA4-Ig) competitively suppresses the cluster of differentiation 28/CT...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.10.024

    authors: Ma G,Pei J,Li Y,Han Y,Liu D

    更新日期:2016-12-01 00:00:00