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Factors influencing the vaccinia-specific cytotoxic response of thymocytes from normal and chimeric mice.

Abstract：

:Following adoptive transfer into irradiated recipients, thymocytes can be induced to respond strongly to vaccinia virus. High levels of cytotoxic T-lymphocyte (CTL) activity may be generated from thymus, but not from spleen, of 3-day-old mice. The capacity of thymocytes to differentiate into effector CTL tends to be lost with age. Some of this loss may reflect positive suppression: a single, low dose of cyclophosphamide allows the reemergence of responsiveness in at least one mouse strain. Thymocytes from [A leads to (A x B)F1] and [(A x B)F1 leads to A] chimeras show the response patterns that would by predicted from previous studies of lymph node and spleen cells. However, thymic function seems to be rapidly lost in the [A leads to (A x B)F1] Chimeras.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Doherty PC,Schwartz DH,Bennink JR,Korngold R

subject

Has Abstract

pub_date

1981-12-01 00:00:00

pages

1850-3

issue

4

eissn

0041-1345

issn

1873-2623

journal_volume

13

pub_type

杂志文章

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