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Use of cyclosporine in hematopoietic cell transplantation.

Abstract：

:Early attempts to perform successful allogeneic hematopoietic stem cell transplants were plagued by graft rejection and graft-versus-host disease, leading many investigators to lose hope that bone marrow transplantation could ever become a useful therapeutic approach in clinical medicine. Although many subsequent discoveries contributed to the successful transformation of this area of research into lifesaving therapy, there can be no doubt that the discovery of cyclosporine (CsA) constituted one of the major advances. Even today, more than 25 years after the first description of its use in humans, CsA remains one of the cornerstones of therapy for the majority of patients undergoing allogeneic hematopoietic cell transplantation (HCT). In this review we will recount the events that have established CsA as a foundation of HCT.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hogan WJ,Storb R

doi

10.1016/j.transproceed.2004.01.043

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

367S-371S

issue

2 Suppl

eissn

0041-1345

issn

1873-2623

pii

S0041134504000259

journal_volume

36

pub_type

杂志文章,评审

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