Abstract:
BACKGROUND:The incidence of end-stage renal disease (ESRD) after liver transplant (LT) has increased. The actual benefit of kidney transplantation (KT) is not completely understood in LT recipients with ESRD. METHODS:We analyzed Scientific Registry of Transplant Recipients data for all KT candidates with prior LT from 1998 to 2014; the benefits of KT relative to remaining on dialysis were compared by means of multivariate Cox proportional hazards regression analysis. RESULTS:The number of these KT candidates with prior LT has tripled from 98 in 1998 to 323 in 2015; LT recipients with ESRD remaining on dialysis have a 2.5-times increase in the risk of liver graft failure and a 3.6-times increase in the risk of patient death compared with these patients receiving KT. The adjusted liver graft and patient survival rates after donors from donation after cardiac death or expanded-criteria donor kidney transplantation were significantly higher than in patients remaining on dialysis in LT recipients with ESRD. CONCLUSIONS:The number of referrals to KT with prior LT is increasing at a rapid rate. Remaining on dialysis in LT recipients with ESRD has profound increased risks of liver graft failure and patient death in comparison to receiving a KT. LT recipients with ESRD can benefit from expanded-criteria donor and donation after cardiac death kidney transplantation.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Yunhua T,Qiang Z,Lipeng J,Shanzhou H,Zebin Z,Fei J,Zhiheng Z,Linhe W,Weiqiang J,Dongping W,Zhiyong G,Xiaoshun Hdoi
10.1016/j.transproceed.2017.11.009subject
Has Abstractpub_date
2018-01-01 00:00:00pages
202-210issue
1eissn
0041-1345issn
1873-2623pii
S0041-1345(17)30826-6journal_volume
50pub_type
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