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Respiratory distress syndrome caused by influenza H1N1 in a patient with a simultaneous pancreas-kidney transplantation.

Abstract：

:Adult respiratory distress syndrome is a severe respiratory failure due to noncardiogenic pulmonary edema with high mortality rates (50-70%). The most common etiology of respiratory distress is sepsis, but it may also be caused by several of the immunosuppressants prescribed in transplantation. In the last year, influenza H1N1 virus infection has become more relevant. It has shown a greater incidence among immunosuppressed patients as well as those with chronic kidney disease or diabetes mellitus. We present the case of a patient with simultaneous pancreas-kidney transplantation who presented respiratory distress after the second dose of thymoglobulin. Initially, we interpreted that the thymoglobulin was the cause, so it was replaced with basiliximab. Empirical treatment was started with 3 doses of 6-methylprednisolone (250 mg), with a favorable response. After 7 days, we received the results of the reverse-transcriptase polymerase chain reaction of a nasal smear and blood culture, which were positive for H1N1 virus. In our knowledge, this is the first reported case of a patient with simultaneous pancreas-kidney transplantation and respiratory distress secondary to H1N1 virus infection who showed a favorable response to corticosteroid therapy.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Fraile P,Muñoz-Bellvis L,Cacharro LM,García-Cosmes P,Tabernero JM

doi

10.1016/j.transproceed.2013.06.015

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

3429-31

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00756-2

journal_volume

45

pub_type

杂志文章

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