当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up.

Lack of Relationship Between Renal Function and Genetic Variants of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT1A8, and UGT2B7 in Patients After Liver Transplantation in a 2-Year Follow-up.

Abstract：

BACKGROUND:The prolonged survival time after liver transplantation (LTX) creates the possibility of the occurrence and development of complications in the late post-transplantation period. Deterioration of renal function is 1 of these complications. The nephrotoxicity of calcineurin inhibitors (CNIs) and their metabolites produced during pharmacokinetic processes in the body is also postulated. The study was aimed at assessment of the relationship between selected single gene polymorphisms (SNPs) for enzymes and transport proteins and change of estimated glomerular filtration rate (ΔeGFR) during 2-year follow-up in LTX patients. METHODS:The study involved 244 patients after LTX (105 women [43.0%] and 139 men [57.0%]) receiving tacrolimus (191; 78.3%) or cyclosporine A (53; 21.7%). The study protocol conforms with the Declaration of Helsinki. RESULTS:We have not observed significant differences of ΔeGFR between groups distinguished based on analyzed genotypes in patients treated with cyclosporine or tacrolimus. CONCLUSION:Genetic variations of CYP3A4, CYP3A5, MDR1, MRP2, UGT1A9, UGT2B7, and UGT2B7 tested in LTX recipients are not associated with kidney function during the 24-month follow-up.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hryniewiecka E,Zegarska J,Zochowska D,Pączek L

doi

10.1016/j.transproceed.2020.01.096

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

2487-2491

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(19)31654-9

journal_volume

52

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Correlation between the kinetics of CD3+ chimerism and the incidence of graft-versus-host disease in patients undergoing allogeneic hematopoietic stem cell transplantation.

    abstract：INTRODUCTION:Graft-versus-host disease (GvHD) remains a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT). Early diagnosis and treatment may improve patient outcomes. A prospective study to investigate the relationship between chimerism kinetics and the development of acute or chr...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.02.011

    authors： Rupa-Matysek J,Lewandowski K,Nowak W,Sawiński K,Gil L,Komarnicki M

    更新日期：2011-06-01 00:00:00

  • Initial report of the Korean Organ Transplant Registry: the first report of national kidney transplantation data.

    abstract：PURPOSE:A national organ transplant registry is an indispensable organizational requirement for patient care, research, and planning. Even though the Korean Network for Organ Sharing (KONOS) has established a database for a waiting list, organ allocation, and incidence of organ transplantation since 2000, an integrated...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.11.083

    authors： Ahn C,Koo TY,Jeong JC,Kim M,Yang J,Lee J,Min SI,Lee JE,Kim MS,Kwon OJ,Kim SJ,Kim YH,Kim YH,Choi BS,Choi SJ,Lee DH,Chung SY,Cho WH,Kim YS,Korean Organ Transplantation Registry Study Group.

    更新日期：2014-01-01 00:00:00

  • Donor-Derived Cell-Free DNA Is a Novel Universal Biomarker for Allograft Rejection in Solid Organ Transplantation.

    abstract：BACKGROUND:In solid organ transplantation, sensitive real-time biomarkers to assess the graft health are desirable to enable early intervention, for example, to avoid full-blown rejections. During rejection, high amounts of graft-derived cell-free DNA (GcfDNA) are shed into the blood stream. The quantification of this ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.08.035

    authors： Beck J,Oellerich M,Schulz U,Schauerte V,Reinhard L,Fuchs U,Knabbe C,Zittermann A,Olbricht C,Gummert JF,Shipkova M,Birschmann I,Wieland E,Schütz E

    更新日期：2015-10-01 00:00:00

  • Early renal transplantation after donor renal angiography affects initial graft function.

    abstract：BACKGROUND:Renal angiography of a living donor is a common radiologic examination before transplantation. However, the contrast agent used during this procedure can cause contrast nephropathy. There are insufficient data regarding whether this radiocontrast exposure detoriates renal function and survival after transpla...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.01.122

    authors： Tutal E,Canver B,Can S,Colak T,Sezer S,Haberal M

    更新日期：2012-06-01 00:00:00

  • Impact of ABO-incompatible donor on early and late outcome of hematopoietic stem cell transplantation.

    abstract：:ABO incompatibility is not a barrier to allogeneic hematopoietic stem cell transplantation (HSCT). However, the impact of an ABO mismatch on the outcome of the HSCT remains controversial. We analyzed whether ABO incompatibility leads to an increased risk of early/late complications, mortality, or increased transfusion...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.189

    authors： Ozkurt ZN,Yegin ZA,Yenicesu I,Aki SZ,Yagci M,Sucak GT

    更新日期：2009-11-01 00:00:00

  • Thymoglobulin and rate of infectious complications after transplantation.

    abstract：UNLABELLED:Thymoglobulin is used as an induction agent in kidney transplantation, but the optimal dose is not well established. However, its use may be associated with increased infectious complications after transplantation. METHODS:This retrospective study of 61 high-risk renal recipients of transplants from decease...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.01.024

    authors： Clesca P,Dirlando M,Park SI,García R,Ferraz E,Pinheiro-Machado PG,Kushnaroff L,Tedesco-Silva H Jr,Medina-Pestana JO

    更新日期：2007-03-01 00:00:00

  • Predominant inhibition of interleukin-6 synthesis in patient-specific endothelial cells by mTOR inhibitors below a concentration range where cell proliferation is affected and mitotic arrest takes place.

    abstract：UNLABELLED:Organ rejection and inflammation are accompanied by endothelial cell activation. An in vitro model with patient-specific endothelial cells was used to study the impact of mTOR inhibitors on cell growth and release of proinflammatory cytokines. MATERIAL AND METHODS:Confluent monolayers of human saphenous vei...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.140

    authors： Lehle K,Birnbaum DE,Preuner JG

    更新日期：2005-01-01 00:00:00

  • Effects of cholesteryl ester transfer protein TAQ1B polymorphism in renal transplant patients.

    abstract：BACKGROUND:Dyslipidemia is an important complication in renal transplant patients. Cholesteryl ester transfer protein (CETP) mediates the exchange of cholesteryl ester between high density lipoproteins and low density lipoproteins. The aim of this study was to investigate CETP Taq1B gene polymorphism and lipid abnormal...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.03.039

    authors： Zeybek U,Isbir T,Ergen HA,Yilmaz H,Hekim N,Akoglu E

    更新日期：2006-06-01 00:00:00

  • Calcineurin-inhibitor-sparing immunosuppressive protocols.

    abstract：:Calcineurin inhibitors (CNI) have played an important role in improving graft survival. However, the balance between preventing immunologic allograft losses and the management of CNI-related nephrotoxicity is still an issue in renal transplantation. There are three major CNI-sparing strategies. CNI MINIMIZATION: The a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2005.09.129

    authors： Bestard O,Cruzado JM,Grinyó JM

    更新日期：2005-11-01 00:00:00

  • Pulmonary tuberculosis in an HIV- and hepatitis C virus-coinfected kidney-pancreas transplant recipient: a case report.

    abstract：:Tuberculosis (TB) is a serious infection in immunocompromised patients, such as solid organ transplant recipients and HIV-infected patients. The diagnosis and treatment in this population present several challenges because of the aspecific clinical manifestations, the difficulty in diagnosis, and the choice of the mos...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.02.050

    authors： Dalla Gasperina D,Tozzi M,Astuti N,Balsamo ML,Donati D,Rossi A,Dionigi R,Grossi PA

    更新日期：2011-05-01 00:00:00

  • Changes in Muscle Strength and Six-Minute Walk Distance Before and After Living Donor Liver Transplantation.

    abstract：BACKGROUND:Impaired exercise capacity and muscle weakness are important characteristics of liver transplantation recipients. Perioperative rehabilitation has been introduced to promote early mobilization of patients and to prevent postoperative pulmonary complications. However, it is unknown how physical status recover...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.08.042

    authors： Mizuno Y,Ito S,Hattori K,Nagaya M,Inoue T,Nishida Y,Onishi Y,Kamei H,Kurata N,Hasegawa Y,Ogura Y

    更新日期：2016-12-01 00:00:00

  • Effect of orange and tangerine juice on cyclosporine levels in renal transplant recipients.

    abstract：INTRODUCTION:Cyclosporine Neoral is a major immunosuppressive agent widely used in organ transplant populations. Its pharmacokinetics are influenced by various factors. The aim of this study was to investigate the effects of orange or tangerine juice on the pharmacokinetic pattern of cyclosporine Neoral among renal tra...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.040

    authors： Sorkhi H,Oliaei F,Moghadamnia AA,Pouramin M,Firoozjahi AR

    更新日期：2007-05-01 00:00:00

  • Orthotopic abdominal multivisceral transplantation without venovenous bypass in pigs.

    abstract：BACKGROUND:Because venovenous bypass (VVB) can cause specific complications, a simplified orthotopic abdominal multivisceral transplantation (MVTX) technique without VVB in pigs has been evaluated in terms of morbidity and mortality. MATERIALS AND METHODS:Outbred large-white pigs weighing 25 to 40 kg of random sex und...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.215

    authors： Ai LM,Peng CH,Wu YL,Cao LP,Fang HQ,Liu YB,Peng SY

    更新日期：2007-01-01 00:00:00

  • The treatment of deep vein thrombosis immediately after kidney transplantation: a case report.

    abstract：:Ipsilateral acute iliofemoral deep vein thrombosis (DVT) immediately after kidney transplantation is rare but highly morbid, resulting in allograft failure, rupture, or even death. Treatment modalities for iliofemoral DVT occurring just after transplantation are limited due to bleeding risk and impaired renal function...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.05.041

    authors： Hwang JK,Chun HJ,Moon IS,Kim JI

    更新日期：2011-07-01 00:00:00

  • Hepatocellular carcinoma downstaging in liver transplantation.

    abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the leading malignant tumor in Taiwan. The majority of HCC patients are diagnosed in late stages and therefore in eligible for potentially curative treatments. Locoregional therapy has been advocated as an effective treatment for patients with advanced HCCs. PURPOSE:The aim...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.01.043

    authors： Yu CY,Ou HY,Huang TL,Chen TY,Tsang LL,Chen CL,Cheng YF

    更新日期：2012-03-01 00:00:00

  • Anesthesia for ventricular assist device placement in pediatric patients: experience from a single center.

    abstract：BACKGROUND:The use of a ventricular assist device (VAD) as a bridge to heart transplantation in the pediatric population has evolved over the past decades This article presents our institution's clinical experience in the anesthetic management of pediatric patients with end-stage heart failure who underwent implantatio...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.02.068

    authors： Kocabas S,Askar FZ,Yagdi T,Engin C,Ozbaran M

    更新日期：2013-04-01 00:00:00

  • Comparison of postoperative morphine requirements in healthy living liver donors, patients with hepatocellular carcinoma undergoing partial hepatectomy, and liver transplant recipients.

    abstract：OBJECTIVE:To retrospectively evaluate postoperative morphine requirements in healthy living donors undergoing partial hepatectomy and patients with end-stage hepatocellular carcinoma or end-stage liver disease undergoing liver transplantation. PATIENTS AND METHODS:The study included all patients who received intraveno...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.024

    authors： Chen JP,Jawan B,Chen CL,Wang CH,Cheng KW,Wang CC,Concejero AM,Villagomeza E,Huang CJ

    更新日期：2010-04-01 00:00:00

  • Can liver transplantation achieve similar effects at high altitudes compared with plains: case report.

    abstract：:In orthotopic liver transplantation, particular emphasis must be placed on the unique physiologic, pathologic, and clinical features in residents living in areas at high vs low altitude. Hypobaric hypoxia, hypothermia, heavy radiation, high wind speed, and superevaporation at high altitudes may lead to various disease...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.01.115

    authors： Jin S,Chen Z,Lunan Y,Zeng Y,Wen T,Li B,Zhao J,Wang W,Xu M,Yang J

    更新日期：2009-06-01 00:00:00

  • Steroid-free immunosuppression after liver transplantation does not increase the risk of graft fibrosis.

    abstract：BACKGROUND:Steroid-free immunosuppression after liver transplantation (OLT) is effective and safe in the short and mid terms. However, research has shown a higher risk for late fibrosis among pediatric liver transplant recipients who have steroids withdrawn. Our aim was to test this hypothesis in the adult population. ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.03.118

    authors： Manzia TM,Toti L,Angelico R,Di Cocco P,Orlando G,Tisone G

    更新日期：2010-05-01 00:00:00

  • Assessment of Pulmonary Hypertension in Lung Transplantation Candidates: Correlation of Doppler Echocardiography With Right Heart Catheterization.

    abstract：BACKGROUND:Right heart catheterization (RHC) remains the gold standard to diagnosis of pulmonary hypertension among lung transplantation candidates. Doppler echocardiography (DE) may be as accurate as RHC, without risks of an invasive test. The aim of the study was to assess the feasibility of DE for the measurement of...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.06.055

    authors： Balcı MK,Arı E,Vayvada M,Salturk C,Aşıcıoğlu E,Kahveci G,Akbal ÖY,Kutlu CA

    更新日期：2016-10-01 00:00:00

  • A risk score and a flowchart for liver retransplantation.

    abstract：:Rates of overall graft survival after liver retransplantation (RETX) are still 20% lower than those after primary liver transplantation (TX). On the basis of previous mathematical approaches from other authors who tried to identify prognostic variables for survival and prognostic risk scores for liver RETX, we studied...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.05.057

    authors： Maggi U,Consonni D,Bertoli P,Caccamo L,Reggiani P,Melada E,Rossi G

    更新日期：2008-07-01 00:00:00

  • Impact of immunosuppression on the development of Epstein-Barr virus (EBV) viremia after pediatric liver transplantation.

    abstract：OBJECTIVES:Pediatric liver transplant (OLT) patients are at risk of posttransplant lymphoproliferative disease (PTLD) from Epstein-Barr virus (EBV). This study examined the impact of induction and immunosuppression on EBV viremia. METHODS:A retrospective chart review was performed on 197 pediatric patients and inducti...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.04.035

    authors： Lu BR,Park KT,Hurwitz M,Cox KL,Berquist WE

    更新日期：2013-01-01 00:00:00

  • Aggressive management of multiorgan donor.

    abstract：:Transplantation of vital human organs is a lifesaving therapy for patients with end-stage organ failure who are medically fit to undergo the surgical procedure. However, deceased donor management remains one of the most neglected areas in transplantation medicine. Brainstem death leads to hemodynamic, metabolic, and i...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.03.029

    authors： Shah VR

    更新日期：2008-05-01 00:00:00

  • Cryopreservation of immobilized rat hepatocytes for the development of a bioartificial liver system.

    abstract：:Liver transplantation, the only effective treatment for end-stage disease, is limited by donor availability. Cell transplantation offers the possibility to restore liver mass and function. Cryopreserved primary hepatocytes that can be thawed as needed might address this problem. Hepatocytes were harvested from a male ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.03.050

    authors： Lee JH,Park JH,Park HJ,General T,Cho MG,Lee SK

    更新日期：2012-05-01 00:00:00

  • Retransplantation of the liver: review of current literature for decision making and technical considerations.

    abstract：:Liver transplantation (LTx) is an established treatment modality for patients with end-stage liver disease, metabolic disorders, and patients with acute liver failure. When a graft fails after primary LTx, retransplantation of the liver (reLTx) is the only potential cure. ReLTx accounts for 7%-10% of all LTx in the Un...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2013.02.063

    authors： Yoo PS,Umman V,Rodriguez-Davalos MI,Emre SH

    更新日期：2013-04-01 00:00:00

  • Effect on Dosage Change and Intrapatient Variability After Conversion From Twice-Daily to Once-Daily Tacrolimus Among Thai Kidney Transplant Patients With and Without CYP3A4/5 Inhibitors.

    abstract：BACKGROUND:Converting to once-daily tacrolimus (Advagraf [Adv]) among renal transplant patients results in better drug adherence. Data regarding dosage and intrapatient variability changes after conversion among patients with CYP3A4/5 inhibitors (CYPinh) is lacking. METHOD:A retrospective chart review among all kidney...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.02.065

    authors： Larpparisuth N,Skulratanasak P,Vongwiwatana A,Premasathian N

    更新日期：2019-10-01 00:00:00

  • C-terminal peptide of anaphylatoxin C3a enhances hepatic function after steatotic liver transplantation: a study in a rat model.

    abstract：BACKGROUND:C3a, a complement component stimulates hepatocyte proliferation. In this study, we investigated whether a functional peptide from its C terminal, YAAALGLAR (C3aP), enhanced liver function after steatotic liver transplantation in a rat model. METHODS:Livers of Sprague-Dawley (SD) rats fed a high-fat diet for...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.03.028

    authors： Xu XH,Peng HS,Sun MQ,Hu M,Zhang R,Wang WH,He XY,Xiao XR

    更新日期：2010-04-01 00:00:00

  • Effect of posttraumatic donor's disseminated intravascular coagulation in intrathoracic organ donation and transplantation.

    abstract：INTRODUCTION:Our aim was to evaluate the influence on yield and function of intrathoracic organs from donors after severe cranial trauma complicated by disseminated intravascular coagulation (DIC). MATERIALS AND METHODS:This retrospective observational study in a patient cohort with severe cranial trauma reading to br...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.07.052

    authors： Valdivia M,Chamorro C,Romera MA,Balandín B,Pérez M

    更新日期：2007-09-01 00:00:00

  • Cancer in renal allograft recipients in Australia and New Zealand.

    abstract：:Total incidence and outcome of cancer in all renal allograft recipients in one geographic area are known: 126 (7%) of 1884 patients developed cancer during an 11-year period. Proportions with cancer 1 and 5 years following successful transplantation were 11% and 24%, respectively. Numbers, proportion of malignancies, ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Sheil AG

    更新日期：1977-03-01 00:00:00

  • Effects of tolerance induction on the actions of interferon-gamma on porcine cardiac allografts.

    abstract：:It is well known that interferon-gamma (IFN-gamma) not only plays a critical role in antigen-dependent but also in antigen-independent tissue injury; however, it is not clear how tolerance induction affects the actions of IFN-gamma in the transplant setting. To address this question, we compared the effects of IFN-gam...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.119

    authors： Hoerbelt R,Benjamin LC,Shoji T,Johnston DR,Muniappan A,Guenther DA,Allan JS,Houser SL,Madsen JC

    更新日期：2006-12-01 00:00:00