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Factors Affecting Recurrence and Survival After Liver Transplantation for Hepatocellular Carcinoma.

Abstract：

INTRODUCTION:Liver transplantation (LT) remains the best treatment option for hepatocellular carcinoma (HCC). Patient selection is crucial and debated ever since the emerging of the Milan criteria in 1996. As live-donor LT is being more routinely performed worldwide, numerous new and/or expansions of the original criteria have been suggested to allow more patients to benefit from this superior treatment modality. This study aims to contribute to the ever-growing data in search for better coverage of patients with acceptable outcomes. METHODS:Medical recordings of 187 adult patients who underwent LT for HCC in a 6-year period were retrospectively collected. Patients were classified by Milan and University of California, San Francisco, criteria. Survival times as well as tumor, liver disease, and recurrence-related data were recorded for each patient and the outcomes were statistically analyzed. RESULTS:Factors significantly affecting recurrence and survival were histologic differentiation, number and the size of the tumor, and the presence of vascular invasion. Serum alpha-fetoprotein levels did not significantly affect outcomes. Among the patients exceeding both of the criteria, having a total tumor size of less than 160 mm was significantly associated with better outcomes (P = .007). CONCLUSION:HCC patients having tumors with vascular invasion, poor differentiation, exceeding 6 in number and 160 mm in total diameter demonstrate higher recurrence rates and worse outcomes.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Yilmaz C,Karaca CA,Iakobadze Z,Farajov R,Kilic K,Doganay L,Kilic M

doi

10.1016/j.transproceed.2018.05.027

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

3571-3576

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30732-2

journal_volume

50

pub_type

杂志文章

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