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Thymoglobulin and rate of infectious complications after transplantation.

Abstract：

UNLABELLED:Thymoglobulin is used as an induction agent in kidney transplantation, but the optimal dose is not well established. However, its use may be associated with increased infectious complications after transplantation. METHODS:This retrospective study of 61 high-risk renal recipients of transplants from deceased donors performed between June 2001 and April 2004 included patients treated with thymoglobulin. Patients were divided into two groups according to the total thymoglobulin dose (G1, n = 30, <7 mg/kg; G2, n = 31, >7 mg/kg) and followed for at least 1 year. RESULTS:Mean recipient age was 43 +/- 14 years; 41% were males; 63% non-Whites. Mean cold ischemia time was 26.3 +/- 7 hours. Mean PRA was 23% (0-100%). Second transplantation was performed in 18 (29.5%) patients. Mean donor age was 42.1 +/- 16 years, and 59% had a cerebral vascular accident as the cause of death. Patient- and death-censored graft survival at 12 months were 86% and 88%, respectively. There were 149 infectious episodes among 47 (78%) patients. The incidence of infection was 1.7 +/- 0.24 infections per patient per year in G1 (lower dose) vs 3.12 +/- 0.23 in G2 (P < .001). Bacterial (0.66 +/- 1.0 vs 1.48 +/- 1.26 infections per patient per year, P = .009) and viral infections (0.9 +/- 0.71 vs 1.41 +/- 0.71; P = .006) were more frequent in the higher dose group. CONCLUSION:This study suggested that a greater number of infectious episodes were present when the total dose of thymoglobulin was higher than 7 mg/kg.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Clesca P,Dirlando M,Park SI,García R,Ferraz E,Pinheiro-Machado PG,Kushnaroff L,Tedesco-Silva H Jr,Medina-Pestana JO

doi

10.1016/j.transproceed.2007.01.024

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

463-4

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)00064-4

journal_volume

39

pub_type

杂志文章

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