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Prophylaxis of recurrent hepatitis B virus by vaccination after liver transplant: preliminary results.

Abstract：

:Liver transplantation for chronic HBV-induced cirrhosis is associated with a high rate of recurrence and poor long-term survival. Prolonged and combined prophylaxis with hepatitis B immunoglobulin (HBIg) and lamivudine has been demonstrated to prevent HBV recurrence, but its lifelong administration is highly expensive. An alternative strategy may be the use of an HBV vaccine after liver transplantation. Herein we report the results of administration of a reinforced recombinant HBV vaccine to liver transplant recipients. Twelve patients transplanted for HBV-related liver disease and treated with HBIg for at least 24 months were administered HBV vaccine (40 microg administered intramuscularly and repeated 1 and 2 months thereafter) 2 months after beginning the last HBIg dose. The response rate to HBV vaccination was 75% (9/12 patients). Serum titers of anti-HBs were considered to be protective when they reached levels >10 IU/L. Responding patients were followed for a median of 43+/-22.5 months; during this period none of the responders showed evidence of HBV recurrence. These results suggest that vaccine administration after liver transplant may avoid HBV recurrence allowing HBIg withdrawal. However, future studies are necessary to define an optimal schedule.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Albeniz Arbizu E,Barcena Marugan R,Oton Nieto E,Carrera Alonso E,Garcia Gonzalez M,Moreno Garcia J,de Vicente Lopez E,Nuño Vazquez-Garza J,Martin Davila P

doi

10.1016/s0041-1345(03)00633-x

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

1848-9

issue

5

eissn

0041-1345

issn

1873-2623

pii

S004113450300633X

journal_volume

35

pub_type

杂志文章

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