Abstract:
BACKGROUND:With increasing graft survival, post-transplant immunoglobulin A nephropathy (IgAN) has emerged as an important cause of chronic graft dysfunction in renal allograft recipients. We studied the clinico-pathological features of post-transplant IgAN regardless of the primary disease. The aim was to study the usefulness of the Oxford classification in predicting survival. METHODS:Indication graft biopsy specimens (n = 915) were received during a 10-year period; 27 biopsy specimens from 22 patients were diagnosed as IgAN. RESULTS:Post-transplant IgAN was seen in 2.6% of biopsy specimens. Mean time to occurrence was 71.6 ± 47.6 months (range, 6.8 months to 16 years), occurring most commonly 4 to 8 years after transplant. Associated rejection was present in 4 biopsies; 72.7% (16/22), 91% (20/22), and 31.8% (7/22) presented with rise in serum creatinine, proteinuria, and hematuria, respectively. Four (21%) patients had nephrotic range proteinuria. Mesangial hypercelullarity (M1), endocapillary hypercelullarity (E1), segmental glomerulosclerosis (S1), and tubulo-interstitial fibrosis (T1-2) was present in 36.6%, 22.7%, 54.5%, and 31.8% biopsies, respectively. The most frequent Haas class was III (n = 7; 29.1%), followed by classes IV and I (n = 5; 20.8% each). The 2- and 5-year graft survival rates were 75% and 56%, respectively. High serum creatinine, low estimated glomerular filtration rate, E1 and T lesions, and degree of interstitial inflammation predicted graft survival. Interestingly, percentage (>25%) of segmentally sclerosed glomeruli and not S1 correlated with graft outcome. CONCLUSIONS:The Oxford MEST scheme is useful in predicting graft survival in post-transplant IgAN. The degree of interstitial inflammation is also an important feature for determining graft outcomes in post-transplant IgAN.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Agrawal V,Singh A,Kaul A,Verma R,Jain M,Pandey Rdoi
10.1016/j.transproceed.2017.10.002subject
Has Abstractpub_date
2017-12-01 00:00:00pages
2274-2279issue
10eissn
0041-1345issn
1873-2623pii
S0041-1345(17)30718-2journal_volume
49pub_type
杂志文章abstract:BACKGROUND:De novo malignancy is not uncommon after liver transplantation (LT). Gastric cancer is one of the most common malignancies in both the Korean general population and LT recipients, and colorectal cancer prevalence is gradually increasing. METHODS:Among 3690 adult recipients who underwent LT from January 1999...
journal_title:Transplantation proceedings
pub_type: 杂志文章,多中心研究
doi:10.1016/j.transproceed.2015.12.003
更新日期:2016-01-01 00:00:00
abstract::Ventricular assist devices (VAD) have benefitted patients with end-stage heart failure as a bridge to heart transplantation (HTx). We present our experience with HTx after an extracorporeal membrane oxygenation (ECMO) hybrid with various ventricular assist devices (VAD). From May 1996 to December 2003, mechanical circ...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2006.06.052
更新日期:2006-09-01 00:00:00
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journal_title:Transplantation proceedings
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abstract:INTRODUCTION:Intestinal manipulation leads to local bowel wall inflammation that subsequently spreads over the entire gastrointestinal tract. Previously, this gastrointestinal field effect had been demonstrated by us in a rodent model. We herein postulated an immunologic mechanism mediated by activated leukocytes. The ...
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pub_type: 杂志文章
doi:10.1016/j.transproceed.2006.06.087
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Heart transplantation is a treatment option for children as well as for adults with congenital heart disease. OBJECTIVE:To report the experience of a tertiary center with heart transplant program in pediatric population and in adults with congenital heart disease. PATIENTS AND METHODS:The study consisted o...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2014.05.050
更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2005-12-01 00:00:00
abstract::Pseudoaneurysm is a rare vascular complication in pancreas transplantation that can lead into life-threatening situations. A 44-year-old male patient after simultaneous pancreas-kidney transplant was admitted to the hospital for routine tests 3 months after surgery. A computed tomography scan and ultrasound examinatio...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2020.02.108
更新日期:2020-10-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2014.08.037
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journal_title:Transplantation proceedings
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更新日期:2011-03-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2008.04.013
更新日期:2008-06-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.01.011
更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2014.05.010
更新日期:2014-07-01 00:00:00
abstract::Pancreas and kidney transplantation is the treatment of choice for patients with type 1 diabetes mellitus and terminal renal insufficiency. Herein we have presented a series of 35 patients transplanted between 2002 and 2009 including periods before and after 2007 divided based on introduction of some technical aspects...
journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2009.12.001
更新日期:2010-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2008.10.023
更新日期:2009-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-04-01 00:00:00
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更新日期:2009-07-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章,多中心研究
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更新日期:2005-07-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2015-05-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2008.10.036
更新日期:2009-01-01 00:00:00
abstract:UNLABELLED:Organ rejection and inflammation are accompanied by endothelial cell activation. An in vitro model with patient-specific endothelial cells was used to study the impact of mTOR inhibitors on cell growth and release of proinflammatory cytokines. MATERIAL AND METHODS:Confluent monolayers of human saphenous vei...
journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.01.033
更新日期:2007-03-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2007-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00