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Alleviating ischemia-reperfusion injury in aged rat liver by induction of heme oxygenase-1.

Abstract：

BACKGROUND:Heme oxygenase-1 (HO-1), a cytoprotective protein, may be important in ameliorating hepatic ischemia-reperfusion (I/R) injury, a critical factor in the dysfunction of the aged liver after transplantation. METHODS:We used hemin to overexpress HO-1 and analyze its effects in a model of I/R in aged livers used for orthotopic transplantation. RESULTS:The SGOT levels in the hemin group were significantly lower than those of the saline treatment group. Hemin liver grafts showed markedly fewer apoptotic (TUNEL+) liver cells after reperfusion compared with the controls. The plasma nitric oxide levels in the hemin group were significantly lower than those in the control group. Unlike untreated or hemin + Znpp-treated orthotopic liver transplant controls, iNOS expression in the hemin group was almost absent at 12 and 24 hours, after reperfusion. In contrast, eNOS was comparable in hemin and saline orthotopic liver transplants. The increased levels of Bcl-2 expression compared with saline controls were most pronounced at 12 hours after transplantation. In contrast, caspase 3 was lower at 24 hours among the hemin-pretreated group compared with saline-treated liver transplant controls. CONCLUSIONS:HO-1 alleviated the I/R injury in the aged liver by suppressing local expression of inducible nitric oxide synthase and by modulating pro- and antiapoptotic pathways.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Wang XH,Wang K,Zhang F,Li XC,Qian XF,Cheng F,Li GQ,Fan Y

doi

10.1016/j.transproceed.2004.10.066

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

2917-23

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)01265-5

journal_volume

36

pub_type

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