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Treatment-resistant recurrent membranoproliferative glomerulonephritis in renal allograft responding to rituximab: case report.

Abstract：

:We report a case of idiopathic membranoproliferative glomerulonephritis (MPGN) recurring 2 years after a living-unrelated kidney transplantation. The disease was refractory to intravenous immunoglobulin and plasmapheresis. Treatment with 2 doses of rituximab resulted in remission of the disease. The disease relapsed 18 months later after an episode of cytomegalovirus pneumonitis. After treatment of the pneumonitis, a lung biopsy was performed owing to persistent chest symptoms, which revealed bronchiolitis obliterans with organizing pneumonia. Bone marrow examination and culture revealed presence of acid-fast bacilli, and culture grew Mycobacterium tuberculosis. A repeated course of rituximab was withheld because of infection with tuberculosis, the patient's chest symptoms, and rare reports of noninfectious lung disease after the use of rituximab. The patient continues to have proteinuria with impaired kidney function.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Farooqui M,Alsaad K,Aloudah N,Alhamdan H

doi

10.1016/j.transproceed.2015.02.003

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

823-6

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)00106-2

journal_volume

47

pub_type

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