Response to transarterial chemoembolization in candidates with hepatocellular carcinoma within Milan criteria does not predict post-transplant disease-free survival.

Abstract:

INTRODUCTION:Few groups have studied the impact of pretransplant transarterial chemoembolization (TACE) in the outcomes of liver transplant recipients with hepatocellular carcinoma (HCC). We verified whether response to TACE in HCC candidates impacts post-transplant disease-free survival. METHODS:This a single center retrospective study of patients who underwent liver transplantation from 2006-2013. Included were those transplanted due to HCC within the Milan criteria who were treated with TACE in the pre-transplant period. Response to TACE followed the modified RECIST (mRECIST) criteria. Disease free-survival was the main endpoint of the study. RESULTS:We included 187 patients in this study. The population had an average age of 57.5 years, predominantly formed by men (82.5%), with an average IMC of 26.7, MELD of 13, with viral hepatitis as main cause of liver disease. Average waiting time was 253 days and follow-up was 27.3 months. Based on response to TACE, 3-year disease-free survival was 84.1% for those with complete response to TACE, 84.1% for those with partial response to TACE, 85.7% for those with stable disease and 100% for patients with progressive disease. Multivariate analysis did not identify response to TACE as a predictor of disease-free post-transplant survival. CONCLUSIONS:Response to TACE in candidates with HCC within Milan criteria does not predict post-transplant disease-free survival.

journal_name

Transplant Proc

authors

Salvalaggio PR,Felga GE,Alves JA,Meirelles RF Jr,Almeida MD,de Rezende MB

doi

10.1016/j.transproceed.2014.05.039

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1799-802

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00387-X

journal_volume

46

pub_type

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