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Bupropion reduces the inflammatory response and intestinal injury due to ischemia-reperfusion.

Abstract：

:Intestinal ischemia-reperfusion (I/R) causes severe organ failure and intense inflammatory responses, which are mediated in part by the cytokine tumor necrosis factor-alpha (TNF-alpha). Bupropion is an antidepressant known to inhibit TNF-alpha production. We sought to examine the protective effects of bupropion on intestinal I/R injury in 15 male Sprague-Dawley rats that were randomized to sham surgery, 45 minutes of intestinal ischemia followed by 180 minutes reperfusion, or bupropion (100 mg/kg) before the intestinal I/R injury. To evaluate the systemic inflammatory response induced by intestinal I/R, we measured serum levels of TNF-alpha, interleukins-1 and -6, lipid peroxidation, and transaminases. Histologic analysis evaluated intestinal injury using the Chiu muscosal injury score. After I/R, Chiu score in control animals was 3.6 ± 1.2 vs 2.6 ± 0.53 in animals that received bupropion (P < .05). Bupropion pretreatment reduced intestinal. I/R injury and blunted serum elevations of TNF-alpha (0.96 ± 1.1 ng/mL vs 0.09 ± 0.06 ng/mL, P < .05) and interleukin-1 (0.53 ± 0.24 ng/mL vs 0.2 ± 0.11 ng/mL, P < .05). Bupropion in reduced intestinal I/R injury through immunomodulatory machanisms that involve inflammatory cytokines such as TNF-alpha.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Cámara-Lemarroy CR,Guzmán-de la Garza FJ,Cordero-Pérez P,Alarcón-Galván G,Ibarra-Hernández JM,Muñoz-Espinosa LE,Fernández-Garza NE

doi

10.1016/j.transproceed.2013.04.010

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2502-5

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00523-X

journal_volume

45

pub_type

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