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Impairment in forearm endothelium-dependent vasodilation after heart transplantation.

Abstract：

BACKGROUND:Endothelial dysfunction has been found in the peripheral circulation of patients with severe heart failure. However, whether the endothelial dysfunction improves after heart transplantation remains unknown. Our aim was to assess the forearm endothelium-dependent vasoreactivity one and six months after heart transplantation. METHODS:We studied 12 patients using high resolution brachial artery ultrasound to assess flow-mediated dilation induced by reactive hyperemia and nitroglycerin induced dilation (NTGdil). RESULTS:One month after heart transplantation, endothelium-dependent vasodilation was significantly impaired in 10 patients (83%), while it was preserved in the remaining two (17%) (0.4%+/-2.4% vs 9.9%+/-4.6%, respectively, P=.001). NTGdil was normal in both groups (12%+/-10% vs 23%+/-5%, respectively, P=NS). At six months, endothelial dysfunction was present in all patients including the two patients without endothelial dysfunction at the first study. CONCLUSIONS:The present study demonstrates that peripheral endothelial dysfunction is present after heart transplantation despite the improvement in left ventricular function. More studies are needed to prove if endothelial dysfunction reversion may improve survival in heart transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Cuppoletti A,Sitges M,Pérez Villa F,Orús J,Magriñá J,Roig E

doi

10.1016/s0041-1345(03)00661-4

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

2011-3

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041134503006614

journal_volume

35

pub_type

杂志文章

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