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Steroid elimination-who, when, how?

Abstract：

:Steroids have numerous side effects, many occurring early posttransplantation with relatively low prednisone doses. Consequently, investigators have attempted steroid minimization or withdrawal. The first attempts at steroid minimization used early low-dose steroids and were associated with an increased rate of acute rejection episodes, late graft dysfunction, and graft loss. Subsequent studies, with cyclosporine-based immunosuppression, attempted steroid withdrawal late posttransplantation (>3 months) in highly selected, clinically well, and immunologically low-risk recipients. Again, steroid withdrawal was associated with an increased risk of acute rejection episodes and these episodes were associated with graft dysfunction and increased graft loss. The development of new powerful immunosuppressive agents has led to renewed attempts at late prednisone withdrawal. These also have been associated with increased late rejection risk. A more exciting innovation has been the attempts at rapid discontinuation (

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Matas AJ

doi

10.1016/j.transproceed.2008.10.007

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

S52-6

issue

10 Suppl

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)01359-6

journal_volume

40

pub_type

杂志文章,评审

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