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Rituximab as treatment of posttransplant lymphoproliferative disorder in patients who underwent small bowel/multivisceral transplantation: report of three cases.

Abstract：

:This report describes three cases of posttransplant lymphoproliferative disorder (PTLD) in multivisceral/small bowel transplant patients treated with rituximab (anti-CD20 monoclonal antibodies). In two cases (one of which was a B-cell lymphoma) a good response to therapy was achieved. A third case (with polymorphic PTLD with low CD20 expression) developed a refractory rejection and PTLD was still documented on graftectomy. Rituximab was well tolerated, and a reduction of Epstein-Barr virus (EBV) viral load was documented by quantitive competitive-EBV polymerase chain reaction. Efficacy of therapy needs to be assessed in controlled studies.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Codeluppi M,Cocchi S,Guaraldi G,Di Benedetto F,Bagni A,Pecorari M,Gennari W,Pinna AD,Gerunda GE,Esposito R

doi

10.1016/j.transproceed.2005.06.032

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

2634-5

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00672-X

journal_volume

37

pub_type

杂志文章

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