当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Association between urothelial carcinoma after kidney transplantation and aristolochic acid exposure: the potential role of aristolochic acid in HRas and TP53 gene mutations.

Association between urothelial carcinoma after kidney transplantation and aristolochic acid exposure: the potential role of aristolochic acid in HRas and TP53 gene mutations.

Abstract：

OBJECTIVE:We sought to investigate the association between urothelial carcinoma (UC) after kidney transplantation and aristolochic acid (AA) exposure, and to explore the potential role of AA in HRas and TP53 gene mutations. MATERIALS AND METHODS:UC was confirmed in 100 of 3790 patients who underwent kidney transplantation between January 1974 and May 2011. We retrospectively analyzed clinical data for these patients. Malignancies were identified in 136 patients (15 males and 85 females, of age range 27-71 years mean, 53.2±6.3). UC was the most common diagnosis (100/136; 73.5%). The median time from transplantation to the first confirmed diagnosis of a tumor was 34.5 months (range, 2-273). Polymerase chain reaction-based resequencing methods were used to detect mutations in the target regions of exons 2 and 3 of the HRas gene and exons 5, 6, 7, and 8 of the TP53 gene in 90 of 100 samples. RESULTS:UC was identified in 53 of 380 patients exposed to AA and 47 of 3410 patients not exposed to AA (P<0.05). Pathologic examination of the UC specimens from AA-exposed patients identified heterozygous HRas changes in 3 cases, and deletion or replacement mutations in the TP53 gene in 4. No genetic mutations were observed among the control group. CONCLUSION:UC after kidney transplantation significantly correlated with AA exposure; however, there seemed to be no significant difference in mutations in exons 2 and 3 of the HRas gene and those in exons 5, 6, 7, and 8 of the TP53 gene in terms of tumor development, a result that is inconsistent with previous studies.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Xiao J,Zhu X,Hao GY,Zhu YC,Hou HJ,Zhang J,Ma LL,Tian Y,Zhang YH

doi

10.1016/j.transproceed.2011.09.069

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

3751-4

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(11)01348-0

journal_volume

43

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Lower Platelet Count Following Rabbit Antithymocyte Globulin Induction Is Associated With Less Acute Cellular Rejection in Heart Transplant Recipients.

    abstract：BACKGROUND:Unlike lymphodepletion, a decrease in platelet count following induction immunosuppressive therapy with polyclonal rabbit antithymocyte globulin (rATG) is deemed as an adverse event. However, this phenomenon may represent a particular rATG antirejection mechanism. METHODS:This retrospective single-center st...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.02.172

    authors： Skoric B,Fabijanovic D,Pasalic M,Planinc AR,Botonjic H,Cikes M,Planinc I,Ljubas-Macek J,Gasparovic H,Milicic D

    更新日期：2021-01-01 00:00:00

  • Prognosis after liver transplantation predicted by preoperative MELD score.

    abstract：:The model for end-stage liver disease (MELD) has been an excellent predictor of 3-month mortality among cirrhotic patients awaiting orthotopic liver transplantation (OLT). The aim of this study was to evaluate whether the preoperative MELD score predicts short-term prognosis after OLT. We enrolled 98 adult liver trans...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.031

    authors： Kim DJ,Lee SK,Jo JW,Kim SJ,Kwon CH,Park JW,Han YS,Park JB

    更新日期：2006-09-01 00:00:00

  • Prognostic Value of Pre-transplantation Serum Alpha-Fetoprotein Levels in Hepatocellular Carcinoma Recurrence.

    abstract：:Serum alpha-fetoprotein (AFP) value is still not included in the consensus guidelines to make decisions referring to liver transplantation (LT) for hepatocellular carcinoma (HCC). Many studies demonstrated the influence of high AFP level in poor prognosis after LT for HCC. We studied 301 consecutive recipients transpl...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.07.033

    authors： Montalvá EM,Cantos M,Boscà A,Rubín A,Vinaixa C,Granero P,Maupoey J,López-Andújar R

    更新日期：2016-11-01 00:00:00

  • Excellent results of high-dose mizoribine combined with cyclosporine, basiliximab, and corticosteroids in renal transplant recipients--4-year results.

    abstract：BACKGROUND:Mizoribine (MZR) at 3 mg/kg/d shows less potent immunosuppressive effects, but high-dose MZR (6 mg/kg/d) was effective and safe in a 2-year study in conjunction with a regimen of cyclosporine (CsA), basiliximab, and corticosteroids. METHODS:We compared 40 living-related kidney recipients administered MZR (6...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.01.055

    authors： Yoshimura N,Ushigome H,Nobori S,Suzuki T,Sakai K,Koshino K,Okajima H,Okamoto M

    更新日期：2013-05-01 00:00:00

  • Updated status of deceased-donor liver graft allocation for high-urgency adult patients in a Korean high-volume liver transplantation center.

    abstract：BACKGROUND:The number of deceased organ donors in Korea has been gradually increased to reach 8 per million population. This study intended to analyze the updated status of urgent deceased-donor liver transplantation in a Korean high-volume liver transplantation center. METHODS:A retrospective study was performed with...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.02.014

    authors： Jung BH,Hwang S,Song GW,Jung DH,Ha TY,Park GC,Ahn CS,Moon DB,Kim KH,Kwang SH,Yoon YI,Shin MH,Kim WJ,Kang WH,Kim SH,Lim TW,Lee SG

    更新日期：2015-04-01 00:00:00

  • Comparison of 3 Explant-Based Prognostic Models as Predictors of Hepatocellular Carcinoma Recurrence After Liver Transplantation: Analysis of Our Experience.

    abstract：:Tumor load is often underdiagnosed on radiological examination previous to liver transplantation (LT) for hepatocarcinoma (CHC). Thus, post-liver transplant explant analysis is required following transplantation to assess the risk of the recurrence of CHC. The objectives were to compare the characteristics of CHC on p...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.03.132

    authors： Mirón Fernández I,León Díaz FJ,Sánchez Segura J,Sánchez Pérez B,Pérez Daga JA,Fernández Aguilar JL,Montiel Casado MC,Santoyo Santoyo J

    更新日期：2019-01-01 00:00:00

  • Impact of mycophenolate mofetil dose posttransplantation on 12-month renal function: analysis of the MOST database.

    abstract：INTRODUCTION:Mycophenolate mofetil (MMF) has greatly reduced the risk of acute rejection episodes (ARE) after renal transplantation, but dose reductions/withdrawals could jeopardize long-term results. METHODS:The MOST database of "de novo" patients treated with MMF at month 1 and functioning grafts at month 12 were di...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2005.06.053

    authors： Salvadori M,Bock A,Chapman J,Dussol B,Fritsche L,Kliem V,Lebranchu Y,Oppenheimer F,Pohanka E,Tufveson G,Rosati A,Puig X,Corbetta G,MOST International Study Group.

    更新日期：2005-07-01 00:00:00

  • Prograf five milligrams versus Tacrolimus medis in healthy volunteers: a bioequivalence study.

    abstract：:For FDA approval, bioequivalence of a generic version of Tacrolimus must be demonstrated in a randomized, two-treatments, two-periods, two-sequences, single-dose crossover study in healthy adult volunteers. Currently there are at least 3 differents generic equivalent for Tacrolimus, that are approved by the EMA and th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2013.08.104

    authors： Masri M,Rizk S,Boujbel L,Bellahirich W,Baassoumi D,Attia M,Matha V

    更新日期：2013-01-01 00:00:00

  • Prophylactic adenine arabinoside following marrow transplantation.

    abstract：:Interstitial pneumonia is a major cause of morbidity and mortality following allogeneic marrow transplantation for hematologic malignancy. In this prospective randomized study, 22 of 40 patients received prophylactic adenine arabinoside (Ara-A) at a dose of 5 mg/kg/day administered intravenously on an intermittent sch...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Kraemer KG,Neiman PE,Reeves WC,Thomas ED

    更新日期：1978-03-01 00:00:00

  • Is single-shot epidural analgesia more effective than morphine patient-controlled analgesia for donor nephrectomy?

    abstract：OBJECTIVE:We compared single-shot epidural analgesia (20 mL 0.125% levobupivacaine and 3 mg diamorphine) followed by regular tramadol versus morphine patient-controlled analgesia (PCA) for postoperative pain following donor nephrectomy. METHODS:We retrospectively evaluated 12 patients who received single-shot epidural...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.08.116

    authors： Milan Z,Das S,Kocarev M,Rawari V

    更新日期：2011-12-01 00:00:00

  • Cardiopulmonary transplantation service establishment in the 1990s: Australia--a developing country?

    abstract：:1. A National Transplantation Service has been established at the Alfred Hospital performing more than 50 transplants per year. 2. Increased access to transplantation technology has facilitated an improvement in national population servicing from 2.7 to 6.2 transplants per million population per year. National funding...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Esmore D,Williams T,Bergin P,Rosenfeldt F,Cochrane A,Griffiths A,Federman J

    更新日期：1992-10-01 00:00:00

  • Changes in Tumor Markers and Their Implications in Selecting Liver Transplantation for Patients With Hepatocellular Carcinoma.

    abstract：BACKGROUND AND AIM:It has been suggested that tumor markers can provide additional information over tumor size and number-based liver transplantation (LT) criteria. We aimed to assess if changes in tumor markers are associated with the risk of tumor recurrence after LT for hepatocellular carcinoma (HCC) who received lo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.01.037

    authors： Song BG,Sinn DH,Kang W,Gwak GY,Paik YH,Choi MS,Lee JH,Koh KC,Paik SW,Kim JM,Joh JW,Choi GS

    更新日期：2020-04-01 00:00:00

  • Preliminary analysis of factors influencing organ donation rates in China.

    abstract：:In recent years, the People's Republic of China has experienced advancements in organ transplant surgical techniques, growing transplant waiting lists, and stagnant organ donation rates. All of these factors have pressured China to find ways to increase brain-dead cadaveric donation rates to narrow the gap between org...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.01.166

    authors： Zhang L,Wang J,Kwauk S,Wu Q,Nielson K,Zeng F,Bai M,Wang C

    更新日期：2011-06-01 00:00:00

  • Switch to everolimus for sirolimus-induced pneumonitis in a liver transplant recipient--not all proliferation signal inhibitors are the same: a case report.

    abstract：:We report a 62-year-old female liver transplant patient who presented with sirolimus (SIR)-related pneumonitis (SIP) treated with a switch to everolimus (EVER). At 13-month follow-up, the patient is on EVER monotherapy with no recurrence of SIP. Despite common mechanisms of action, the safety profile of EVER is differ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.09.040

    authors： De Simone P,Petruccelli S,Precisi A,Carrai P,Doria R,Menichetti F,Filipponi F

    更新日期：2007-12-01 00:00:00

  • Use of quality index in the evaluation of organ procurement and transplant programs in a University Hospital.

    abstract：AIM:To evaluate organ procurement efficiency at Hospital Clinic of Barcelona (HCP), a University Hospital, in 2000 and 2003 compared with other Catalan, other Spanish, and American (US) results. METHODS:Efficacy rate of the donor procurement was calculated per million population per year (pmp/y). Efficacy rate in kidn...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.08.052

    authors： Manyalich M,Mañalich R,Boni RC,Paredes D,Vilarrodona A,Vilardell J

    更新日期：2005-11-01 00:00:00

  • Liver transplantation for biliary atresia in Taiwan: a national study.

    abstract：:A national database for orthotopic liver transplantation (OLT) among biliary atresia (BA) cases in Taiwan has not been reported. Using the National Health Insurance (NHI) database to investigate the prognostic features of patients with BA receiving OLT, we studied the prognosis of this procedure for BA. The NHI in Tai...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.07.136

    authors： Tiao MM,Yang CY,Tsai SS,Chen CL,Kuo HW

    更新日期：2008-12-01 00:00:00

  • Campath-1H (alemtuzumab) as an induction agent for the prevention of graft rejection and preservation of renal function in kidney transplant patients: Philippine 3-year follow-up.

    abstract：OBJECTIVE:The purpose of this study was to evaluate the safety and efficacy of induction with Campath-1H with low-dose cyclosporine (CsA) monotherapy using outcome measures of acute rejection episodes (ARE), chronic allograft nephropathy (CAN), graft and patient survivals, as well as malignancies and infections. MATER...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2008.07.085

    authors： Muñoz AS,Cabanayan-Casasola CB,Danguilan RA,Padua FB,Ona ET

    更新日期：2008-09-01 00:00:00

  • Worse renal transplant outcomes observed among Afro-Brazilian patients on prospective registry data of 2461 renal transplants at least 1 year follow-up.

    abstract：:We present prospective registry data of 2461 (live donor = 1753 and deceased donor = 08) renal transplants performed between 1999 and 2003. All subjects were followed for more than 1 year after transplantation and most were treated with a calcineurin inhibitor and azathioprine. Afro-Brazilian, white, and mixed patient...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.01.034

    authors： Medina-Pestana JO,Sampaio EM,Vaz ML,Pinheiro-Machado PG,Tedesco-Silva H Jr

    更新日期：2007-03-01 00:00:00

  • Stable renal transplant recipients can be safely converted from MMF to enteric-coated mycophenolate sodium tablets: Interim results of a multicenter Latin American study.

    abstract：:Enteric-coated mycophenolate sodium (EC-MPS) is designed to reduce mycophenolate acid (MPA)-related upper gastrointestinal (GI) adverse events (AEs). A multicenter, open-label, Latin American study in stable renal transplant patients is ongoing to assess the safety of the conversion from mycophenolate mofetil (MMF) to...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.transproceed.2004.07.031

    authors： Abbud-Filho M,Girón F,Hernández E,Juarez F,Liendo C,Novoa P,Toledo M,Myproms Latam Study Group.

    更新日期：2004-07-01 00:00:00

  • Drug interaction between tacrolimus and ertapenem in renal transplantation recipients.

    abstract：:To show drug interactions between tacrolimus and ertapenem, we retrospectively evaluated 13 renal transplant recipients who had been treated with ertapenem for urinary tract infections during prescription of a constant dose. The mean dose of tacrolimus to achieve desired therapeutic concentrations decreased significan...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.08.003

    authors： Bora F,Aliosmanoglu I,Kocak H,Dinckan A,Uslu HB,Gunseren F,Suleymanlar G

    更新日期：2012-12-01 00:00:00

  • Metaanalysis of statins and survival in de novo cardiac transplantation.

    abstract：BACKGROUND:The use of HMG CoA reductase inhibitors (statins) after cardiac transplantation has been suggested to decrease the incidence of severe rejection and improve survival. Individual investigations that have led to this suggestion are randomized (but not placebo-controlled) studies, including small patient number...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.transproceed.2004.05.036

    authors： Mehra MR,Raval NY

    更新日期：2004-06-01 00:00:00

  • Mortality while awaiting liver retransplantation: predictability of MELD scores.

    abstract：INTRODUCTION:Model for End-stage Liver Disease (MELD) scores at the time of listing on the transplant waiting list have been shown to accurately predict 3-month mortality in adults. There is no data assessing the accuracy of the MELD scores in predicting mortality of patients awaiting liver retransplantation. We sought...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.03.004

    authors： Watt KD,Menke T,Lyden E,McCashland TM

    更新日期：2005-06-01 00:00:00

  • Biliodigestive anastomosis in liver transplantation: review of 13 years.

    abstract：:Hepaticojejunostomy is a good alternative technique for biliary reconstruction in liver transplantation. Among 517 liver transplants performed between March 1992 and July 2005, 33 involved hepaticojejunostomy, namely, 18 men and 12 women of average age: 44.8 years. The main cause for this technique was retransplant (n...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.001

    authors： Valera-Sanchez Z,Flores-Cortes M,Romero-Vargas ME,Gómez-Bravo MA,Pareja-Ciuró F,Lopez-Bernal F,Barrera-Pulido A,Bermejo-Navas J,García-González I,Bernardos-Rodriguez A

    更新日期：2006-10-01 00:00:00

  • Effect of Immunosuppressive Therapy on Cardiovascular Risk Factor Prevalence in Kidney-Transplanted Children: Comparative Study.

    abstract：BACKGROUND:Cardiovascular disease (CVD) is the second major cause of death in kidney-transplanted children. Cardiovascular risk factors (CVRF) prevalence after transplant may increase. The effect of immunosuppressive therapy has not been fully studied in children. The objective of the study was to measure and compare C...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.02.034

    authors： García-Bello JA,Romo-Del Río EG,Mendoza-Gómez E,Camarena-Arias PA,Santos-Caballero M

    更新日期：2016-03-01 00:00:00

  • Immunosuppression Strategies in the Treatment of Hepatocellular Carcinoma in Virgen de las Nieves University Hospital.

    abstract：BACKGROUND:We describe an observational, retrospective study that included patients who underwent a liver transplantation (LT) for hepatocellular carcinoma (HCC) in our center between 2004 and 2012. METHODS:Clinical variables were recorded for donors and recipients as diagnosis and treatment, immunosuppressive therapy...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.08.020

    authors： San Miguel C,Fundora Y,Triguero J,Muffak K,Villegas T,Becerra A,Garrote D,Ferrón JA

    更新日期：2015-10-01 00:00:00

  • Excessive portal flow causes graft nonfunction in small size liver transplantation: an experimental study in pigs.

    abstract：:We investigated the effects of portocaval shunt (PCS) on excessive portal flow in producing sinusoidal microcirculatory injury in small-for-size liver transplants in pigs. The posterior segment of a whole liver (25%) was transplanted orthotopically. The pigs were divided two groups: group A, graft with PCS (n = 11), a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.01.002

    authors： Wang HS,Enomoto Y,Usuda M,Miyagi S,Asakura T,Masuoka H,Fukushima K,Aiso T,Narita T,Yamaya H,Sekiguchi S,Kawagishi N,Sato A,Ohkohchi N,Satomi S

    更新日期：2005-01-01 00:00:00

  • Facial Nerve Palsy Complicated by Masked Tuberculous Mastoiditis in a Recently Transplanted Patient.

    abstract：:Mastoiditis is a complication of the medium otitis characterized by suppuration and destruction of the mastoid cells and the pyramid petrosa; its tuberculous etiology has decreased in the last 40 years. Paralysis resulting from mastoiditis is more common in children. The incidence of mastoiditis has risen, although th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.06.007

    authors： Hernandez Fustes OJ,Rodriguez CA,Ferreira GME,Borges FZ

    更新日期：2020-11-01 00:00:00

  • Kidney transplant donor glomerular filtration rate by iohexol clearance during computerized tomographic angiography of the kidneys.

    abstract：BACKGROUND:Pre-transplantation living-donor kidney function determines remaining donor kidney function and significantly affects post-transplantation allograft function in the recipient. Few transplantation centers perform donor kidney function measurement owing to patient burden. A simplified method of glomerular filt...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.05.010

    authors： Hu SL,Igari M,Walle NL,Steffes MW,Beland MD,Collins SA,Gohh RY

    更新日期：2013-11-01 00:00:00

  • Experimental training model of pancreas transplant.

    abstract：UNLABELLED:Pancreas transplant (Ptx) is the gold standard for the treatment of type I diabetes, mainly when associated with renal failure. The number of Ptx is increasing worldwide, but in developing countries, such as Brazil, the number of centers is small and transplant surgeons need to practice the technique. METHO...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.056

    authors： David AI,Aquino CG,Guidoni LR,Moricz A,David-Neto E,Pacheco AM Jr,Szutan LA

    更新日期：2006-07-01 00:00:00

  • Factors affecting graft survival after living donor liver transplantation.

    abstract：:Living donor liver transplantation (LDLT) has been considered as an alternative option to resolve the shortage of cadaveric donor organs, despite the ethical aspects of the donor procedure. The objective of this study was to analyze the risk factors affecting graft survival in LDLT. From June 1996 to December 2002, 14...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.08.073

    authors： Lee DS,Gil WH,Lee HH,Lee KW,Lee SK,Kim SJ,Choi SH,Heo JS,Hyon WS,Kim GS,Paik SW,Koh KC,Joh JW

    更新日期：2004-10-01 00:00:00