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Hepatitis B virus, hepatitis C virus, and kidney transplant acute rejection and survival.

Abstract：

:The effect of hepatitis Bs-antigen (AgHBs) and anti-hepatitis C virus (HCV) positivity on renal transplant outcomes is still controversial. Some studies describe higher rates of acute rejection and allograft loss, and greater mortality in transplant recipients with hepatitis. We retrospectively evaluated data from 2284 allograft recipients who underwent transplantation at our hospital between July 1980 and December 2012. Statistical analysis was made using chi-square and Student t tests, Kaplan-Meier curves, and survival analysis. We identified 62 AgHBs+ patients, 99 anti-HCV+ patients, and 14 AgHBs+/anti-HCV+ patients; 2109 patients had "no hepatitis." Mean follow-up time was 7.93 years. No statistical differences were identified on allograft acute rejection rate or patient survival between groups. AgHBs+ patients had, however, an inferior allograft survival, with statistical significance. According to our study, hepatitis B has a harmful impact on allograft survival, although it does not compromise the patient survival.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Grenha V,Parada B,Ferreira C,Figueiredo A,Macário F,Alves R,Coelho H,Sepúlveda L,Freire MJ,Retroz E,Mota A

doi

10.1016/j.transproceed.2015.04.004

subject

Has Abstract

pub_date

2015-05-01 00:00:00

pages

942-5

issue

4

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)00329-2

journal_volume

47

pub_type

杂志文章

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