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The impact of obesity as determined by modified body mass index on long-term outcome after liver transplantation: Canadian single-center experience.

Abstract：

BACKGROUND:Obesity is thought to be associated with higher rates of morbidity and mortality after liver transplantation (LT); however, its actual impact is difficult to evaluate, in part because of the confounding effects of fluid accumulation on body mass index (BMI). OBJECTIVE:We sought to define the effects of conventional BMI (cBMI) and modified BMI (mBMI; calculated by multiplying the BMI by serum albumin level to compensate for fluid accumulation), on the outcome of LT recipients overall. METHODS:A cohort of 507 patients who underwent LT from April 2000 to August 2006 were analyzed. RESULTS:Pre-LT diabetes mellitus was seen somewhat more frequently in the higher mBMI group (P = .054), whereas there was no difference across cBMI categories. The recipients at extremes of cBMI (>40 kg/m(2) and <18.5 kg/m(2)) had significantly lower patient and graft survival than other groups (P = .038 and P = .010, respectively); however, no statistically significant differences were found in overall patient and graft survival across mBMI categories. There were no differences in duration of intensive care unit stay, duration of overall hospital stay, and vascular complications after LT among mBMI categories. CONCLUSIONS:Pre-LT obesity alone, when estimated by mBMI rather than by cBMI, should not be a contraindication for LT.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Tanaka T,Renner EL,Selzner N,Therapondos G,Lilly LB

doi

10.1016/j.transproceed.2012.11.009

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2288-94

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(12)01314-0

journal_volume

45

pub_type

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