The impact of obesity as determined by modified body mass index on long-term outcome after liver transplantation: Canadian single-center experience.


BACKGROUND:Obesity is thought to be associated with higher rates of morbidity and mortality after liver transplantation (LT); however, its actual impact is difficult to evaluate, in part because of the confounding effects of fluid accumulation on body mass index (BMI). OBJECTIVE:We sought to define the effects of conventional BMI (cBMI) and modified BMI (mBMI; calculated by multiplying the BMI by serum albumin level to compensate for fluid accumulation), on the outcome of LT recipients overall. METHODS:A cohort of 507 patients who underwent LT from April 2000 to August 2006 were analyzed. RESULTS:Pre-LT diabetes mellitus was seen somewhat more frequently in the higher mBMI group (P = .054), whereas there was no difference across cBMI categories. The recipients at extremes of cBMI (>40 kg/m(2) and <18.5 kg/m(2)) had significantly lower patient and graft survival than other groups (P = .038 and P = .010, respectively); however, no statistically significant differences were found in overall patient and graft survival across mBMI categories. There were no differences in duration of intensive care unit stay, duration of overall hospital stay, and vascular complications after LT among mBMI categories. CONCLUSIONS:Pre-LT obesity alone, when estimated by mBMI rather than by cBMI, should not be a contraindication for LT.


Transplant Proc


Tanaka T,Renner EL,Selzner N,Therapondos G,Lilly LB




Has Abstract


2013-07-01 00:00:00














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    abstract::Renal transplantation is the treatment of choice for end-stage renal disease. Vascular complications in renal transplantation are not uncommon and may often lead to allograft loss. The most common vascular complications are transplant renal artery stenosis, transplant renal artery thrombosis, transplant renal vein thr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dimitroulis D,Bokos J,Zavos G,Nikiteas N,Karidis NP,Katsaronis P,Kostakis A

    更新日期:2009-06-01 00:00:00

  • Hepatic artery reconstruction in living donor liver transplantation: running suture under surgical loupes by cardiovascular surgeons in 180 recipients.

    abstract:OBJECTIVES:The aim of our study was to retrospectively investigate the outcomes of hepatic artery (HA) reconstruction by cardiovascular surgeons in adult-to-adult living donor liver transplantation (A-A LDLT). METHODS:From April 2007 to April 2011, 187 recipients underwent A-A LDLT. After excluding seven ABO-incompati...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Li PC,Jeng LB,Yang HR,Lee CC,Poon KS,Chen TH,Yeh CC,Lai HC,Su WP,Peng CY,Chen YF,Ho YJ

    更新日期:2012-03-01 00:00:00

  • Decrease in serum tacrolimus level and rise in serum creatinine under late addition of cinacalcet in a renal transplant recipient with hyperparathyroidism: a case report.

    abstract::Cinacalcet is a calcimimetic drug that has been approved for treatment of secondary and tertiary hyperparathyroidism in patients with renal failure requiring renal replacement therapy. A few cases of successful treatment in renal transplant patients immunosuppressed with cyclosporine have been reported. Herein we have...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Maass E,Mueller GA,Heller T,Koziolek MJ

    更新日期:2007-12-01 00:00:00

  • Morbidity rates with reduced mycophenolate mofetil dosage: a single-center experience.

    abstract:OBJECTIVE:Mycophenolate Mofetil (MMF) is a key component of available immunosuppressant regimens for transplantation. Traditionally a dose of 2 g/d is utilized, with the incidence of side effects, most notably gastrointestinal, being well known to transplant teams. The aim of this study was to assess the incidence of s...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kaushik M,Kay MD,Bagul A,Nicholson ML

    更新日期:2006-11-01 00:00:00

  • Fluctuations of exercise capacity in patients after kidney transplantation.

    abstract:INTRODUCTION:The aim of this study was to assess changes in the exercise capacity in subjects with end-stage renal failure undergoing kidney transplantation. MATERIALS AND METHODS:The study group consisted of 16 subjects (9 males and 7 females) of mean age 43.3 +/- 11 years. The control group was composed of 7 healthy...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zakliczynski M,Spiechowicz U,Krynicka A,Trybunia D,Pyka L,Wiecek A,Zembala M

    更新日期:2009-01-01 00:00:00

  • Intracardiac erythropoietin injection reveals antiinflammatory potential and improved cardiac functions detected by Forced Swim Test.

    abstract::Systemic administration of erythropoietin (Epo) protects the myocardium from an ischemic insult and promotes beneficial remodeling. We hypothesized that intracardiac injection of Epo may exhibit cardioprotective potential with reduced systemic toxicity. Following myocardial infarction (MI), Epo was injected directly i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Furlani D,Klopsch C,Gäbel R,Ugurlucan M,Pittermann E,Klee D,Wagner K,Li W,Wang W,Ong LL,Nizze H,Titze U,Lützow K,Lendlein A,Steinhoff G,Ma N

    更新日期:2008-05-01 00:00:00

  • Massive ascites due to right heart failure after cardiac transplantation and its treatment: a case report.

    abstract::Ascites is a common clinical condition during right heart failure. In this short report we have presented a patient with massive ascites due to right heart failure after cardiac transplantation who was previously operated for Ebstein's anomaly and pulmonary stenosis as well as mitral and tricuspid valve repairs. Right...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sezgin A,Uguz E,Akay T,Aşlamaci S

    更新日期:2008-01-01 00:00:00

  • Graft-vs-Host Disease-Induced Hyperthyroidism in a Recipient of Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report.

    abstract:BACKGROUND:Hyperthyroidism after hematopoietic stem cell transplantation (HSCT) is rare, and only a few cases have been reported. What is more important, the fundamental mechanisms of hyperthyroidism after HSCT remained unclear. CASE:A 28-year-old man received an HLA haploidentical related-donor HSCT for acute myeloid...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Huang F,Liao N,Guan Y,Jin H,Ye J,Fan Z,Xuan L,Liu Q,Shi P

    更新日期:2020-11-01 00:00:00

  • Thrombomodulin administration attenuates ischemia-reperfusion injury of the remnant liver after 70% hepatectomy in rats: simulated model of small-for-size graft in living donor liver transplantation.

    abstract:BACKGROUND:Hepatic ischemia-reperfusion injury (IRI) is a serious complication affecting liver function and postoperative course after liver transplantation. Thrombomodulin (TM) has been known to have anticoagulant and anti-inflammatory activities exerting a cytoprotective effect. We evaluated the cytoprotective effect...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tanemura A,Kuriyama N,Azumi Y,Ohsawa I,Kishiwada M,Mizuno S,Usui M,Sakurai H,Tabata M,Isaji S

    更新日期:2014-05-01 00:00:00

  • Prevalence of previous hepatitis A virus infection in renal transplant patients with hepatitis C: evidence of persistent anti-hepatitis A virus immune response.

    abstract::Data concerning the prevalence of hepatitis A virus (HAV) infection among kidney transplant recipients are scarce. There is little information concerning natural immunity acquired after acute HAV infection. In most renal transplant recipients, anti-HAV antibodies are not detectable after vaccination; it is reasonable ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mariya FA,de Mello Perez R,Silva AE,Pestana JO,Ferraz ML

    更新日期:2004-06-01 00:00:00

  • Alleviating ischemia-reperfusion injury in aged rat liver by induction of heme oxygenase-1.

    abstract:BACKGROUND:Heme oxygenase-1 (HO-1), a cytoprotective protein, may be important in ameliorating hepatic ischemia-reperfusion (I/R) injury, a critical factor in the dysfunction of the aged liver after transplantation. METHODS:We used hemin to overexpress HO-1 and analyze its effects in a model of I/R in aged livers used...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wang XH,Wang K,Zhang F,Li XC,Qian XF,Cheng F,Li GQ,Fan Y

    更新日期:2004-12-01 00:00:00

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kaldas F,Farmer D,Gordon SA,McDiarmid SV,Venick R,Colangelo J,Busuttil RW

    更新日期:2007-12-01 00:00:00

  • Comparison of Sirolimus Combined With Tacrolimus and Mycophenolate Mofetil Combined With Tacrolimus in Kidney Transplantation Recipients: A Meta-Analysis.

    abstract:PURPOSE:The study was designed to compare the outcomes of sirolimus (SRL) combined with tacrolimus (TAC) and mycophenolate mofetil (MMF) combined with TAC in kidney transplantation recipients. METHODS:A literature search of PubMed, Embase, and Web of Science was performed to identify relevant studies, and the last upd...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,meta分析


    authors: Gao L,Xu F,Cheng H,Liu J

    更新日期:2018-12-01 00:00:00

  • Pericardial Effusion Associated With Sirolimus Use After Renal Transplantation: A Single-Center Case Series.

    abstract::Pericardial effusion and cardiac tamponade following renal transplantation have been recognized as a potentially serious complications associated with the use of sirolimus for immunosuppression. Our study aims to analyze the development of sirolimus-associated pericardial effusion. Patients who underwent renal transpl...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lopez-Soler RI,Patel SK,Lyubarova R,Pashkovetsky E,Wang S,Schuster D,Chandolias N,Conti D

    更新日期:2019-01-01 00:00:00

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    abstract::Advances in the surgical techniques, preservation solutions, and methods for predicting eventual long-term renal function from expanded donors will be critical in allowing precise selection criteria for kidneys for transplantation, resulting in the optimum use of a scarce and precious resource. Until other options suc...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Jordan ML,Shapiro R,Vivas CA,Scantlebury VP,Corry RJ,Randhawa P,Hakala TR,Starzl TE

    更新日期:1999-02-01 00:00:00

  • New concepts in organ transplantation.

    abstract::Major progress has been made in clinical transplantation over recent years due to close cooperation between clinical specialists and academic investigators. High success rates are evident by longer patient and graft survivals. Treatment procedures have been integrated into fixed protocols utilizing new chemical immuno...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Paczek L,Pawlowska M,Krawczyk M,Rowinski W

    更新日期:2004-06-01 00:00:00

  • Risk factors for delayed renal graft function and their impact on renal transplantation outcome.

    abstract:OBJECTIVE:The objective of this study was to evaluate the risk factors for delayed graft function (DGF) and their influence on renal graft outcome. PATIENTS AND METHODS:We reviewed 1462 consecutive renal transplantation and identified 245 patients (17.1%) with delayed graft function and 1120 patients with immediate gr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Figueiredo A,Moreira P,Parada B,Nunes P,Macário F,Bastos C,Mota A

    更新日期:2007-10-01 00:00:00

  • Living related liver transplantation. Why this option has been discarded in a pediatric liver transplant program in Chile.

    abstract::Living related living transplantation (LRLT) has opened new possibilities for planning transplantation in better conditions for children with emergency situations and chronic liver diseases. Since we began the LRLT program in 1999, we have performed 57 pediatric liver transplants, 17 (29.8%) using living related donor...

    journal_title:Transplantation proceedings

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    authors: Uribe M,Buckel E,Ferrario M,Godoy J,González G,Ceresa S,Hunter B,Cavallieri S,Berwart F,Blanco A,Smok G,Calabrán L,Herzog C,Santander MT

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  • Superoxide anion as a marker of ischemia-reperfusion injury of the transplanted kidney.

    abstract::Reactive oxygen species (ROS) are considered to be important factors involved in the pathophysiology of renal ischemia-reperfusion injury. ROS-induced alterations of proteins, carbohydrates, DNA, and lipid membranes lead to cell and organ dysfunction. Several antioxidant defense mechanisms exist to prevent or limit ox...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Masztalerz M,Włodarczyk Z,Czuczejko J,Słupski M,Kedziora J

    更新日期:2006-01-01 00:00:00

  • Posttransplant lymphoproliferative disorder in pediatric liver transplantation.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Uribe M,Hunter B,Alba A,Calabrán L,Flores L,Soto P,Herzog C

    更新日期:2009-07-01 00:00:00

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    authors: Trapani S,Morabito V,Oliveti A,Peritore D,Rizzo A,Cacciotti AR,Gaeta A,Montemurro A,Rizzato L,Nanni Costa A

    更新日期:2016-03-01 00:00:00

  • Incidence, management, and results of vascular complications after liver transplantation.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pérez-Saborido B,Pacheco-Sánchez D,Barrera-Rebollo A,Asensio-Díaz E,Pinto-Fuentes P,Sarmentero-Prieto JC,Rodríguez-Vielba P,Martínez-Díaz R,Gonzalo-Martín M,Rodríguez M,Calero-Aguilar H,Pintado-Garrido R,García-Pajares F,Anta-R

    更新日期:2011-04-01 00:00:00

  • Prostate Cancer in Renal Transplant Recipients: Diagnosis and Treatment.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Carvalho JA,Nunes P,Dinis PJ,Antunes H,Parada B,Marconi L,Moreira P,Roseiro A,Bastos C,Rolo F,Dias V,Figueiredo A

    更新日期:2017-05-01 00:00:00

  • Prophylactic use of low-dose, on-demand, intramuscular hepatitis B immunoglobulin and lamivudine after liver transplantation.

    abstract::The combination of hepatitis B immunoglobulin (HBIG) and antivirals (nucleos[t]ide analogs) has extended the applicability of orthotopic liver transplantation (OLT) for patients with hepatitis B virus (HBV)-related liver disease. However, HBIG administrations have an extremely high cost. Herein, we evaluated our resul...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Karademir S,Astarcioğlu H,Akarsu M,Ozkardesler S,Ozzeybek D,Sayiner A,Akan M,Tankurt E,Astarcioğlu I

    更新日期:2006-03-01 00:00:00

  • The effects of C-reactive protein, interleukin-6, and tumor necrosis factor-alpha in rat allograft adventitial inflammation and allograft arteriosclerosis.

    abstract::This study was designed to investigate the role of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) during allograft adventitial inflammation and arteriosclerosis. Lewis rats were used as donors and Wistar rats as recipients for the experimental groups, while both donors and ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sun H,Lu X,Wu S,Sun W

    更新日期:2009-11-01 00:00:00

  • Identifying Predictors of Outcomes in Combined Heart and Liver Transplantation.

    abstract:BACKGROUND:Combined heart and liver transplant (CHLT) is a complex procedure that is being increasingly performed. Because of the relative rarity of this procedure, graft and patient outcomes are still being assessed and risk factors for graft and patient survival are unknown. MATERIALS AND METHODS:This is a retrospec...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lee S,Matsuoka L,Cao S,Groshen S,Alexopoulos SP

    更新日期:2019-01-01 00:00:00

  • Analysis of the Eurotransplant Kidney Allocation Algorithm: How Should We Balance Utility and Equity?

    abstract:BACKGROUND:Since 2014, expected graft and recipient survival are matched by the U.S. kidney allocation system to improve organ utility. This mechanism is based on the kidney donor profile index (KDPI) and the estimated posttransplant survival score (EPTS). Here we analyzed 1. the transferability of these scores into th...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Schulte K,Klasen V,Vollmer C,Borzikowsky C,Kunzendorf U,Feldkamp T

    更新日期:2018-12-01 00:00:00

  • Mitral valve dysfunction and repair following orthotopic heart transplantation: a case report.

    abstract::Mitral valve dysfunction after orthotopic heart transplantation may cause symptoms refractory to medical therapy. In this report, we present a patient who underwent mitral annuloplasty for severe symptomatic mitral valve insufficiency 9 years after heart transplantation, and we critically appraise the literature avail...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wigfield CH,Lewis A,Parry G,Dark JH

    更新日期:2008-06-01 00:00:00

  • Immunologic tolerance: tailored antigen.

    abstract::In summary, synthetic peptides corresponding to linear sequences of HLA class I molecules can inhibit T-cell responses in vitro and in vivo. These peptides induce immunologic tolerance by binding to hsp-70 family members, causing an increase in intracellular calcium, and down-regulating the nuclear factor of activated...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Krensky AM,Clayberger C

    更新日期:1996-08-01 00:00:00

  • Cytomegalovirus disease after kidney transplantation: clues to accurate diagnosis.

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nemati E,Eizadi M,Lankarani MM,Kardavani B,Khoddami-Vishteh HR,Kalantar E,Lesan-Pezeshki M,Khedmat H,Saadat AR

    更新日期:2007-05-01 00:00:00