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Porcine Transgenic, Acellular Material as an Alternative for Human Skin.

Abstract：

:Although new therapeutic approaches for burn treatment have made progress, there is still need for efficient coverage of donor fields. Promising dressing for skin graft donor site should be biocompatible, attach easily to the wound bed, remain in place until donor site has renewed, and decrease morbidity at the site. Porcine skin may be applied as a dressing for severe burns. Therefore pig skin xenografts can be used also as donor field coverage. In the Burn Treatment Centre, we used gauze soaked in Vaseline to secure donor fields. The aim of the study was to check if transgenic porcine skin is better than standard in donor site coverage used in our center. We showed that dressing reduces pain experienced by patients. The dressing leads to a reduction of hospitalization time by an average of 8 days. The dressing is as safe as the gold standard. Securing the donor field reduces the risk of colonization of the wound in the second smear after application by 60%. The disadvantage of the dressing is the inability to absorb blood; the use of hemostatic ointments in combination with the skin of transgenic pigs should be considered in the future.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Kitala D,Klama-Baryła A,Łabuś W,Kraut M,Glik J,Kawecki M,Joszko K,Gzik-Zroska B

doi

10.1016/j.transproceed.2020.01.125

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

2218-2222

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(19)31843-3

journal_volume

52

pub_type

临床试验,杂志文章

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