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Induction therapy with basiliximab and full HLA mismatch.

Abstract：

INTRODUCTION:Induction therapy reduces rejection episodes among patients at high immunologic risk. Antithymocyte globulins appear to be superior to basiliximab in this population, despite the greater potential risk of infection and neoplasia. The aim of this study was to evaluate graft function and acute rejection episodes in 6 HLA-mismatched patients who underwent induction with basiliximab but had no other immunologic risk factors. METHODS:We analyzed retrospectively patients who were transplanted using basiliximab for induction therapy during a 4 year period, comparing patients with full HLA mismatches with those who had 5 or fewer mismatches. None of the patients had other immunological risk factors for rejection. RESULTS:We observed no significant differences between the groups concerning demographic features, cold ischemia times, and panel reactive antibodies. Graft function at 12 and 24 months was not different between both groups. Acute rejection episodes were also not different between groups. DISCUSSION:In this population of full HLA mismatches and no other immunological risk factors, induction immunosuppression therapy with basiliximab was safe in terms of graft function and acute rejection episodes.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Outerelo C,Gouveia R,Mateus A,Cruz P,Oliveira C,Ramos A

doi

10.1016/j.transproceed.2013.03.010

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

1076-8

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00313-8

journal_volume

45

pub_type

杂志文章

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