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Treatment of acute graft-vs-host disease after simultaneous pancreas-kidney transplantation: a case report.

Abstract：

:Whereas neutropenia is common after solid-organ transplantation, graft-vs-host disease is unusual, especially after simultaneous pancreas-kidney transplantation. Most cases reported in the literature give few details of treatment approach, and all were fatal. A 45-year-old man with diabetes underwent simultaneous pancreas-kidney transplantation at our center, with organs from a female donor. Two weeks postoperatively, he was readmitted with fever, malaise, and neutropenia. A bone marrow biopsy specimen demonstrated that two-thirds of the lymphocytes were of female karyotype. Graft-vs-host disease was diagnosed. Aggressive immunosuppression therapy was administered; however, the patient died. To our knowledge, this is the first case report with specific details of a treatment protocol and sequential short tandem repeat data.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Osband AJ,Laskow DA,Mann RA

doi

10.1016/j.transproceed.2010.08.058

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

3894-7

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)01299-6

journal_volume

42

pub_type

杂志文章

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