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Acute Antibody-Mediated Rejection as Cause of Late Liver Allograft Failure: A Case Report.

Abstract：

BACKGROUND:Despite now being an infrequent complication in liver transplantation (LT) recipients, acute liver failure is still associated with high mortality. CASE REPORT:Here we report a case of acute liver failure 11 months after AB0-compatible LT in a hepatitis C-positive 50-year-old male recipient caused by late antibody-mediated rejection (AMR). De novo donor-specific antibodies appeared later in a previously negative donor-recipient crossmatch, leading to a rapid deterioration of liver function. CONCLUSIONS:We highlight the importance of an accurate diagnosis and an early therapeutic intervention. The analysis of this case brings novel and generalizable insights to the differential diagnosis of acute liver failure after LT.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Vellalta G,Dopazo C,Bilbao I,Castells L,Sapisochin G,Lázaro JL,Montero Á,Salcedo MT,Caralt M,Charco R

doi

10.1016/j.transproceed.2015.10.036

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

3016-9

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)01036-2

journal_volume

47

pub_type

杂志文章

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