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Long-term endoscopic follow-up in small bowel transplant recipients: single-center series.

Abstract：

BACKGROUND:The reliability of endoscopic findings after adult intestinal transplantation on short-term follow-up has been shown. The aim of this study was to evaluate in a long-term follow-up the diagnostic value of endoscopies compared with the biopsy value. METHODS:We evaluated 52 endoscopies over a period of 2 years (2 in each patient in 2010 and 1 in each patient in 2011, plus 1 endoscopy for suspected post-transplant lymphoproliferative disease [PTLD]) on 17 recipients transplanted between the years 2000 and 2006 (more than 5 years of follow-up). RESULTS:All the 52 endoscopic findings were comparable to biopsy definitive results: only 1 case of mild enteritis and 1 case of Epstein-Barr virus (EBV) chronic infection at biopsy were not diagnosed by endoscopy. One case of rectal PTLD and 1 of EBV-related enteritis were diagnosed by use of both procedures. Specificity was 98%: we did not calculate sensitivity because no episodes of rejection were diagnosed because recipients were stable in long-term follow-up. CONCLUSIONS:Endoscopy is a reliable procedure even on a long-term follow-up after intestinal transplantation, allowing a support to biopsy for diagnosis on adult recipients, especially for EBV infections and PTLD surveillance.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Lauro A,Pinna AD,Pellegrini S,Bagni A,Zanfi C,Dazzi A,Pironi L,Di Simone MP

doi

10.1016/j.transproceed.2014.07.025

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

2325-8

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00528-4

journal_volume

46

pub_type

杂志文章

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