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Management of kidney transplantation in a factor VII-deficient patient: case report.

Abstract：

:Transplantation in patients with congenital bleeding disorders is a challenge requiring an integrated approach of various specialists. Renal transplantation, the most frequent type of solid organ transplantation, is rarely performed in individuals with congenital hemorrhagic disorders. We performed a renal transplantation in a 53-year-old man with end-stage renal disease and congenital coagulation factor VII deficiency, a rare bleeding disorder with a peculiar clinical picture requiring replacement therapy in surgical interventions. Perioperative bleeding was successfully prevented by administration of recombinant activated factor VII. Treatment schedule, administration rate, and long-term follow-up are reported in detail. Our report confirmed the feasibility and safety of recombinant activated factor VII in major surgical procedures like solid organ transplantations. Success requires evaluation of doses and therapeutic schedules as well as a multidisciplinary approach.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Lapecorella M,Napolitano M,Lucchesi A,Pisani F,Clemente K,Rizza V,Famulari A,Aloisio L,Bernardi F,Pinotti M,Ferraresi P,Di Cocco P

doi

10.1016/j.transproceed.2012.07.001

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

2033-5

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(12)00697-5

journal_volume

44

pub_type

杂志文章

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