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Long-term results after simultaneous pancreas-kidney transplantation using donors aged 45 years or older.

Abstract：

UNLABELLED:With the shortage of organ donors, there is a critical need to use all available pancreas grafts for transplantation. METHODS:From June 1994 to December 2006 we performed 340 pancreas transplantations (317 simultaneous pancreas-kidney 5 pancreas only, 18 pancreas after kidney) including 69 (20%) transplantations from donors aged 45 years or older. Pancreas grafts from older donors were analyzed for graft and patient survival as well as surgical complications, compared with results from younger donors. RESULTS:Recipient characteristics were comparable in both groups. The older donor group mean age was 47.8 years (+/-2.1) versus 27.9 years (+/-10.3) for the younger group. Cumulative patient survival was 96% versus 98% after 1, 82% versus 91% after 5 and 82% versus 88% after 10 years with 1-5- and 10-year kidney graft survivals of 82%, 72%, 57% versus 93%, 83%, 73%, respectively. Pancreas transplant survival after 1, 5, and 10 years were 69%, 60%, 45% in older and 88%, 76%, and 72% in younger donor cohorts. There were 14 (20%) cases of venous thrombosis in the older group and 25 (9%) in the younger group (P = .012). CONCLUSION:Our results demonstrated that utilization of pancreas grafts from donors over 45 years resulted in acceptable outcomes after simultaneous pancreas-kidney transplant and could expand the donor pool. Among the older donor group, patient survival was slightly lower than the younger group, whereas pancreas graft function was significantly inferior (P < .01). Since venous thrombosis was the main reason for pancreas graft loss in older group, anticoagulation is essential.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Schenker P,Wunsch A,Ertas N,Schaeffer M,Rump LC,Viebahn R,Vonend O

doi

10.1016/j.transproceed.2008.03.078

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

923-6

issue

4

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(08)00296-0

journal_volume

40

pub_type

杂志文章

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