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l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits.

Abstract：

:We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-l-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. The effects of LARG on hepatic injury were evaluated before and after I/R. The warm hepatic I/R procedure produced profound acute liver injury, as indicated by elevated values of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH), as well as a high apoptotic cell count. All changes were attenuated by treatment with LARG before the hepatic I/R procedure. These results suggested that LARG produced protective effects on hepatic I/R lesions. This protective effect of LARG was probably associated with blocking generation of superoxide anions during the hepatic I/R procedure.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Taha MO,Simões MJ,Haddad MA,Capelato RC,Budny N,Matsumoto AH,Soares PC,Santos WM,Armeato GD,Araki CM,Gomes JS,Magalhães KG,Tersariol IL,Monteiro HP,Oliveira-Júnior IS,Jurkiewicz A,Caricati-Neto A

doi

10.1016/j.transproceed.2009.02.050

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

816-9

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)00188-2

journal_volume

41

pub_type

杂志文章

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