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Liver transplantation in patients with hepatocellular carcinoma: one center's experience.

Abstract：

:Hepatocellular carcinoma (HCC), which worldwide is the fifth most common malignancy in men and the ninth most common malignancy in women, accounts for 6% of all malignant lesions. We evaluated our results of liver transplantation for patients with HCC. Between January 2004 and April 2007, 31 patients (5 females, 26 males; age range, 1.1-65 years) with preoperatively or incidentally diagnosed HCC underwent orthotopic liver transplantation (OLT) at our center. Eleven grafts were from deceased donors, and 20 from living-related donors. Inclusion criteria were no invasion of a major vascular structure and no evidence of extrahepatic disease. In 17 patients, tumors exceeded the Milan criteria. According to the tumor-node-metastasis staging system, 6 patients had stage 1, 8 had stage II, 2 had stage III, and 15 had stage 4A carcinoma. Three complications occurred in 31 patients: hepatic arterial thrombosis in 1 patient and biliary leakage in 2. At a mean follow-up of 24.3 +/- 12.5 months, 29 patients are well with excellent graft function. Two patients died at 23 and 17 months after OLT respectively. The longest graft survival is 43 months. There have been 4 tumor recurrences, namely, at 4, 26, 24, and 29 months after OLT, respectively. Patient and disease-free survival rates are 93.5% and 90%, respectively. In conclusion, OLT provided long-term disease-free survival for patients with HCC, even those with locally advanced tumors who had no effective alternative treatment than transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Karakayali H,Sevmis S,Moray G,Yilmaz U,Ozcay F,Savas NA,Arslan G,Haberal M

doi

10.1016/j.transproceed.2007.11.006

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

213-8

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)01355-3

journal_volume

40

pub_type

杂志文章

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