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Value of Intravoxel Incoherent Motion for Hepatocellular Carcinoma Grading.

Abstract：

BACKGROUND:To evaluate the diagnostic accuracy of intravoxel incoherent motion (IVIM) parameters in estimation of hepatocellular carcinoma (HCC) grading. MATERIALS AND METHODS:Twenty-nine patients with histopathologically diagnosed as 42 HCC at explant were included in this retrospective study. All patients were examined by 1.5T magnetic resonance imaging with the use of 4-channel phased array body coil. In addition to routine pre- and postcontrast sequences, IVIM (16 different b factors varying from 0 to 1300 s/mm2) and conventional diffusion-weighted imaging (3 different b factors of 50, 400, 800 s/mm2) were obtained with single-shot echo planar spin echo sequence. Apparent diffusion coefficient (ADC) and IVIM parameters including mean D (true diffusion coefficient), D* (pseudo-diffusion coefficient associated with blood flow), and f (perfusion fraction) values were calculated. Histopathologically, HCC was classified as low (grade 1, 2) and high (grade 3, 4) grade in accordance with the Edmondson-Steiner score. Quantitatively, ADC, D, D*, and f values were compared between the low- and high-grade groups by Student t test. The relationship between the parameters and histologic grade was analyzed using the Spearman's correlation test. To evaluate the diagnostic performance of the parameters, receiver operating characteristic analysis was performed. RESULTS:High-grade HCCs had significantly lower ADC and D values than low grade groups (P = .005 and P = .026, retrospectively); ADC and D values were inversely correlated with tumor grade (r = -0.519, P = .011, r = -0.510, P = .026, respectively). High-grade HCCs had significantly higher f values when compared with the low-grade group (P = .005). The f values were positively correlated with tumor grade (r = 0.548, P = .007). The best discriminative parameter was f value. Cut-off value of 32% of f values showed sensitivity of 75.6% and a specificity of 73.5%. CONCLUSION:ADC values and IVIM parameters such as f values appear to reflect the grade of HCCs.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sokmen BK,Sabet S,Oz A,Server S,Namal E,Dayangac M,Dogusoy GB,Tokat Y,Inan N

doi

10.1016/j.transproceed.2019.02.027

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

1861-1866

issue

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30999-0

journal_volume

pub_type

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Value of Intravoxel Incoherent Motion for Hepatocellular Carcinoma Grading.