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IL-6 determination in serum of kidney graft recipients by a new bedside test: its diagnostic relevance.

Abstract：

:Interleukin-6 (IL-6) has diagnostic importance as one of the earliest indicators of inflammation, tissue damage, hypoxia, or infection. In contrast to the time-consuming immunoassays actually used in many laboratories, results of a new IL-6 bedside test, which is interpreted visually or photometrically, are available at 20 minutes. The photometric measurement using a stored standard curve allowed differentiation of five ranges: <50, 50-100, >100-200, >200-500, and >500-1000 pg/mL. The aim of our study was to evaluate the diagnostic relevance of this new IL-6 bedside test in four well-defined, noninfectious and infectious events after kidney transplantation. In a retrospective study the IL-6 serum levels were measured in a total of 269 serum samples from 27 renal graft recipients. Analysis of all data clearly showed that the majority of elevated IL-6 levels occurred in connection with bacterial infections. Viral infections did not result in an increase of IL-6 >50 pg/mL. Thus, from a clinical point of view this new bedside test can be recommended.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Kaden J

doi

10.1016/j.transproceed.2006.12.015

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

511-3

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)01562-4

journal_volume

39

pub_type

杂志文章

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