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Galectin-1 in stable liver transplant recipients.

Abstract：

INTRODUCTION:The achievement of a state of tolerance and minimization of the immunosuppressive load form part of the "Holy Grail" in solid organ transplantation. Galectin-1 recently has been described to be involved in the maintenance of a tolerant environment, but there is no evidence of its role in human liver transplantation. The aim of our study was to measure the serum levels of galectin-1 in stable liver transplant recipients. METHODS:Serum levels of galectin-1 were determined in 30 stable liver transplant recipients who had been free of rejection episodes for at least 8 years. Fifteen patients with an acute rejection episode and 34 healthy subjects were used as the control group. RESULTS:The concentrations of galectin-1 were significantly higher in stable liver transplant recipients compared with healthy subjects and with the acute rejection group. CONCLUSIONS:These preliminary results indicate that galectin-1 is upregulated in stable liver transplant recipients. Thus, our results extend the recent findings that galectin-1 may play an immune-suppressive role in liver transplantation. It remains to be established whether it might help to induce tolerance in liver transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

García MJ,Jurado F,San Segundo D,López-Hoyos M,Iruzubieta P,Llerena S,Casafont F,Arias M,Puente Á,Crespo J,Fábrega E

doi

10.1016/j.transproceed.2014.12.001

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

93-6

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)01283-4

journal_volume

47

pub_type

杂志文章

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