The importance of clinical parameters when differentiating cholestatic hepatitis C virus from allograft rejection.


BACKGROUND:The exact cause and appropriate treatment for cholestasis following liver transplantation in recipients with hepatitis C virus recurrence (RHCV) are difficult to determine. Our objective was to determine the diagnostic accuracy of clinical and histological parameters in liver transplant recipients with RHCV and concurrent cholestasis. METHODS:A retrospective analysis from June 1996 to May 2003 was performed on adult liver transplant (OLT) recipients with hepatitis C virus. Patients with cholestasis (bilirubin >5 mg/dL, 6 months after OLT) were selected. Demographics, etiology, immune suppression, clinical and histologic outcomes, and virologic features were evaluated. Patients were divided into two groups based on clinical and histological criteria: (1) patients with parameters suggestive of cholestatic HCV; and (2) patients with parameters consistent with acute cellular rejection. RESULTS:Thirty-seven patients met study criteria (20 males). The average age was 54 years (range = 14-72), and time from transplant to jaundice was 769 days (range = 48-2981). The groups were comparable regarding HCV viral load, age, gender, time from transplant, and United Network of Organ Sharing status at time of transplant. Retransplantation was performed in two patients in group 1, neither of whom survived, and in three patients in group 2, all of whom survived. Clinical parameters correlated well with diagnosis of cholestasis (r = 0.85, P < .001) whereas histological evaluation did not (r = 0.11, P = .53). Mortality in group 1 was 78% (7 of 9) vs. 50% (13 of 26) in group 2. Median duration of survival following liver transplantation in group 1 was 132 days versus 435 days in group 2. CONCLUSION:Clinical diagnosis parameters for RHCV with cholestasis appear more accurate than histology parameters and should be the primary consideration in directing therapy. Despite timely diagnosis, cholestatic RHCV LTx recipients have a poor prognosis.


Transplant Proc


Neff GW,Shire N,Ruiz P,O'Brien C,Garcia M,Dela Garza J,Rudich SR,Reddy KR




Has Abstract


2005-12-01 00:00:00














  • Rescue of Discarded Grafts for Liver Transplantation by Ex Vivo Subnormothermic and Normothermic Oxygenated Machine Perfusion: First Experience in Spain.

    abstract:BACKGROUND:Ex vivo machine perfusion (MP) has been reported as a possibly method to rescue discarded organs. The main aim of this study was to report an initial experience in Spain using MP for the rescue of severely marginal discarded liver grafts, and to, secondarily, define markers of viability to test the potential...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ciria R,Ayllon-Teran MD,González-Rubio S,Gómez-Luque I,Ferrín G,Moreno A,Sánchez-Frías M,Alconchel F,Herrera C,Martín V,Sánchez-Hidalgo JM,Arjona-Sánchez Á,Okuda Y,Cabrera I,Benavente B,Rodriguez MJ,Jurado-Martínez I,Du

    更新日期:2019-01-01 00:00:00

  • Abnormal diurnal rhythm of urine output following renal transplantation: the impact of blood pressure and diuretics.

    abstract:BACKGROUND:Nocturnal polyuria is the excretion at night of an excessive volume of urine. A major problem following renal transplantation is an abnormal diurnal rhythmicity in urine output. The purpose of this study was to elucidate the prevalence of nocturnal polyuria among renal transplant recipients in the early peri...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Alstrup K,Graugaard-Jensen C,Rittig S,Jørgensen KA

    更新日期:2010-11-01 00:00:00

  • Hypertension after heart transplantation: predictive factors and number and classes of drugs for its management.

    abstract:BACKGROUND:This study was performed to determine the factors that cause arterial hypertension after heart transplantation (HT) and the drugs used in its management. MATERIALS AND METHODS:We studied 247 consecutive patients who had undergone HT between 2000 and 2006 and who survived for at least 6 months. We excluded p...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sánchez Lázaro IJ,Almenar Bonet L,Martínez-Dolz L,Moro López J,Ramón-Llín JA,Pérez OC,Soriano JR,Fuentes FB,Manchón JN,Sánchez Gómez JM,Sanz AS

    更新日期:2008-11-01 00:00:00

  • Hepatocellular carcinoma downstaging in liver transplantation.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is the leading malignant tumor in Taiwan. The majority of HCC patients are diagnosed in late stages and therefore in eligible for potentially curative treatments. Locoregional therapy has been advocated as an effective treatment for patients with advanced HCCs. PURPOSE:The aim...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Yu CY,Ou HY,Huang TL,Chen TY,Tsang LL,Chen CL,Cheng YF

    更新日期:2012-03-01 00:00:00

  • Risk Taking and Decision Making in Kidney Paired Donation: A Qualitative Study by Semistructured Interviews.

    abstract:INTRODUCTION:Despite excellent outcomes of kidney paired donation (KPD), little is known about how a patient's frame (apply cognitive bias) or weight (attribute value) and concerns relating to risk, justice, and equity affect his or her decision-making process. MATERIALS AND METHODS:A pilot study consisting of 3 KPD t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Baines LS,Dulku H,Jindal RM,Papalois V

    更新日期:2018-06-01 00:00:00

  • Early hepatic artery thrombosis after liver transplantation: diagnosis and treatment.

    abstract:BACKGROUND:Hepatic artery thrombosis (HAT) occurs in 3% to 9% of all liver transplantations with acute graft failure as a possible sequel. METHODS:Eleven episodes of HAT were identified among 256 orthotropic liver transplantations (whole, LDCT, split) performed on 253 patients between April 1993 and July 2006. HAT was...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Nikeghbalian S,Kazemi K,Davari HR,Salahi H,Bahador A,Jalaeian H,Khosravi MB,Ghaffari S,Lahsaee M,Alizadeh M,Rasekhi AR,Nejatollahi SM,Malek-Hosseini SA

    更新日期:2007-05-01 00:00:00

  • Transplantation in Congenital Heart Disease: A Challenge.

    abstract:BACKGROUND:Heart failure is the leading cause of death in grown-up congenital heart disease patients (GUCH). Although heart transplantation (OHT) remains the gold standard in end-stage heart failure, the ratio of GUCH patients undergoing this procedure remains low. OBJECTIVE:Describe the cohort of GUCH patients underg...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Palomo-López N,Escalona-Rodríguez S,Martín-Villén L,Herruzo-Avilés Á,Hinojosa-Pérez R,Escoresca-Ortega A,Porras-López M,Corcia-Palomo Y,Adsuar-Gómez A

    更新日期:2020-03-01 00:00:00

  • Extracorporeal shock wave lithotripsy of impacted radiolucent stone at the right pyeloureteric junction and oral dissolution therapy in a patient with transplanted liver: a case report.

    abstract::Extracorporeal shock wave lithotripsy (ESWL) is a safe, effective method to treat urinary lithiasis. The success rate in ESWL depends on stone location, size, number, and fragility as well as calceal anatomy and patency of the urinary tract. An association of calcineurin inhibitors and uric acid urolithiasis has been ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mokos I,Pasini J,Hrstić I,Stern-Padovan R,Cacic Z,Knezevic N

    更新日期:2007-12-01 00:00:00

  • Kidney exchange programs: attitudes of transplant team members toward living donation and kidney exchanges.

    abstract:INTRODUCTION:Several living donor kidney exchange programs (LDKEPs) have been established throughout the world; however, none have yet achieved the perceived substantial potential for increasing the number of living donor kidney transplants. Over the past 2 years, the Ohio Solid Organ Transplant Consortium (OSOTC) has ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Woodle ES,Bohnengel A,Boardman R,Downing K,Ohio Solid Organ Transplant Consortium Kidney Committee.

    更新日期:2005-03-01 00:00:00

  • Liver ischemic preconditioning: a new strategy for the prevention of ischemia-reperfusion injury.

    abstract::Ischemic preconditioning renders the liver more tolerant to ischemia-reperfusion injury in warm and cold ischemia-reperfusion models. In general, the application of a 5 to 10-minute period of ischemia followed by 10 minutes of reperfusion confers early effective protection to the liver. Mechanisms responsible for this...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Peralta C,Serafin A,Fernández-Zabalegui L,Wu ZY,Roselló-Catafau J

    更新日期:2003-08-01 00:00:00

  • Risk factors for the development of new-onset diabetes mellitus in a living related renal transplant program.

    abstract::New-onset diabetes mellitus is associated with considerable morbidity after transplantation. We evaluated 78 living related renal transplant recipients due to all causes except diabetic nephropathy a waiting a living related renal transplantation. We evaluated demographic characteristics, pretransplant glycemic profil...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Bora GS,Guleria S,Reddy VS,Tandon N,Gupta N,Gupta S,Bhowmik D

    更新日期:2010-12-01 00:00:00

  • Early graft dysfunction after liver transplantation.

    abstract::Liver transplantation has become the treatment of choice for fulminant hepatic failure and end-stage liver diseases. Several factors have been described to be predictors of graft function. Since early graft dysfunction dramatically influences graft and patient outcomes after liver transplantation, prevention of this e...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Briceño J,Ciria R

    更新日期:2010-03-01 00:00:00

  • Mammalian target of rapamycin and autosomal dominant polycystic kidney disease.

    abstract::Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive development of innumerable cysts in both kidneys, which distort the normal kidney architecture, leading to a loss of renal function that may necessitate renal replacement therapy and/or kidney transplantation. In experimental anim...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wüthrich RP,Serra AL

    更新日期:2009-07-01 00:00:00

  • Once daily tacrolimus formulation: monitoring of plasma levels, graft function, and cardiovascular risk factors.

    abstract:BACKGROUND:Advagraf, an extended release formulation of tacrolimus, is administered once daily during the morning fast. Tacrolimus can be safely converted from the twice daily formulation (Prograf) to the same dose (1 mg:1 mg) of once daily dosing tacrolimus (m-Tac). The adverse effects of tacrolimus play important rol...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Meçule A,Poli L,Nofroni I,Bachetoni A,Tinti F,Umbro I,Barile M,Berloco PB,Mitterhofer AP

    更新日期:2010-05-01 00:00:00

  • Cutaneous infection with rapidly-growing mycobacterial infection following heart transplant: a case report and review of the literature.

    abstract::Nontuberculous mycobacteria are ubiquitous and infrequently cause disease in humans, most commonly in immunocompromised hosts. One type of nontuberculous mycobacteria is Mycobacterium abscessus. This rapidly growing mycobacterium is a soil or water saprophyte. It was previously classified as a subspecies of Mycobacter...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Freudenberger RS,Simafranca SM

    更新日期:2006-06-01 00:00:00

  • Impact of the conversion of the immunosuppressive regimen from prograf to advagraf or to sirolimus in long-term stable liver transplant recipients: indications, safety, and outcome.

    abstract:BACKGROUND:Compliance problems have arisen due to the twice a day administration of calcineurin inhibitors (CNI). We examined the safety, indications, and efficacy in terms of graft and patient survivals after conversion from tacrolimus to sirolimus or advagraf. PATIENTS AND METHODS:Between January 2006 and December 2...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Perrakis A,Schwarz K,Yedibela S,Croner RS,Hohenberger W,Müller V

    更新日期:2011-12-01 00:00:00

  • Role of I-J-subregion gene products in the regulation of macrophage-T-Lymphocyte interaction.

    abstract::Pretreatment of splenic macrophages with anti-Ia serum specific for the various known I subregions and complement deleted the macrophages required for an in vitro antibody response to burro erythrocytes. Antibodies directed at the gene products of the I-J subregion, however, were unique in that they did not require th...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Niederhuber JE,Allen PM,Mayo L

    更新日期:1979-03-01 00:00:00

  • The new method of time-lag ligation for portosystemic shunt using coronary artery bypass graft occluder for adult living donor liver transplantation.

    abstract::We performed a living donor liver transplantation (LDLT) for a 57-year-old man who had end-stage liver failure with portal hypertension and an inferior mesenteric vein-left testicular vein (IMV-LTV) shunt. At operation, we did not clamp the shunt but encircled it with a coronary artery bypass graft (CABG) occluder (Su...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kokai H,Sato Y,Yamamoto S,Oya H,Nakatsuka H,Kobayashi T,Watanabe T,Takizawa K,Hatakeyama K

    更新日期:2009-12-01 00:00:00

  • The effects of ACE inhibition on serum angiotensin II concentration following cardiac transplantation.

    abstract:AIMS:ANGII mediates vascular neointimal formation through smooth muscle cell stimulation and enhanced production of growth factors leading to increased arterial medial layer thickness, which is a characteristic of transplant arteriosclerosis. ACE inhibition is known to be of benefit to patients with cardiovascular risk...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Fildes JE,Walker AH,Keevil B,Hutchinson IV,Leonard CT,Yonan N

    更新日期:2005-12-01 00:00:00

  • Critical progressive small-graft injury caused by intrasinusoidal pressure elevation following living donor liver transplantation.

    abstract::In adult-to-adult living liver transplantation, small-for-size graft syndrome sometimes occurs. The relationship between the hemodynamic changes and histologic findings has not been studied in patients with failure of small-for-size grafts. We analyzed the relationship between the postoperative hemodynamic changes and...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sugimoto H,Kaneko T,Hirota M,Nagasaka T,Kobayashi T,Inoue S,Takeda S,Kiuchi T,Nakao A

    更新日期:2004-11-01 00:00:00

  • Analysis of Model for End-Stage Liver Disease (MELD) score in a liver transplantation waiting list.

    abstract:BACKGROUND:The Model for End-Stage Liver Disease (MELD) was introduced in 1999 to quantify the 3-month prognosis of cirrhotic patients after a transjugular intrahepatic portosystemic shunt (TIPS). Because of the imbalance between organ donors and patients on the waiting list, the MELD was adopted by the United States i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ferraz-Neto BH,Hidalgo R,Thomé T,Melo VA Jr,Lobue A,Zurstrassen MP,Moraes JM Jr,Meira-Filho SP,Rezende MB,Fonseca LE,Pandullo FL,Soeiro FS,Afonso RC

    更新日期:2007-10-01 00:00:00

  • Depression and quality of life in terms of personal resources in heart transplant recipients.

    abstract:BACKGROUND:Heart transplantation is the first option for treatment of heart failure engendering increased survival and quality of life among recipients. However, this surgical intervention causes many psychological problems such as depression and anxiety. Protective factors and personal recourses are significant forces...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ruzyczka EW,Milaniak I,Przybyłowski P,Wierzbicki K,Siwińska J,Hubner FK,Sadowski J

    更新日期:2011-10-01 00:00:00

  • Second annual analysis of the collaborative islet transplant registry.

    abstract::In September 2001, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) founded the Collaborative Islet Transplant Registry (CITR). Each year, CITR produces a complete set of analyses available to the public. In its second year, CITR represents the efforts of 19 North American islet transplant ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究


    authors: Close N,Alejandro R,Hering B,Appel M,CITR Investigators.

    更新日期:2007-01-01 00:00:00

  • The impact of obesity as determined by modified body mass index on long-term outcome after liver transplantation: Canadian single-center experience.

    abstract:BACKGROUND:Obesity is thought to be associated with higher rates of morbidity and mortality after liver transplantation (LT); however, its actual impact is difficult to evaluate, in part because of the confounding effects of fluid accumulation on body mass index (BMI). OBJECTIVE:We sought to define the effects of conv...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tanaka T,Renner EL,Selzner N,Therapondos G,Lilly LB

    更新日期:2013-07-01 00:00:00

  • Intracardiac erythropoietin injection reveals antiinflammatory potential and improved cardiac functions detected by Forced Swim Test.

    abstract::Systemic administration of erythropoietin (Epo) protects the myocardium from an ischemic insult and promotes beneficial remodeling. We hypothesized that intracardiac injection of Epo may exhibit cardioprotective potential with reduced systemic toxicity. Following myocardial infarction (MI), Epo was injected directly i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Furlani D,Klopsch C,Gäbel R,Ugurlucan M,Pittermann E,Klee D,Wagner K,Li W,Wang W,Ong LL,Nizze H,Titze U,Lützow K,Lendlein A,Steinhoff G,Ma N

    更新日期:2008-05-01 00:00:00

  • Results and complications after living related kidney transplantation in Hungary: 30 years' experience.

    abstract::The number of patients suffering from kidney disorders is increasing the need for kidney transplantation. Kidneys originating from living donors (LD) show substantially better results than those originating from cadaveric donors (CD). We performed 3000 kidney transplantations between November 1973 and December 2007, i...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dallos G,Hídvégi M,Kósa G,Kóbori L,Alföldy F,Perner F,Járay J

    更新日期:2010-07-01 00:00:00

  • Effect of active airway warming on body core temperature during adult liver transplantation.

    abstract:INTRODUCTION:Active inspired gas humidification (AH) preserves body heat and maintains normothermia intraoperatively. However, it is unclear whether AH shows comparable influences during liver transplantation (OLT), which may be affected by both large internal heat loss and external heat supply. Thus, the aim of this s...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Han SB,Gwak MS,Choi SJ,Kim MH,Ko JS,Kim GS,Joo HS

    更新日期:2013-01-01 00:00:00

  • A necessary step toward kidney donor safety: the transition from locking polymer clips to transfixion techniques in laparoscopic donor nephrectomy.

    abstract::Donor safety is of paramount importance in addressing end-stage renal failure through living kidney transplantation. The United States Food and Drug Administration (FDA) issued a Class II recall on the use of Hem-o-lok (Teleflex, Limerick, Pennsylvania, United States) polymer clips on the renal artery in laparoscopic ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Goh YS,Cheong PS,Lata R,Goh A,Vathsala A,Li MK,Tiong HY

    更新日期:2014-01-01 00:00:00

  • Progress in Desensitization of the Highly HLA Sensitized Patient.

    abstract::The presence of HLA antibodies remains a significant and often impenetrable barrier to kidney transplantation, leading to increased morbidity and mortality for patients remaining on long-term dialysis. In recent years, a number of new approaches have been developed to overcome these barriers. Intravenous immunoglobuli...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Jordan SC,Choi J,Kahwaji J,Vo A

    更新日期:2016-04-01 00:00:00

  • Low graft function and ongoing hyperparathyroidism are closely related to post-transplantation osteoporosis.

    abstract:INTRODUCTION:Renal transplantation (RT) is the gold standard therapy for chronic renal failure. Immunosuppressive drug choice, malnutrition, adynamic bone disease and hyperparathyroidism are important factors impacting the development of posttransplant osteoporosis. Body composition analysis with bioimpedance devices (...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tutal E,Uyar ME,Colak T,Bal Z,Demirci BG,Bozkurt T,Sezer S,Acar FN

    更新日期:2013-05-01 00:00:00