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Evaluation of the efficacy and safety of the conversion from a calcineurin inhibitor to an everolimus-based therapy in maintenance renal transplant patients.

Abstract：

:Everolimus has recently been introduced into clinical practice with promising perspectives due to its efficacy, lack of nephrotoxicity, and antitumor effects. Experience in clinical trials associated with low-dose cyclosporine showed good results, but there is almost no experience in calcineurin inhibitor (CNI) elimination learning it as the primary immunosuppressant. We describe our experience in a series of 78 stable renal transplant patients who were switched to Everolimus with complete and quick elimination of the CNI: the procedure of conversion, pharmacokinetic results after conversion, evolution of renal parameters (renal function, proteinuria, and others), and safety data (acute rejection and adverse events). An initial dose of 3 mg/d was adequate to obtain the recommended trough levels between 5 and 10 ng/mL. Our results demonstrated that conversion to Everolimus was a simple, safe procedure that must be considered in patients CNI toxicity, especially those with malignant neoplasms and progressive deterioration of renal function due to chronic allograft nephropathy.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sánchez Fructuoso A,Ruiz San Millán JC,Calvo N,Rodrigo E,Moreno MA,Cotorruelo J,Conesa J,Gómez-Alamillo C,Arias M,Barrientos A

doi

10.1016/j.transproceed.2007.06.030

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

2148-50

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)00747-6

journal_volume

39

pub_type

杂志文章

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