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Haploidentical stem cell transplantation for acute leukemia patients who experienced early relapse within one year after the first transplantation.

Abstract：

:To assess the safety and efficacy of allogeneic stem cell transplantation from haploidentical related donors (haplo-SCT) as 2nd transplantation for patients with early relapsed disease, we retrospectively evaluated 7 consecutive patients (median age, 42 years; range, 29-63 years) who experienced relapse within 1 year of the 1st transplantation and received haplo-SCT as a 2nd transplantation. Among the 7 patients who received haplo-SCT, 2 who were in morphologically complete remission (CR) at transplantation were conditioned with a reduced-intensity regimen, and the 5 non-CR patients were conditioned with a myeloablative regimen. Both conditioning regimens included antithymocyte globulin. Graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus and methylprednisolone. Sustained neutrophil engraftment was achieved in all 7 patients. One patient developed severe acute GVHD. Notably, only 1 patient experienced relapse, and each patient achieved longer CR duration than after the 1st transplantation. Three of the 7 patients died from treatment-related causes: acute GVHD, post-transplantation lymphoproliferative disorder, and bacterial pneumonia. At the time of analysis, the 2-year overall survival rate of these 7 patients was 42.9%. This suggests that use of haploidentical related donors is a viable alternative for 2nd transplantation and should be confirmed in larger cohorts.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Shimizu H,Hatsumi N,Takada S,Sakura T

doi

10.1016/j.transproceed.2014.04.011

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

3611-5

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00484-9

journal_volume

46

pub_type

杂志文章

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