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Factors affecting graft survival after living donor liver transplantation.

Abstract：

:Living donor liver transplantation (LDLT) has been considered as an alternative option to resolve the shortage of cadaveric donor organs, despite the ethical aspects of the donor procedure. The objective of this study was to analyze the risk factors affecting graft survival in LDLT. From June 1996 to December 2002, 141 patients who underwent LDLT were retrospectively analyzed. Graft survival rates were 82.5%, 80%, 77.3%, and 77.3% at 6 months, 1 year, 3 years, and 5 years, respectively. The factors influencing graft survival in univariate analysis were graft-to-recipient body weight ratio (GRWR) less than 0.8% (P = .0009), intraoperative transfusion of more than six packed RBC units in addition to the use of cell saver amounts (P = .0001), left lobe grafts in adults causing small-for-size situations (P = .0135), and donor age (P = .0472). The multivariate analysis demonstrated that GRWR less than 0.8% (P = .002) and intraoperative transfusion of more than six packed RBC units (P = .014) were independent factors that decreased graft survival rates. The graft selection of greater than 0.8% of GRWR and reduction of intraoperative RBC transfusion improve graft survival.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Lee DS,Gil WH,Lee HH,Lee KW,Lee SK,Kim SJ,Choi SH,Heo JS,Hyon WS,Kim GS,Paik SW,Koh KC,Joh JW

doi

10.1016/j.transproceed.2004.08.073

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

2255-6

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)00943-1

journal_volume

36

pub_type

杂志文章

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