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MELD score and albumin replacement are related to higher costs during management of patients with refractory ascites.

Abstract：

BACKGROUND:Ascites is the most common complication of cirrhosis and indicates that the disease is at an advanced stage. In cirrhotic patients with refractory ascites, treatment is based on repeat paracentesis. The objective of this study is to evaluate the cost of paracentesis in cirrhotic patients and to determine the factors related to this cost. METHODS:This prospective study included all patients with cirrhosis who underwent paracentesis between March 2012 and March 2013 at the Outpatient Service of the Liver Transplantation Unit, Clinical Hospital, University of São Paulo School of Medicine. Microcost analysis was performed with individual tabbed data regarding the consumption of albumin and containers for ascites. The remaining cost components were drugs, materials used during the procedure, and human resources. Statistical analysis was performed using SPSS version 20. RESULTS:We conducted a total of 881 paracentesis procedures in a group of 155 patients that included 60.5% men and 39.5% women with a mean age of 57 years (range 20 to 80 years). Patients underwent an average of 5.3 paracentesis procedures per year (range 1 to 32). The total cost of all procedures was $193,126.60 and the most costly component was albumin ($87,162.10). The average cost per procedure was $219.50. The most frequent liver disease diagnoses were hepatitis C (24%) and alcoholic cirrhosis (24%). The majority of patients were on the liver transplant list (54.2%). Factors associated with higher costs in the period were a Model for End-Stage Liver Disease score higher than 24 (P = .001) and patients on the transplant waiting list (P = .042). CONCLUSIONS:Paracentesis in cirrhotic patients is a high-cost procedure in health care. The main factors related to cost are the volume of fluid drained due to the need for albumin replacement and the severity of liver disease that is related to the frequency of paracentesis.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Borges de Santana V,Bertocco de Paiva Haddad L,Morgado Conte T,Cortez Rizzon A,Miranda Barbosa V,Shield W 3rd,Andraus W,Augusto Carneiro D'Albuquerque L

doi

10.1016/j.transproceed.2014.05.017

subject

Has Abstract

pub_date

2014-07-01 00:00:00

pages

1760-3

issue

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00365-0

journal_volume

pub_type

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MELD score and albumin replacement are related to higher costs during management of patients with refractory ascites.