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Effect of Gender Differences on Transplant Kidney Function.

Abstract：

BACKGROUND:Transplant kidney function is thought to be affected by sex differences, such as physical conditions including muscle volume, sex hormones, immune responses, and so forth. We examined the effect of sex differences on transplant kidney function. METHODS:The subjects were selected from kidney transplant recipients, who received kidney transplantation on our hospital between January 2000 and August 2015. Cadaveric donors and parent-child pairs with an age difference were excluded, then we included 47 recipients whose sex was different from the sex of the donor. We compared transplant kidney function between male donors and female recipients group (M→F, n = 20) and female donors and male recipients group (F→M, n = 27). RESULTS:Nadir creatinine value was higher in the F→M group than in the M→F group (1.09 mg/dL vs 0.76 mg/dL, P < .0001). The estimated glomerular filtration rate (eGFR) was significantly higher in the M→F group than in the F→M group (66.6 mL/min/1.73 m2 vs 50.1 mL/min/1.73 m2, P = .002), and eGFR ratio (recipient to donor) was significantly higher in the M→F group than in the F→M group (1.13 vs 0.57, P < .0001). Multiple linear regression analysis showed that the only the sex of the recipient was significant prognostic factor of eGFR after renal transplantation (P = .037). CONCLUSIONS:The short-term kidney function of the graft from male to female was better than that of the graft from female to male.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Yoneda T,Iemura Y,Onishi K,Hori S,Nakai Y,Miyake M,Anai S,Torimoto K,Aoki K,Saka T,Tanaka N,Yoshida K,Fujimoto K

doi

10.1016/j.transproceed.2016.10.015

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

61-64

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(16)30770-9

journal_volume

49

pub_type

杂志文章

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