Prognostic Value of Levels of Urine Neutrophil Gelatinase-associated Lipocalin and Interleukin-18 in Patients With Delayed Graft Function After Kidney Transplantation.


OBJECTIVE:The aim of our study was to examine how serial urine neutrophil gelatinase-associated lipocalin (uNGAL) and interleukin (IL)-18 concentrations change over time after kidney transplantation and whether we can use them to predict delayed graft function (DGF). METHODS:Spot urine samples for the NGAL and IL-18 tests were taken at 4, 12, 24, 48, and 72 hours after transplantation from every patient at hospital presentation. Urine samples were tested for NGAL by a chemiluminescence assay kit on the ARCHITECT I2000 immunology analyzer. IL-18 were measured by a quantitative immunoenzymatic assay kit. Serum samples for the creatinine measurement were taken at 24, 48, and 72 hours after kidney transplantation. Serum samples were tested for creatinine on the Olympus analyzer 5821 by alkaline picric acid method. The patients were divided into 2 groups: DGF group and non-DGF group. RESULTS:The urine NGAL levels were increased in DGF group at all points over the follow-up period. There are differences (P < .05) in NGAL concentrations between DGF (n = 21) and non-DGF groups (n = 102). However, urine samples from the DGF group (n = 21) had increased IL-18 concentrations at 4, 12, 24, and 48 hours postoperatively compared with non-DGF group samples (n = 102) (P < .05). There were obvious distinctions (P < .05) of serum creatinine (SCr) levels in 24 hours between the DGF (n = 21) and non-DGF groups (n = 102). The specificity and positive predictive value of NGAL in the DGF diagnosis increased with time, but the sensitivity and negative predictive value do not change. The specificity, sensitivity, positive predictive, value and negative predictive value of IL-18 in the DGF diagnosis changed irregularly at multiple time points after transplant. The positive predictive value and negative predictive value of 24-hour SCr were 47.4% and 95.7%, respectively. The positive predictive value and negative predictive value of combination of NGAL, IL-18, and SCr (area under the receiver-operating characteristic curve = 0.984; 95% CI, 0.887-0.994) were 90.9% and 100%, respectively. Overall, the combination of NGAL, IL-18, and SCr was found to have a significantly better positive predictive value than all the other combination assays (P < .05). In addition, there were obvious distinction of the negative predictive value of NGAL and IL-18 combination compared with those of other combinations (P < .05). CONCLUSIONS:The combination of NGAL, IL-18, and SCr measurements after initiation of treatment may be highly effective for risk stratification in patients with DGF. The combination may be useful to cover the complete diagnostic window of patients presenting with DGF.


Transplant Proc


Cui LY,Zhu X,Yang S,Zhou JS,Zhang HX,Liu L,Zhang J




Has Abstract


2015-12-01 00:00:00














  • Severe rhabdomyolysis and acute renal failure in a kidney transplant patient treated with tacrolimus and chimaeric CD25 monoclonal antibody.

    abstract::Recently observations of rhabdomyolysis in patients treated with tacrolimus have been reported. The authors present a kidney transplant patient who had an epileptic seizures, severe rhabdomyolysis, and acute renal failure. The patient was initially immunosuppressed with tacrolimus and chimeric CD25 monoclonal antibody...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Fontana I,Ginevri F,Basile G,Beatini M,Bertocchi M,Bonifazio L,Saltalamacchia L,Ghinolfi D,Santori G,Valente R,Perfumo F,Valente U

    更新日期:2004-04-01 00:00:00

  • Brain death affects the hepatic immunogenicity of pigs.

    abstract:OBJECTIVE:The purpose of this study was to observe how the brain-death state affects the hepatic immunogenicity of pigs. MATERIALS AND METHODS:Twelve healthy ChangBai pigs were allocated randomly to 2 groups: control group (n = 6) with Foley catheter balloon placed intracalvarium for 24 hours only versus brain-death g...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Zhang S,Zhu C,Wu Y,Zhai W,Shi J,Song Y,Li J,Li Z,Zhang G

    更新日期:2008-09-01 00:00:00

  • Living donor transplant: wider selection criteria.

    abstract::The availability of cadaveric donor organs is insufficient for actual needs. The organ demand increases by 20% per year. Living donor transplant (LDT) may be a valid therapeutical alternative provided one uses proper criteria. LDT provides many advantages, like improved patient and organ survival, short waiting time, ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Splendiani G,Cipriani S,Valeri M,Torlone N,Vega A,Tullio T,Condò S,Dominijanni S,Casciani CU

    更新日期:2004-04-01 00:00:00

  • Liver transplantation from maastricht category 2 non-heart-beating donors: a source to increase the donor pool?

    abstract:INTRODUCTION:The demand for liver transplantation has increasingly exceeded the supply of cadaver donor organs. Non-heart-beating donors (NHBDs) may be an alternative to increase the cadaver donor pool. The outcome of 20 liver transplants from Maastricht category 2 NHBD was compared with that of 40 liver transplants fr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Otero A,Gómez-Gutiérrez M,Suárez F,Arnal F,Fernández-García A,Aguirrezabalaga J,García-Buitrón J,Alvarez J,Máñez R

    更新日期:2004-04-01 00:00:00

  • Clinical value of the flow cytometric method for measuring lymphocyte subset activation: spontaneous activation of T-cell subpopulations is associated with acute GvHD.

    abstract::Thymidine ((3)H-TdR) incorporation remains the most commonly used method to quantifying T-cell proliferation. This method, however, does not provide information about specific lymphocyte subpopulations responding to different stimuli. In our study, we modified previously described nonradioactive flow-cytometric T-cell...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kalwak K,Turkiewicz D,Ussowicz M,Gorczyńska E,Toporski J,Ryczan R,Rybka B,Noworolska-Sauren D,Chybicka A

    更新日期:2003-06-01 00:00:00

  • Anesthesia Management and Fluid Therapy in Right and Left Lobe Living Donor Hepatectomy.

    abstract:OBJECTIVE:Right lobe living donor hepatectomy poses a greater risk for the donor in relation to blood loss. The aims of this study were to compare anesthetic and intraoperative fluid management in right and left lateral segment living donor hepatectomy. PATIENTS AND METHODS:The anesthesia records of living donor hepat...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wang CH,Chang KA,Chen CL,Cheng KW,Wu SC,Huang CJ,Shih TH,Yang SC,Juang SE,Huang CE,Jawan B,Lee YE

    更新日期:2018-11-01 00:00:00

  • Laparoscopic living donor nephrectomy for kidneys with multiple arteries.

    abstract:INTRODUCTION:Laparoscopic donor nephrectomy (LDN) involving kidneys with multiple arterial vessels is limited to a small number of reports, with all but two series reporting fewer than 25 patients. Moreover, outside of the pioneering centers at the University of Maryland and Johns Hopkins, no series of at least 25 pati...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Husted TL,Hanaway MJ,Thomas MJ,Woodle ES,Buell JF

    更新日期:2005-03-01 00:00:00

  • A Low-Cost Perfusate Alternative for Ex Vivo Lung Perfusion.

    abstract:BACKGROUND:Normothermic ex vivo lung perfusion (EVLP) has been used successfully to evaluate and recondition marginal donor lungs; however, multiple barriers continue to prevent its widespread adoption. We sought to develop a common hospital ingredient-derived perfusate (CHIP) with equivalent functional and inflammator...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Buchko MT,Himmat S,Aboelnazar NS,Stewart CJ,Hatami S,Dromparis P,Adam B,Freed DH,Nagendran J

    更新日期:2020-12-01 00:00:00

  • Pheohyphomycotic soft tissue disease caused by Alternaria alternata in a kidney transplant patient: a case report and literature review.

    abstract::A 61-year-old Italian man, who underwent a renal transplantation 8 years ago, receiving azathioprine, prednisone, and cyclosporine for immunosuppressive therapy, presented with a large reddish indurated plaque with a central ulcer, which was slowly enlarged, on the right knee. From the diseased tissue biopsy, a demati...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Farina C,Gotti E,Parma A,Naldi L,Goglio A

    更新日期:2007-06-01 00:00:00

  • Health-related quality of life after pediatric liver transplant: single-center experience in Chile.

    abstract:INTRODUCTION:Orthotopic liver transplantation is the treatment of choice for most terminal liver diseases in children. Currently, the improved survival of these patients is well documented, but their quality of life post-transplant is not described. In Chile, Hospital Luis Calvo Mackenna (HLCM) has performed pediatric ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Alba A,Uribe M,Hunter B,Monzón P,Ferrada C,Heine C,Auad H

    更新日期:2013-01-01 00:00:00

  • Rituximab after autologous stem cell transplantation enhances survival of B-cell lymphoma patients: a meta-analysis and systematic review.

    abstract:BACKGROUND:Numerous studies have demonstrated the efficacy of rituximab before autologous stem cell transplantation (ASCT) for the treatment of B-cell non-Hodgkin lymphoma, but the few studies on rituximab treatment after ASCT have not established conclusively the clinical benefits of this particular treatment regimen....

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,meta分析,评审


    authors: He G,Wang C,Tan H,He S

    更新日期:2015-03-01 00:00:00

  • Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation.

    abstract:BACKGROUND/AIMS:Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) recurrences affect both patient and graft survivals post-orthotopic liver transplantation (OLT) in HBV patients with HCC. We analyzed the relationship between HBV and HCC recurrence in a large cohort of HBV-OLT patients with versus without HCC. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kiyici M,Yilmaz M,Akyildiz M,Arikan C,Aydin U,Sigirli D,Nart D,Yilmaz F,Ozacar T,Karasu Z,Kilic M

    更新日期:2008-06-01 00:00:00

  • Long-term Outcomes of ABO-Incompatible Living Donor Kidney Transplantation: A Comparative Analysis.

    abstract:BACKGROUND:Although ABO-incompatible kidney transplantation has become more common due to organ shortage, few studies on long-term outcomes have been performed in the Korean population. METHODS:A retrospective review of medical records was conducted for individuals who underwent living donor kidney transplantation at ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Shin E,Kwon SW,Yang WS,Baeck C,Yu H,Cho H,Park SK

    更新日期:2015-07-01 00:00:00

  • The roles of T cell subpopulations in allograft rejection.

    abstract::In principle, cell-mediated allograft rejection can be brought about by cytotoxic T cells or by a DTH-like reaction. The first part of this article reviews the relative importance of these two mechanisms in graft rejection and concludes that the bulk of evidence points to cytotoxic T cells as being of major importance...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Mason D

    更新日期:1988-04-01 00:00:00

  • Assessment of causes of early death after twenty years of liver transplantation.

    abstract:BACKGROUND:Postoperative poor graft function is a serious complication that can lead to graft loss requiring retransplantation or even death. The postoperative complications of primary nonfunction (PNF), early graft dysfunction (EGD), bleeding due to coagulopathy, and hepatic artery thrombosis (HAT) can lead to graft l...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Azevedo LD,Stucchi RS,Ataíde EC,Boin IF

    更新日期:2013-04-01 00:00:00

  • The effect of complement regulatory protein expression on pig endothelial cells to porcine endogenous retrovirus lyses by human sera.

    abstract:INTRODUCTION:Expression of human complement regulatory proteins (CRP) on pig endothelial cells (PEC) has been useful to avoid hyperacute rejection by human sera. On the other hand, porcine endogenous retrovirus (PERV) from PEC transfectants with CRP may acquire resistance to human sera. In this study, we investigated t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Hazama K,Miyagawa S,Yamamoto A,Kubo T,Miyazawa T,Tomonaga K,Watanabe R,Okumura M,Matsuda H,Shirakura R

    更新日期:2005-01-01 00:00:00

  • Impact of HLA-DPB1 Matching on Outcome of Unrelated Transplant for Hematologic Malignant Diseases: A Systematic Review and Meta-analysis.

    abstract:OBJECTIVE:Human leukocyte antigen match is the most important donor factor affecting transplant outcome. The HLA-DPB1 mismatch on the clinical outcome of hematopoietic stem cell transplant (HSCT) is less clear. This study is the first meta-analysis to investigate the impact of HLA-DPB1 loci mismatch on clinical outcome...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,meta分析


    authors: Wang Y,Xu S,Fang P

    更新日期:2019-01-01 00:00:00

  • Renal transplantation in emigrants from Africa in Spain: similar results but different infectious profile compared with Spanish people.

    abstract::The number of renal transplantation of emigrants from Africa in Europe is increasing. However, there is little information about the results. The aim of this study was to compare the results of renal transplantation among this African emigrant population compared with a matched group of Spanish patients. From 1996-200...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mérida E,Rodríguez A,Hernandez G,Huerta A,Gonzalez J,Hernández A,González E,Morales E,Praga M,Andrés A,Morales JM

    更新日期:2009-07-01 00:00:00

  • Coronary artery calcifications in hemodialysis patients and their correlation with the prevalence of erectile dysfunction.

    abstract:INTRODUCTION:Our aim in this study was to investigate the prevalence and correlation with coronary artery calcium scores (CACS) and erectile dysfunction (ED) among hemodialysis patients. PATIENTS AND METHODS:Thirty-five male patients with chronic renal failure were selected to participate in this study. All patients u...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Inci K,Hazirolan T,Aki FT,Oruc O,Tombul T,Tasar C,Erkan I,Bakkaloglu M,Turgan C,Ergen A

    更新日期:2008-01-01 00:00:00

  • Metaanalysis of statins and survival in de novo cardiac transplantation.

    abstract:BACKGROUND:The use of HMG CoA reductase inhibitors (statins) after cardiac transplantation has been suggested to decrease the incidence of severe rejection and improve survival. Individual investigations that have led to this suggestion are randomized (but not placebo-controlled) studies, including small patient number...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,meta分析


    authors: Mehra MR,Raval NY

    更新日期:2004-06-01 00:00:00

  • Outcome of Living Donor Transplant Kidneys With Multiple Arteries.

    abstract:BACKGROUND:Living donor transplantation (LDT) using kidneys with multiple arteries (MA) has previously been reported to be associated with increased complications and poorer outcomes in recipients. The objective of this study was to investigate outcomes of LDT with MA at the National University Hospital of Singapore, a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lim YM,Han X,Raman L,Ng TK,Goh TH,Vathsala A,Tiong HY

    更新日期:2016-04-01 00:00:00

  • Complete clinical remission of psoriasis 6 months after renal transplantation.

    abstract:BACKGROUND:Psoriasis, one of the most common immune-mediated inflammatory diseases of the skin is mediated by activated effector T cells. CASE REPORT:We report a case of a 56-year-old white man with a 22-year history of severe psoriasis vulgaris with plaque and joint involvement, who experienced a complete clinical re...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Mele C,Salerno MP,Romagnoli J,De Simone C,Castriota M,Citterio F

    更新日期:2013-09-01 00:00:00

  • Indications for and barriers to preemptive kidney transplantation: a review.

    abstract::Preemptive kidney transplantation is the treatment of choice for end-stage renal disease. Compared with nonpreemptive transplantation, preemptive transplantation is significantly associated with improved kidney allograft survival in recipients of either cadaver or living-donor transplants. This seems to be related to ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Kallab S,Bassil N,Esposito L,Cardeau-Desangles I,Rostaing L,Kamar N

    更新日期:2010-04-01 00:00:00

  • More Than 1000 Kidney Transplants Performed in Pamplona, Navarra: Data From the Collaborative Transplant Study.

    abstract:INTRODUCTION:The Kidney Transplant Program started at the Clinica Universidad de Navarra (Pamplona, Spain) in September of 1969. The 1000th kidney transplant was performed in September 2015. Data from kidney transplants have been included in the Collaborative Transplant Study since 1983. MATERIALS AND METHODS:Data on ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Martin Moreno PL,Garcia Fernandez N,Lavilla Royo FJ,Mora Gutiérrez JM,Errasti Goenaga P

    更新日期:2016-11-01 00:00:00

  • Intrabronchial instillation of amphotericin B lipid complex: a case report.

    abstract:OBJECTIVE:We sought to present our results of topical intrabronchial installation of amphotericin B lipid complex (AmpB lipid). PATIENT AND METHODS:A deposit of fungal material was observed in a bilateral lung transplant recipient who experienced stenosis of the left anastomosis and have been fitted with a double endo...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Morales P,Galán G,Sanmartín E,Monte E,Tarrazona V,Santos M

    更新日期:2009-07-01 00:00:00

  • Compound Effect of Kidney Donor Profile Index and Cold Ischemic Time on 1-Year Kidney Transplant Recipient Outcomes.

    abstract:OBJECTIVE:Kidney Donor Profile Index (KDPI) and cold ischemic time (CIT) independently influence recipient outcomes after kidney transplantation; however, the compound effect of these variables on posttransplant outcomes is unknown. DESIGN:The Scientific Registry of Transplant Recipients database of deceased-donor kid...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kutzler HL,Martin ST,O'Sullivan DM,Rochon C

    更新日期:2019-12-01 00:00:00

  • Adult endothelial progenitor cells retain hematopoiesis potential.

    abstract::Hematopoietic stem cells (HSCs) are derived from endothelium in the aortic-gonado-mesonephric (AGM) region during embryogenesis. But little is known about whether endothelial progenitor cells (EPCs) retain hematopoiesis potential after birth. In this study, we isolated adult EPCs from the bone marrow of C57BL/6 mice a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Chen C,Zeng L,Ding S,Xu K

    更新日期:2010-11-01 00:00:00

  • Increasing Use of the Expanded Criteria for Living Kidney Donation and Good Outcomes of Living Kidney Donors in Korea.

    abstract:BACKGROUND:Donor shortage for kidney transplantation may increase the number of expanded-criteria living donors (ECLDs). We investigated recent trends for ECLD use and the long-term outcomes of living kidney donors. METHODS:We retrospectively analyzed medical records of 1,144 living kidney donors who donated at the Se...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lim HJ,Jambaldorj E,Lee Y,Kang SS,Koo TY,Ahn C,Yang J

    更新日期:2016-09-01 00:00:00

  • Liver transplantation in the rat: single-center experience with technique, long-term survival, and functional and histologic findings.

    abstract:OBJECTIVE:Orthotopic liver transplantation (OLT) in rats is frequently used as an experimental model. Numerous surgical techniques have been developed that enable the investigator to conduct clinically relevant studies. The objective of this study was to develop a rat model of acute and chronic rejection, to explicitly...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Matevossian E,Doll D,Hüser N,Brauer R,Sinicina I,Nährig J,Friess H,Stangl M,Assfalg V

    更新日期:2009-07-01 00:00:00

  • Somatopsychic correlates and quality of life of the dialyzed patient: a cross-sectional study.

    abstract:BACKGROUND:The dialysis delivered after a chronic kidney disease (CDK) or any otherwise severe end-stage renal failure is a complex medical task, leading to major medical and psychopathological distress for the patient. The aim of the present study was to analyze the impact of the dialysis experience on the nephrologic...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: De Pasquale C,Pistorio ML,Lauretta I,Fatuzzo P,Fornaro M,Conti D,Di Nuovo S,Sinagra N,Giaquinta A,Zerbo D,Veroux M

    更新日期:2014-09-01 00:00:00