当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Calcineurin-inhibitor-sparing immunosuppressive protocols.

Calcineurin-inhibitor-sparing immunosuppressive protocols.

Abstract：

:Calcineurin inhibitors (CNI) have played an important role in improving graft survival. However, the balance between preventing immunologic allograft losses and the management of CNI-related nephrotoxicity is still an issue in renal transplantation. There are three major CNI-sparing strategies. CNI MINIMIZATION: The advent of mycophenolate mofetil (MMF) allows cyclosporine (CsA) reduction to ameliorate renal function in patients with chronic renal allograft dysfunction, without increasing acute rejection rates. In combination with mTOR inhibitors, very low CNI levels may be sufficient to prevent acute rejection. However, in this association, CNI nephrotoxicity is magnified by pharmacokinetic interaction. CNI WITHDRAWAL: CNI withdrawal has been attempted in regimens containing MMF or sirolimus (SRL). Introduction of MMF in patients with chronic allograft nephropathy (CAN) followed by CNI withdrawal resulted in stabilization or improvement of renal function and hypertension profile, although there is some risk of acute rejection. In regimes based on SRL, CNI withdrawal is a safety strategy, achieving a sustained improvement of renal function, histology, and graft survival. There is not consensus at all whether MMF should be added or not in patients converted from CNI to mTOR inhibitor. CNI AVOIDANCE: Polyclonal-based regimens with MMF and steroids have shown acceptable acute rejection rates, but high rates of cytomegalovirus (CMV) and opportunistic infections. Conversely, anti-IL-2R in combination with MMF and steroids resulted in 50% incidence of acute rejection, thus suggesting that CNI avoidance is not feasible in a regimen based on MMF. Alternatively, a protocol based on anti-IL-2R induction therapy combined with SRL, MMF, and prednisone has shown an efficient prevention of acute rejection, higher creatinine clearance and lower rate of CAN in comparison with a group treated with CNI. New strategies using costimulation blockade may help in the development of safe CNI-free regimens. In summary, in renal transplantation the new immunosuppressive medications have made feasible old aspirations such as minimization, withdrawal, or even avoidance of CNI.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Bestard O,Cruzado JM,Grinyó JM

doi

10.1016/j.transproceed.2005.09.129

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

3729-32

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)01080-8

journal_volume

37

pub_type

杂志文章,评审

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Calcineurin-free protocols with basiliximab induction allow patients included in "old to old" programs achieve standard kidney transplant function.

    abstract：INTRODUCTION:The EuroTransplant "old to old" program establishes that patients older than 60 years can receive offers of organs from donors older than 60 years. The compromised function of these organs makes it a priority to preserve their initial kidney function. HYPOTHESIS:Calcineurin-sparing protocols using anti-IL...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0041-1345(03)00379-8

    authors： Emparan C,Laukötter M,Wolters H,Dame C,Heidenreich S,Senninger N

    更新日期：2003-06-01 00:00:00

  • Critical progressive small-graft injury caused by intrasinusoidal pressure elevation following living donor liver transplantation.

    abstract：:In adult-to-adult living liver transplantation, small-for-size graft syndrome sometimes occurs. The relationship between the hemodynamic changes and histologic findings has not been studied in patients with failure of small-for-size grafts. We analyzed the relationship between the postoperative hemodynamic changes and...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.09.036

    authors： Sugimoto H,Kaneko T,Hirota M,Nagasaka T,Kobayashi T,Inoue S,Takeda S,Kiuchi T,Nakao A

    更新日期：2004-11-01 00:00:00

  • Cyclosporine monitoring in stable, long-term, pediatric kidney transplant recipients: the value of C2 determination.

    abstract：:Although a generalized consensus has been reached for therapeutic drug monitoring of cyclosporine microemulsion in adult transplant patients, clear guidelines are recently not available for the pediatric population. In this retrospective analysis of pharmacokinetic data obtained from stable, long-term, pediatric kidne...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.03.010

    authors： Ferraresso M,Ghio L,Tirelli S,Pedotti P,Taioli E,Edefonti A,Berardinelli L

    更新日期：2004-04-01 00:00:00

  • Isolation and culture of beta-like cells from porcine Wirsung duct.

    abstract：:We sought to develop a protocol to isolate and culture porcine Wirsung duct cells in order to determine their potency to differentiate into insulin-expressing beta-like cells. The porcine Wirsung duct isolated by a surgical microdissection was digested with collagenase P and trypsin to dissociate ductal cells. These e...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.02.062

    authors： Gioviale MC,Damiano G,Montalto G,Buscemi G,Romano M,Lo Monte AI

    更新日期：2009-05-01 00:00:00

  • Tacrolimus-related neurologic and renal complications in liver transplantation: A single-center experience.

    abstract：:Among 71 patients, 19 (26.7%) experienced tacrolimus-related complications including 15 neurologic reactions and four problems with nephrotoxicity. Seven of these patients received grafts from cadaveric donors and 12 from living donors. Nine patients were children. The cohort included 5 female and 14 male subjects of ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.12.114

    authors： Emiroglu R,Ayvaz I,Moray G,Karakayali H,Haberal M

    更新日期：2006-03-01 00:00:00

  • Renal Cell Carcinoma in Kidney Transplant Candidates.

    abstract：BACKGROUND:An increased incidence of renal cell carcinoma (RCC) has been observed in patients with end-stage renal disease. However, the incidence of this pathological condition has not been studied adequately in kidney transplant candidates. The aim of this study was to examine the incidence of RCC and the clinical, i...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.01.087

    authors： Zorbas KA,Karhadkar SS,Lau KN,Di Carlo A

    更新日期：2017-01-01 00:00:00

  • Experimental model of isolated lung perfusion in rats: first Brazilian experience using the IL-2 isolated perfused rat or guinea pig lung system.

    abstract：INTRODUCTION:Lung transplantation has become the mainstay therapy for patients with end-stage lung disease refractory to medical management. However, the number of patients listed for lung transplantation largely exceeds available donors. The study of lung preservation requires accurate, cost-effective small animal mod...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.01.016

    authors： Pêgo-Fernandes PM,Werebe E,Cardoso PF,Pazetti R,de Oliveira KA,Soares PR,Jatene FB

    更新日期：2010-03-01 00:00:00

  • Effects of tolerance induction on the actions of interferon-gamma on porcine cardiac allografts.

    abstract：:It is well known that interferon-gamma (IFN-gamma) not only plays a critical role in antigen-dependent but also in antigen-independent tissue injury; however, it is not clear how tolerance induction affects the actions of IFN-gamma in the transplant setting. To address this question, we compared the effects of IFN-gam...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.119

    authors： Hoerbelt R,Benjamin LC,Shoji T,Johnston DR,Muniappan A,Guenther DA,Allan JS,Houser SL,Madsen JC

    更新日期：2006-12-01 00:00:00

  • Liver transplantation in patients with hepatocellular carcinoma: one center's experience.

    abstract：:Hepatocellular carcinoma (HCC), which worldwide is the fifth most common malignancy in men and the ninth most common malignancy in women, accounts for 6% of all malignant lesions. We evaluated our results of liver transplantation for patients with HCC. Between January 2004 and April 2007, 31 patients (5 females, 26 ma...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.11.006

    authors： Karakayali H,Sevmis S,Moray G,Yilmaz U,Ozcay F,Savas NA,Arslan G,Haberal M

    更新日期：2008-01-01 00:00:00

  • Estimation of standard liver volume in Chinese adult living donors.

    abstract：AIM:To determine a formula predicting the standard liver volume based on body surface area (BSA) or body weight in Chinese adults. MATERIALS AND METHODS:A total of 115 consecutive right-lobe living donors not including the middle hepatic vein underwent right hemi-hepatectomy. No organs were used from prisoners, and no...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.08.079

    authors： Fu-Gui L,Lu-Nan Y,Bo L,Yong Z,Tian-Fu W,Ming-Qing X,Wen-Tao W,Zhe-Yu C

    更新日期：2009-12-01 00:00:00

  • Cryopreservation of insulin-producing cells microencapsulated in sodium cellulose sulfate.

    abstract：INTRODUCTION:Diabetes mellitus may be treated with pancreatic islet cell transplantation. The use of xenogenic islet cells may overcome the shortage of human donor organs. Microencapsulation seems to be a promising method for immunoprotection. Since isolation, purification, encapsulation, and transplantation of islet c...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.08.188

    authors： Stiegler PB,Stadlbauer V,Schaffellner S,Halwachs G,Lackner C,Hauser O,Iberer F,Tscheliessnigg K

    更新日期：2006-11-01 00:00:00

  • Management of uncommon hernias in cirrhotic patients.

    abstract：BACKGROUND:Abdominal hernias are a common disease among cirrhotic patients, because of malnutrition and persistently high intra-abdominal pressure due to ascites. When tense ascites is present, life-threatening complications are likely to occur. In such cases, the morbidity and mortality rates are high. OBJECTIVE:We d...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.090

    authors： Andraus W,Sepulveda A,Pinheiro RS,Teixeira AR,D'Albuquerque LA

    更新日期：2010-06-01 00:00:00

  • Liver transplantation for hilar cholangiocarcinoma: a German survey.

    abstract：BACKGROUND:The present study reports a German survey addressing outcomes in nonselected historical series of liver transplantation (OLT) for hilar cholangiocarcinoma (HL). PATIENTS AND METHODS:We sent to all 25 German transplant centers performing OLT a survey that addressed (1) the number of OLTs for HL and the perio...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2008.08.039

    authors： Kaiser GM,Sotiropoulos GC,Jauch KW,Löhe F,Hirner A,Kalff JC,Königsrainer A,Steurer W,Senninger N,Brockmann JG,Schlitt HJ,Zülke C,Büchler MW,Schemmer P,Settmacher U,Hauss J,Lippert H,Hopt UT,Otto G,Heiss MM,Bechste

    更新日期：2008-11-01 00:00:00

  • Intrahepatic cholangiocarcinoma arising in chronic viral hepatitis-associated cirrhosis: two transplant cases.

    abstract：:Hepatitis C virus (HCV) or hepatitis B virus (HBV)-related cirrhosis is known to be a risk factor for hepatocellular carcinoma (HCC). Recently, these viruses have been reported to have an etiologic role in the development of intrahepatic cholangiocarcinoma (ICC). Herein we have reported two cases of HCV- and HBV-relat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.06.071

    authors： Nart D,Ertan Y,Pala EE,Zeytunlu M,Kilic M,Yilmaz F

    更新日期：2008-12-01 00:00:00

  • Immunologic tolerance: tailored antigen.

    abstract：:In summary, synthetic peptides corresponding to linear sequences of HLA class I molecules can inhibit T-cell responses in vitro and in vivo. These peptides induce immunologic tolerance by binding to hsp-70 family members, causing an increase in intracellular calcium, and down-regulating the nuclear factor of activated...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：

    authors： Krensky AM,Clayberger C

    更新日期：1996-08-01 00:00:00

  • Predictors of Mortality in Living Donor Liver Transplantation.

    abstract：BACKGROUND:Egypt has the highest prevalence of the world hepatitis C virus (HCV) load. Hence, the problem of end-stage liver disease (ESLD) is considered a huge burden on the community. Living donor liver transplantation (LDLT) is the only source of donation in Egypt till now. Survival rates had shown significant impro...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.02.055

    authors： Elkholy S,Mogawer S,Hosny A,El-Shazli M,Al-Jarhi UM,Abdel-Hamed S,Salah A,El-Garem N,Sholkamy A,El-Amir M,Abdel-Aziz MS,Mukhtar A,El-Sharawy A,Nabil A

    更新日期：2017-01-01 00:00:00

  • Addition of cladribine to induction/consolidation regimen does not impair peripheral blood stem cell mobilization and bone marrow harvest for autotransplantation in acute myeloid leukemia patients.

    abstract：BACKGROUND:The previous study by the Polish Adult Leukemia Group has demonstrated that addition of cladribine to standard DNR+AraC induction potentiates the antileukemic activity. The goal of this study was to compare the efficacy of bone marrow or peripheral blood hematopoietic cell collection in patients who obtained...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.10.100

    authors： Holowiecki J,Grosicki S,Sadus-Wojciechowska M,Kachel L,Hellmann A,Mital A,Skotnicki AB,Piatkowska-Jakubas B,Jedrzejczak WW,Paluszewska M,Wach M,Marianska B,Wrzesien-Kus A,Krawczyk-Kulis M,Wojnar J

    更新日期：2005-12-01 00:00:00

  • Cytomegalovirus infections in cardiac transplant patients: an experience at a clinical hospital, university of Chile.

    abstract：BACKGROUND:Since cytomegalovirus (CMV) infects between 20% and 50% of heart transplant patients, we reviewed our experience in 7 cases of this infection. METHODS:A prospective analysis of CMV infection was performed in heart transplant patients who received cyclosporine, azathioprine, or mycophenolate mofetil, and pre...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.12.030

    authors： Sepulveda L,Llancaqueo M,Zamorano J,Bermudez C,Cortes C

    更新日期：2007-04-01 00:00:00

  • Upper aerodigestive tract and lung tumors after liver transplantation.

    abstract：BACKGROUND:The purpose of this study was to analyze the incidence, clinical characteristics, treatment, and outcome of upper aerodigestive (UAD) and lung de novo tumors after ortothopic liver transplantation (OLT). PATIENTS AND METHODS:Between April 1986 and June 2002, we performed 851 OLT in 753 patients. We excluded...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00641-9

    authors： Jiménez C,Marqués E,Loinaz C,Romano DR,Gómez R,Meneu JC,Hernández-Vallejo G,Alonso O,Abradelo M,Garcia I,Moreno E

    更新日期：2003-08-01 00:00:00

  • HLA-D typing with an association of Dw2 and absent immune responses towards herpes simplex (type i) antigen in multiple sclerosis.

    abstract：:We have confirmed that HLA-Dw2 is increased in MS patients to 47% (normals 20%). Lymphocyte transformation and antibody studies with herpes simplex antigen show that many of the DW2-positive MS patients have low or absent responses. The association of low responses to HSV and the presence of Dw2 is statistically signi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Paty DW,Cousin HK,Stiller CR,Boucher DW,Furesz J,Warren KG,Marchuk L,Dossetor JB

    更新日期：1977-12-01 00:00:00

  • Transfection of hairpin small interfering RNA expression vector targeting rat nuclear factor (NF) (κB) inhibits rat cell proliferation induced by NF-κB signal pathway activation.

    abstract：OBJECTIVE:The aim of this work was to construct one small interfering RNA (siRNA) eukaryotic expression vector targeting rat nuclear factor (NF)κB p65 and identify its inhibition effect on cell proliferation according to its down-regulation of NF-κB pathway. METHODS:The p65siRNA expression vector "pGenesil-1.2-p65siRN...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.09.168

    authors： He XP,Li XX,Wang ZH,Bi YW,Liu FY,Liu XY

    更新日期：2010-12-01 00:00:00

  • Quality of life after simultaneous pancreas-kidney transplantation.

    abstract：:Even recipients with satisfactory function of transplanted pancreas and kidney may show physical and/or social disability due to diabetic complications. Our aims were to evaluate diabetic complications influencing recipient quality of life and to assess patients' psychosociological status. Nineteen patients with funct...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.09.083

    authors： Kwiatkowski A,Michalak G,Czerwinski J,Wszola M,Nosek R,Ostrowski K,Chmura A,Danielewicz R,Lisik W,Adadynski L,Malkowski P,Fesolowicz S,Bieniasz M,Kasprzyk T,Bernas M,Szczeklik-Kumala K,Glowania A,Durlik M,Walaszewski

    更新日期：2005-10-01 00:00:00

  • Association of hyperglycemia on allograft function in the early period after renal transplantation.

    abstract：:Hyperglycemia is common following renal transplantation. This study was conducted to evaluate the relationship of perioperative serum glucose levels and acute rejection in 100 nondiabetic patients who underwent renal transplantation. Blood glucose was measured immediately following surgery and every 6 hours during the...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.03.030

    authors： Ganji MR,Charkhchian M,Hakemi M,Nederi GH,Solymanian T,Saddadi F,Amini M,Najafi I

    更新日期：2007-05-01 00:00:00

  • A preliminary study on the feasibility of gene expression profile of rhesus monkey detected with human microarray.

    abstract：OBJECTIVES:A pig-to-monkey transplant model was initiated to investigate the outcome of pig-to-human xenotransplantation. Though monkey is close to human in biology and physiology, the genetic differences between the two species remains unclear. This study sought to compare the gene expressions of three tissues from hu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.01.029

    authors： Lu YR,Wang LN,Jin X,Chen YN,Cong C,Yuan Y,Li YC,Tang WD,Li HX,Wu XT,Li YP,Wang L,Cheng JQ

    更新日期：2008-03-01 00:00:00

  • Manufacturing of insulin-secreting spheroids with the RIN-5F cell line using a shaking culture method.

    abstract：BACKGROUND:There have been many efforts to find methods to increase insulin production by islets or modified cells. Commercially available established cell lines can be a good source of artificial islets. We manufactured sphere-shaped cell clusters composed of insulin-secreting cells from the commercially available RIN...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.09.090

    authors： Joo DJ,Kim JY,Lee JI,Jeong JH,Cho Y,Ju MK,Huh KH,Kim MS,Kim YS

    更新日期：2010-12-01 00:00:00

  • Does multiorgan versus kidney-only cadaveric organ procurement affect graft outcomes?

    abstract：INTRODUCTION:The majority of kidney grafts in most European countries still come from deceased donors who provide other organs. We analyzed whether multiorgan procurement portends a worse functional outcome compared with kidney-only harvesting. METHODS:We performed a retrospective analysis of 1043 consecutive brain-de...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.02.026

    authors： Castelo D,Campos L,Moreira P,Furriel F,Parada B,Nunes P,Figueiredo A,Mota A

    更新日期：2013-04-01 00:00:00

  • Mechanism for the Instant Blood-Mediated Inflammatory Reaction in Rat Islet Transplantation.

    abstract：OBJECTIVE:The purpose of this study was to investigate the mechanisms involved in the development of instant blood-mediated inflammatory reaction (IBMIR) triggered by pancreatic islet transplantation in an in vitro system. MATERIALS AND METHODS:Pancreatic islets were prepared and blood was taken from male and female W...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.03.090

    authors： Cheng Y,Wang B,Li H,Zhao N,Liu Y

    更新日期：2017-01-01 00:00:00

  • Intrauterine growth restriction in pregnant renal and liver transplant recipients: risk factors assessment.

    abstract：BACKGROUND:Nowadays pregnancy after organ transplantation is possible due to advances in surgical and immunosuppressive therapies. One of the possible complications in pregnancy after organ transplantation is intrauterine growth restriction (IUGR). This may lead to various adverse perinatal outcomes. Prevalence of IUGR...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.09.001

    authors： Cyganek A,Pietrzak B,Kociszewska-Najman B,Grzechocińska B,Songin T,Foroncewicz B,Mucha K,Wielgoś M

    更新日期：2014-10-01 00:00:00

  • A prospective comparison of bladder versus enteric drainage in vascularized pancreas transplantation.

    abstract：:Although the number of pancreas transplants has increased significantly in previous years, debate continues concerning the optimum technique for exocrine pancreas drainage. Enteric drainage (ED) has recently been increasingly popular due to the long-term complications with bladder drainage (BD). We prospectively assig...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.05.027

    authors： Adamec M,Janousek L,Lipár K,Hampl F,Saudek F,Koznarová R,Boucek P,Havrdová T

    更新日期：2004-05-01 00:00:00

  • Dose/time-dependent modulation of the endothelial function through induction agents: non-depleting versus depleting agents.

    abstract：BACKGROUND:Polyclonal anti-thymocyte globulins (ATGs) and anti-CD25 antibodies are agents used for induction of immunosuppression in solid-organ transplantation. We aimed to investigate the effect of different regimens of these immunosuppressive induction agents on transendothelial migration of peripheral blood mononuc...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.06.055

    authors： Werner I,Bogert NV,Stock UA,Moritz A,Beiras-Fernandez A

    更新日期：2014-11-01 00:00:00