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Cyclosporine monitoring in stable, long-term, pediatric kidney transplant recipients: the value of C2 determination.

Abstract：

:Although a generalized consensus has been reached for therapeutic drug monitoring of cyclosporine microemulsion in adult transplant patients, clear guidelines are recently not available for the pediatric population. In this retrospective analysis of pharmacokinetic data obtained from stable, long-term, pediatric kidney transplant recipients, we sought to define a possible approach to manage cyclosporine therapy in a pediatric setting. The 2-hour postdose cyclosporine blood concentration, C(2), rather than trough levels, was the best single time point predictor of the area under the concentration curve. We concluded that therapeutic drug monitoring of cyclosporine-based immunosuppressive regimens should be tailored based on C(2) determinations for pediatric kidney transplant recipients.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Ferraresso M,Ghio L,Tirelli S,Pedotti P,Taioli E,Edefonti A,Berardinelli L

doi

10.1016/j.transproceed.2004.03.010

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

685-6

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041134504002386

journal_volume

36

pub_type

杂志文章

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