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Use of cyclosporine in renal transplantation.

Abstract：

:Since 1983, cyclosporine has been the backbone of immunosuppression in clinical organ transplantation. Cyclosporine is usually used in combination with steroids and with another second-line immunosuppressant like azathioprine or mycofenolate mofetil. With these regimens, graft survival at 1 year exceeds 90% and long-term results are excellent. The main complication is renal toxicity, which is usually secondary to excessive exposure. The new microemulsion formulation of cyclosporine, introduced in recent years, has improved intestinal absorption and bioavailability and resulted in much less intrapatient variation than the older formulation. The introduction of 2-hour peak blood level monitoring, which corresponds closely to the area under the curve of the drug, allows more appropriate dosing, thus minimizing rejection owing to underexposure or toxicity owing to overexposure. As new effective immunosuppressants are currently becoming available for use in combination with cyclosporine, the transplant community can look forward to more effective and safer immunosuppression.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Kyriakides G,Miller J

doi

10.1016/j.transproceed.2004.01.112

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

167S-172S

issue

2 Suppl

eissn

0041-1345

issn

1873-2623

pii

S0041134504001320

journal_volume

36

pub_type

杂志文章,评审

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