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Acute Liver Failure Caused by Primary Non-Hodgkin's Lymphoma of the Liver.

Abstract：

INTRODUCTION:Acute liver failure (ALF) is a rare syndrome involving maximum liver dysfunction. This disease is characterized by a less than 26-week history of coagulopathy (INR ≥1.5) and hepatic encephalopathy and generally occurs in patients without any previously known disease. METHODS:We report the case of a healthy 25-year-old subject who presented with fulminant liver failure caused by a primary non-Hodgkin's lymphoma of the liver that required emergency liver transplantation. Diagnosis was based on pathologic confirmation of T-cell/histiocyte-rich large B-cell lymphoma and submassive hepatocyte necrosis. One year after surgery, the patient remains in complete remission. CONCLUSIONS:Fulminant liver failure is a sudden-onset severe disease that can be caused by a primary non-Hodgkin's lymphoma of the liver, which accounts for <1% of extranodal lymphomas. The diagnosis of this rare disease demands high diagnostic suspicion, and progression can be prevented through liver transplantation.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Romacho López L,León Díaz FJ,Sánchez Pérez B,Pérez Daga JA,Fernández Aguilar JL,Montiel Casado MC,Aranda Narváez JM,Suárez Muñoz MA,Santoyo Santoyo J

doi

10.1016/j.transproceed.2016.10.005

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

3000-3002

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(16)30754-0

journal_volume

48

pub_type

杂志文章

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