Relationship of renal resistive index and cardiovascular disease in renal transplant recipients.

Abstract:

BACKGROUND:Cardiovascular disease is the primary cause of death in renal transplant recipients, and elevated renal allograft resistive index (RI) has been associated with patient survival. OBJECTIVE:To evaluate the predictive value of intrarenal RI on atherosclerotic disease. PATIENTS AND METHODS:Ninety-seven patients who had undergone renal transplantation between 1999 and 2001 and had stable renal function were included in the study. Patients with renal artery stenosis, urinary tract obstruction, clinical symptoms of acute rejection, or chronic allograft nephropathy were excluded. Clinical and laboratory information was obtained from the medical records and included demographic data, medications used, body mass index, blood pressure, and laboratory values. Intrarenal RI and carotid intima-media thickness (IMT) were determined using Doppler ultrasonography. RESULTS:At linear regression analysis, RI was significantly correlated with recipient age, C-reactive protein concentration, systolic blood pressure, pulse pressure, body mass index, smoking, and carotid IMT. At multivariate linear regression analysis, only pulse pressure was an independent predictor of intrarenal RI. CONCLUSION:Intrarenal RI is associated with traditional cardiovascular risk factors and carotid IMT. Elevated intrarenal graft RI may be predictive of cardiovascular disease in renal transplant recipients without complications.

journal_name

Transplant Proc

authors

Akgul A,Sasak G,Basaran C,Colak T,Ozdemir FN,Haberal M

doi

10.1016/j.transproceed.2009.07.023

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

2835-7

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)01058-6

journal_volume

41

pub_type

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