Abstract：
:The objective of the study was to assess the efficacy of antiviral therapy in patients with hepatitis C virus (HCV) recurrence after liver transplantation (OLT). We included 30 patients of mean age 56 years, who experienced HCV recurrence after OLT. Mean time from OLT to the beginning of therapy was 57 months (median: 43 months). All of them were on monotherapy: tacrolimus (n = 21), cyclosporine (n = 6), and mycophenolate mofetil (n = 3). Fourteen had previously been diagnosed with allograft HCV cirrhosis. Patients were treated with peginterferon alpha 2b (1.5 mug/kg/weekly SC) and ribavirin (10.6 mg/kg/d) for 48 (genotypes 1, 4) or 24 weeks (genotypes 2, 3). After a mean follow-up of 20 months, two patients had died due to biliary sepsis (while on therapy) and acute myocardial infarction (7 months after the end of therapy). End of treatment virological response was achieved in 19 patients (63.3%) and sustained virological response (SUR) in 14 (46.7%). Comparing cirrhotic and noncirrhotic patients, SVR was achieved in seven patients in both groups (50% vs 43.8%; P = .732). Every patient had some adverse event; in 11 patients (36.7%) it was withdrawn (seven cirrhotic and four noncirrhotic; P < .05), and in 12 the starting dose was decreased (40%). There were neither rejection episodes nor cirrhotic complications during therapy, but infections were more common in cirrhotic patients (57% vs 25%; P < .05). In HCV cirrhotic transplanted patients the sustained virological response to combined antiviral therapy was similar to that in noncirrhotic patients, but severe adverse events including infections were much more common.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Moreno Planas JM,Rubio Gonzalez E,Boullosa Graña E,Garrido Botella A,Barrios Peinado C,Lucena Poza JL,Jiménez Garrido M,Sanchez Turrion V,Cuervas-Mons Martinez Vdoi
10.1016/j.transproceed.2005.03.124subject
Has Abstractpub_date
2005-06-01 00:00:00pages
2207-8issue
5eissn
0041-1345issn
1873-2623pii
S0041-1345(05)00367-2journal_volume
37pub_type
杂志文章abstract：BACKGROUND:The National Transplant Center in Mexico has ruled that deceased-donor kidney allocation is a function of each hospital's Internal Transplant Committee. The aim of this study was to compare and analyze results for of the traditional method and a point-score system in the allocation of deceased patient's kidn...
journal_title：Transplantation proceedings
pub_type： 杂志文章,多中心研究
doi：10.1016/j.transproceed.2011.09.091
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:After its initial difficulties were overcome, lung transplantation became an accepted and effective treatment for end-stage lung disease. Patients can take part in almost all kinds of sports after lung transplantation, including high-altitude mountaineering, which is an extreme sport even for healthy individ...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2019.04.004
更新日期：2019-05-01 00:00:00
abstract：BACKGROUND:Liver transplant recipients often have violent hemodynamic fluctuation during surgery that may be related to perioperative and postoperative morbidity. Because there are some considerations for the risk of the pulmonary arterial catheter (PAC), the conventional invasive device for cardiac output (CO) measure...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2015.12.070
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Animal models of partial hepatic ischemia-reperfusion injury (IRI) have potential benefits for decision making and clinical management after liver transplantation or massive hepatic resection. We evaluated changes in apparent diffusion coefficient (ADC) in rabbits with partial hepatic IRI using 3.0 T magneti...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2011.01.183
更新日期：2011-06-01 00:00:00
abstract：:Since November 1974, heterotopic cardiac transplants have been performed at this unit in preference to orthotopic transplants. A number of reasons have led us to prefer this technique, namely donor malfunction in the immediate postoperative period and during rejection; right ventricular failure of the donor heart in t...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
abstract：OBJECTIVES:Pediatric liver transplant (OLT) patients are at risk of posttransplant lymphoproliferative disease (PTLD) from Epstein-Barr virus (EBV). This study examined the impact of induction and immunosuppression on EBV viremia. METHODS:A retrospective chart review was performed on 197 pediatric patients and inducti...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2012.04.035
更新日期：2013-01-01 00:00:00
abstract：:Hypertension is a frequent cardiovascular risk factor in liver transplant recipients. The usefulness of ambulatory blood pressure monitoring (ABPM) in these patients is unknown. This study was aimed at evaluating the circadian rhythms of blood pressure in liver allograft recipients. In 53 liver transplant patients blo...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2005.02.036
更新日期：2005-04-01 00:00:00
abstract：INTRODUCTION:A prospective, randomized, multicenter, open clinical trial was performed to compare the main liver function tests, postoperative complications, and early graft and patient survival of recipients transplanted with livers preserved in Celsior (CEL) versus histidine tryptophan ketoglutarate (HTK) solutions. ...
journal_title：Transplantation proceedings
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.transproceed.2004.11.028
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:Replacement of β-cells with the use of isolated islet allotransplantation (IT) is an emerging therapy for type 1 diabetics with hypoglycemia unawareness. The current standard protocol calls for a 36-72-hour culture period before IT. We examined 13 clinical islet preparations with ≥2 purity fractions to deter...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2014.06.011
更新日期：2014-07-01 00:00:00
abstract：:Adult respiratory distress syndrome is a severe respiratory failure due to noncardiogenic pulmonary edema with high mortality rates (50-70%). The most common etiology of respiratory distress is sepsis, but it may also be caused by several of the immunosuppressants prescribed in transplantation. In the last year, influ...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2013.06.015
更新日期：2013-11-01 00:00:00
abstract：INTRODUCTION:Our previous reports suggested that African Americans (AA) are more likely to develop end-stage renal disease (ESRD) following kidney donation when compared with white counterparts. We sought information on age, gender, and race of kidney donors to determine which groups were over-represented on the kidney...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.03.104
更新日期：2008-06-01 00:00:00
abstract：:We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-l-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. The effects of LARG on hepa...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2009.02.050
更新日期：2009-04-01 00:00:00
abstract：:Following adoptive transfer into irradiated recipients, thymocytes can be induced to respond strongly to vaccinia virus. High levels of cytotoxic T-lymphocyte (CTL) activity may be generated from thymus, but not from spleen, of 3-day-old mice. The capacity of thymocytes to differentiate into effector CTL tends to be l...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：:Brain death (BD) is not a stable, objective condition; in fact, it strongly depends on early intensive treatment before death, brain stem reflex testing, and intensive care unit (ICU) physician attitudes. Consequently, unpredictable "silent" BDs due to inadequate treatment or omitted declaration may affect potential o...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2010.05.042
更新日期：2010-07-01 00:00:00
abstract：:The so-called learning factor has been disregarded for many years in analyzing the causes of surgical complications and post-operative mortality; it is also the case for OLT. In our center until April 2003, 209 OLT were performed in 196 patients. We evaluated the impact of experience of the transplantation team on the...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/s0041-1345(03)00834-0
更新日期：2003-09-01 00:00:00
abstract：:Serial Doppler sonographic impedance measurements represent the most common diagnostic method for noninvasive monitoring of kidney grafts. Severely elevated arterial impedance is almost always associated with graft dysfunction. However, we describe in the present work a renal transplant recipient with optimal graft fu...
journal_title：Transplantation proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0041-1345(03)00623-7
更新日期：2003-08-01 00:00:00
abstract：:Encapsulating peritoneal sclerosis is a serious complication of peritoneal dialysis and can occur even after transplant. The gut is partially or totally enveloped by a thick fibrous membrane that leads to the formation of multiple sections containing intestinal loops contracted and reduced in volume. Exacerbation afte...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2014.07.060
更新日期：2014-09-01 00:00:00
abstract：:An evolution of understanding and knowledge gained over more than 100 years in the field of solid organ transplantation (SOT) led to the first successful clinical cases of composite tissue allotransplantation. In many ways reconstructive transplantation (RT) is similar to SOT; however, certain characteristics make thi...
journal_title：Transplantation proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.transproceed.2011.08.044
更新日期：2011-11-01 00:00:00
abstract：:Basiliximab is considered to be effective in preventing cellular rejection (CR) in solid organ transplantation and is commonly used for renal transplants. The aim of this study was describe the population of patients undergoing orthotopic liver transplantation (LT) receiving basiliximab in the period 2012-2016 in the ...
journal_title：Transplantation proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.transproceed.2017.01.047
更新日期：2017-05-01 00:00:00
abstract：:Previous studies have shown that vaccinating rodents with anti-donor-specific T cells significantly prolonged allograft survival; however, the putative mechanism of the tolerance remains unclear. In this study, we used the model of heterotopic heart transplantation between the C57BL/6 donor mice and BALB/c recipient m...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.02.079
更新日期：2008-06-01 00:00:00
abstract：:Two young men developed nephrotic syndrome associated with Hodgkin's lymphoma and progressive renal failure. After a short course of hemodialysis with blood transfusion, each received a cadaveric renal transplant. During the postoperative period, chemotherapy (MOPP) was given. No transplant rejection episodes were dia...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：
更新日期：1984-10-01 00:00:00
abstract：BACKGROUND:Although the clinical outcomes of pediatric renal transplantation (RT) in developed countries have improved significantly, the data on clinical outcomes in developing countries are wildly different. METHODS:Children and adolescents who had undergone RT at Ramathibodi Hospital between March 2001 and August 2...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2017.03.027
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:Reperfusion of the ischemic liver results in the generation of oxidative and nitrosative stresses and reaction product of peroxynitrite, which induce rapid cytotoxicity and liver injury. In this study we demonstrated that curcumin, an antioxidant, attenuated ischemia/reperfusion (I/R)-induced liver injury. M...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2012.01.081
更新日期：2012-05-01 00:00:00
abstract：:Immunosuppressive regimens in the early precyclosporine days of liver transplantation for the Cambridge-King's Programme from 1968 until the early 1980s were inadequate in the control of rejection. The consequent use of high-dose steroids led to many infections, which seriously affected outcome. Nevertheless, occasion...
journal_title：Transplantation proceedings
pub_type： 历史文章,杂志文章
doi：10.1016/j.transproceed.2004.01.007
更新日期：2004-03-01 00:00:00
abstract：BACKGROUND:From 1968 until 1997, transplantation-related activities were not properly regulated and were informally practiced. During 20 years, many legal and political changes influenced it. OBJECTIVE:To provide a historical overview of the 20 years with a descriptive data analysis of a 20-year data set. METHODOLOGY...
journal_title：Transplantation proceedings
pub_type： 历史文章,杂志文章
doi：10.1016/j.transproceed.2020.01.075
更新日期：2020-06-01 00:00:00
abstract：:Liver transplantation (OLT) remains a major medical and surgical challenge in small patients. From October 1997 through July 2004, 17 babies less than 6 kg underwent 18 OLTs. Median age and weight were 3 months (range = 1 to 9) and 4.7 kg (range = 2.2 to 5.8). Two whole, one reduced, and 15 split-liver grafts (left la...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2004.12.307
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To establish the knowledge, attitudes, and behaviors of the officials of religion, a group with potentially powerful influence on the society, in particular regarding organ donation. METHODS:This study, performed in Kahramanmaras Province, Turkey, included 416 of 641 officials of religion (64.9%): 295 of 492...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2010.08.035
更新日期：2010-11-01 00:00:00
abstract：:Scandiatransplant is the Nordic organ exchange organization. It has existed for 35 years and it is owned by all organ transplantation hospital departments in the five Nordic countries--Denmark, Finland, Iceland, Norway, and Sweden. The use of living organ donors for kidney transplantation has become a more common proc...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2005.09.064
更新日期：2005-10-01 00:00:00
abstract：:In conventionally described simultaneous pancreas-kidney transplantation with portoenteric drainage, renal revascularization is derived from the left iliac vessels and pancreatic revascularization, from the right iliac artery. A newer technique utilizing the right iliac artery as a single inflow to both organs is desc...
journal_title：Transplantation proceedings
pub_type： 杂志文章
doi：10.1016/j.transproceed.2008.04.013
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to assess a Simulect (basiliximab) regimen in routine clinical practice in the Spanish kidney transplantation units to evaluate efficacy and safety. METHODS:In this prospective, observational study, data on demographics, parameters of efficacy, and safety in patients who under ...
journal_title：Transplantation proceedings
pub_type： 杂志文章,多中心研究
doi：10.1016/s0041-1345(03)00575-x
更新日期：2003-08-01 00:00:00
