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Liver transplantation in fulminant hepatic failure: experience with 40 adult patients over a 17-year period.

Abstract：

INTRODUCTION:To evaluate the influence of pretransplantation recipient and donor prognostic factors on graft-patient survival. MATERIALS AND METHODS:Between April 1986 and June 2003, 40 liver transplantation (LT) procedures to treat fulminant hepatic failure were performed (5.7%). Twenty-one pre-LT recipient and donor variables were retrospectively considered for analysis. RESULTS:The indications for LT were hyperacute (62.5%), acute (35%), and subacute hepatic failure (2.5%). Glasgow Coma Scale scores ranged from <5 in 22 patients to > or =5 in 18 patients. The causes were hepatitis B (n = 21), unknown (n = 10), Amanita phalloides (n = 5), and other (n = 4). The 1-year graft and patient survival rates were 48.3% and 61.3%, respectively. Perioperative and late mortality was 27.5% and 22.5%. The only variable statistically significant for graft survival was waiting list time for LT <48 hours (P = .05). DISCUSSION:Liver transplantation is the best treatment for fulminant hepatic failure, with a 1-year patient survival rate of 61.3%. The short waiting list time has an important role in outcome.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Montalti R,Nardo B,Beltempo P,Bertelli R,Puviani L,Cavallari A

doi

10.1016/j.transproceed.2004.12.225

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

1085-7

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)01683-5

journal_volume

37

pub_type

杂志文章

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