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Liver transplant combined with heart transplant in severe heterozygous hypercholesterolemia: report of the first case and review of the literature.

Abstract：

:Familial hypercholesterolemia (FH) is a dominant inherited disease of low-density lipoprotein (LDL) metabolism caused by mutations of LDL receptors mainly located in the liver. This metabolic disorder is responsible for severe cardiovascular disease, from coronary lesions to chronic heart failure (CHF). Liver transplantation in homozygous FH provides the missing functional LDL receptors and thus partially restores LDL receptor activity to more than 50% of normal. Combined heart and liver transplantation was successfully performed in a homozygous FH patient with end-stage heart failure. Herein we report our experience with a heterozygous male patient with terminal CHF, and review data from the literature on short- and long-term results of such procedures.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Alkofer BJ,Chiche L,Khayat A,Deshayes JP,Lepage A,Saloux E,Reznik Y

doi

10.1016/j.transproceed.2005.03.037

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

2250-2

issue

5

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00274-5

journal_volume

37

pub_type

杂志文章,评审

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