Abstract:
:Renal transplantation is currently the most effective treatment for end-stage kidney diseases, and acute allograft rejection is well treated with high dose prednisolone and immunosuppressive agents, but long-term use of immunosuppressants will be detrimental to the long-term survival of the transplanted kidney and will have many side effects on the human body. Thus, a local and alloantigen-specific immunological tolerance may be a promising approach to improving kidney transplantation. The aim of this study is to examine the therapeutic potential of transforming bone marrow-derived mesenchymal stem cells (BMSCs) pretreated with erythropoietin (EPO) in inducing immunosuppression in renal grafts after transplantation. The immunity suppression effects were tested, focusing on the decrease of serum creatinine and the cells' ability to regulate the expression of the cytokines associated with acute rejection. Our findings demonstrate that a transfusion of BMSCs pretreated with EPO (EPO-BMSCs) can produce an immunosuppressive effect and reduce the occurrence of acute rejection. Their reciprocal effects on the induction and function of regulatory T cells (Tregs) resulted in the balance of IFN-γ/IL-4 and improved immunosuppressive effects in local kidney grafts. Our data also suggest that the acute rejection microenvironment had a directional chemotactic effect on BMSCs, which is related to the upregulation of CXCR4, and could be further enhanced by EPO treatment. Thus, transfusion of EPO-BMSCs can induce a greater local immunosuppressive effect in renal grafts after transplantation compared with untreated BMSCs. Therefore, transplantation with EPO-BMSCs can be a novel and effective approach to lower the acute rejection ratio following transplantation.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Zhang Y,Zhou S,Hu JM,Chen H,Liu D,Li M,Guo Y,Fan LP,Li LY,Liu YG,Zhao Mdoi
10.1016/j.transproceed.2018.04.063subject
Has Abstractpub_date
2018-12-01 00:00:00pages
3873-3880issue
10eissn
0041-1345issn
1873-2623pii
S0041-1345(18)30660-2journal_volume
50pub_type
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journal_title:Transplantation proceedings
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pub_type: 杂志文章,随机对照试验
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.transproceed.2018.12.007
更新日期:2019-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
doi:10.1016/j.transproceed.2007.02.007
更新日期:2007-05-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2004-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-10-01 00:00:00
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journal_title:Transplantation proceedings
pub_type: 杂志文章
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