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Influence of HLA-DQ Matching on Allograft Outcomes in Deceased Donor Kidney Transplantation.

Abstract：

BACKGROUND AND OBJECTIVES:HLA matching at the A, B, and DR loci influences the graft survival rate of deceased donor kidney transplants. The effect of HLA-DQB1 matching on transplant outcomes is still controversial. The aim of this study was to investigate the association of HLA-DQB1 matching with allograft outcomes in deceased donor kidney transplant recipients. METHODS:A retrospective analysis of deceased donor kidney transplant recipients between 2008 and 2014 at the Faculty of Medicine Ramathibodi Hospital, Bangkok, Thailand, was performed. Donor-recipient HLA matching at DQB1 locus was analyzed. The association between HLA-DQB1 mismatches and transplant outcomes was investigated using adjusted Cox regression analysis. RESULTS:A total of 383 deceased donor kidney transplants were performed during the study period, of which 297 with complete clinical and laboratory data were analyzed. The median follow-up time of all patients was 41 months (range, 16.4-65.6 months). Of the 297 recipients, 107 (36.03%) received 0 HLA-DQB1 mismatched kidneys and 190 (63.97%) received 1 or 2 HLA-DQB1 mismatched kidneys. Recipients who have received 1 or 2 HLA-DQB1 mismatched kidneys had a higher risk of acute rejection, with the adjusted hazard ratio of 4.35 (95% CI, 1.41-13.42; P = .01). However, HLA-DQB1 mismatching was not associated with chronic rejection and graft survival. CONCLUSION:Donor-recipient HLA-DQB1 mismatching is associated with acute rejection in deceased donor kidney transplants. However HLA-DQB1 mismatching does not have a negative impact on chronic rejection or graft survival.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Khongjaroensakun N,Kitpoka P,Wiwattanathum P,Sakulchairungrueng B,Thammanichanond D

doi

10.1016/j.transproceed.2018.02.187

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

2371-2376

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(18)30450-0

journal_volume

50

pub_type

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